Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats
It has been previously shown that plasma vitamin A concentration was decreased in both diabetic patients and streptozotocin diabetic rats. In the present study the effect of insulin administration to streptozotocin diabetic rats on plasma and liver vitamin A levels was determined. The daily insulin...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 1991, Vol.11(1), pp.47-52 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | LEICHTER, Joseph MCNEILL, John H. BASU, Tapan K. DUNN, Bruce P. |
| description | It has been previously shown that plasma vitamin A concentration was decreased in both diabetic patients and streptozotocin diabetic rats. In the present study the effect of insulin administration to streptozotocin diabetic rats on plasma and liver vitamin A levels was determined. The daily insulin treatment began 3 weeks after the animals had been made diabetic and continued for 3 weeks. Plasma vitamin A levels were significantly lower in the diabetic rats than in the nondiabetic controls. In the insulin-treated diabetic rats, the plasma vitamin A together with the plasma glucose reverted to the control levels. Livers from the insulin-treated diabetic animals stored vitamin A in about the same amounts as did the livers of the untreated group but significantly more than those of the nondiabetic controls. The liver stores of vitamin A seem to reflect the amount of vitamin A consumed. These results demonstrate that treatment of diabetic rats with insulin restores plasma vitamin A to normal levels. However, the mechanism by which it does so remains to be determined. |
| doi_str_mv | 10.3164/jcbn.11.47 |
| format | Article |
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In the present study the effect of insulin administration to streptozotocin diabetic rats on plasma and liver vitamin A levels was determined. The daily insulin treatment began 3 weeks after the animals had been made diabetic and continued for 3 weeks. Plasma vitamin A levels were significantly lower in the diabetic rats than in the nondiabetic controls. In the insulin-treated diabetic rats, the plasma vitamin A together with the plasma glucose reverted to the control levels. Livers from the insulin-treated diabetic animals stored vitamin A in about the same amounts as did the livers of the untreated group but significantly more than those of the nondiabetic controls. The liver stores of vitamin A seem to reflect the amount of vitamin A consumed. These results demonstrate that treatment of diabetic rats with insulin restores plasma vitamin A to normal levels. However, the mechanism by which it does so remains to be determined.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.11.47</identifier><language>eng</language><publisher>Gifu: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>diabetes ; insulin ; vitamin A</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 1991, Vol.11(1), pp.47-52</ispartof><rights>The Editorial Secretariat of JCBN</rights><rights>Copyright Japan Science and Technology Agency 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>LEICHTER, Joseph</creatorcontrib><creatorcontrib>MCNEILL, John H.</creatorcontrib><creatorcontrib>BASU, Tapan K.</creatorcontrib><creatorcontrib>DUNN, Bruce P.</creatorcontrib><title>Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>It has been previously shown that plasma vitamin A concentration was decreased in both diabetic patients and streptozotocin diabetic rats. In the present study the effect of insulin administration to streptozotocin diabetic rats on plasma and liver vitamin A levels was determined. The daily insulin treatment began 3 weeks after the animals had been made diabetic and continued for 3 weeks. Plasma vitamin A levels were significantly lower in the diabetic rats than in the nondiabetic controls. In the insulin-treated diabetic rats, the plasma vitamin A together with the plasma glucose reverted to the control levels. Livers from the insulin-treated diabetic animals stored vitamin A in about the same amounts as did the livers of the untreated group but significantly more than those of the nondiabetic controls. The liver stores of vitamin A seem to reflect the amount of vitamin A consumed. These results demonstrate that treatment of diabetic rats with insulin restores plasma vitamin A to normal levels. However, the mechanism by which it does so remains to be determined.</description><subject>diabetes</subject><subject>insulin</subject><subject>vitamin A</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNo90F9LwzAQAPAgCs7pi58g4JvQmTTXJH0c89-koIj6GtI00ZYunUk78NvbWdnL3cH9uOMOoUtKFoxyuGlM6ReULkAcoRmVkiQZkfwYzUhO04QQkp-isxgbQoBnHGboae1dO1hvLO4cXvs4tLXHnccvrY4bjbWvcFHvbMAfda83Y2-JC7uzbcRjfVvr0va1wa-6j-foxOk22ov_PEfv93dvq8ekeH5Yr5ZFYgCyPuFgOc1JmprMgiACuKxEBdzlQDTINOUgq0qSqpTCUse4EGVWMpczngJzjM3R1TR3G7rvwcZeNd0Q_LhSUQAqBed5NqrrSZnQxRisU9tQb3T4UZSo_a_U_leKUgVixKsJN7HXn_ZAdRiPa-0fpbnke06nAOLQNV86KOvZL-HAcdo</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>LEICHTER, Joseph</creator><creator>MCNEILL, John H.</creator><creator>BASU, Tapan K.</creator><creator>DUNN, Bruce P.</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>1991</creationdate><title>Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats</title><author>LEICHTER, Joseph ; MCNEILL, John H. ; BASU, Tapan K. ; DUNN, Bruce P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-64e619022c5e4707468d7d46f940a4822648dd80db87e1f3677b5b3f936243f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>diabetes</topic><topic>insulin</topic><topic>vitamin A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEICHTER, Joseph</creatorcontrib><creatorcontrib>MCNEILL, John H.</creatorcontrib><creatorcontrib>BASU, Tapan K.</creatorcontrib><creatorcontrib>DUNN, Bruce P.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEICHTER, Joseph</au><au>MCNEILL, John H.</au><au>BASU, Tapan K.</au><au>DUNN, Bruce P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>1991</date><risdate>1991</risdate><volume>11</volume><issue>1</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>It has been previously shown that plasma vitamin A concentration was decreased in both diabetic patients and streptozotocin diabetic rats. In the present study the effect of insulin administration to streptozotocin diabetic rats on plasma and liver vitamin A levels was determined. The daily insulin treatment began 3 weeks after the animals had been made diabetic and continued for 3 weeks. Plasma vitamin A levels were significantly lower in the diabetic rats than in the nondiabetic controls. In the insulin-treated diabetic rats, the plasma vitamin A together with the plasma glucose reverted to the control levels. Livers from the insulin-treated diabetic animals stored vitamin A in about the same amounts as did the livers of the untreated group but significantly more than those of the nondiabetic controls. The liver stores of vitamin A seem to reflect the amount of vitamin A consumed. These results demonstrate that treatment of diabetic rats with insulin restores plasma vitamin A to normal levels. However, the mechanism by which it does so remains to be determined.</abstract><cop>Gifu</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><doi>10.3164/jcbn.11.47</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | diabetes insulin vitamin A |
| title | Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats |
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