Toxic effects of Triclosan on the detoxification system and breeding of Daphnia magna
The toxic effects of different concentrations of Triclosan (TCS) (1–128 μg/L) on Daphnia magna ( D . magna ) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of D . magna exposed to TCS were investigated by measu...
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| Veröffentlicht in: | Ecotoxicology (London) 2013-11, Vol.22 (9), p.1384-1394 |
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| creator | Peng, Ying Luo, Ying Nie, Xiang-Ping Liao, Wei Yang, Yu-Feng Ying, Guang-Guo |
| description | The toxic effects of different concentrations of Triclosan (TCS) (1–128 μg/L) on
Daphnia magna
(
D
.
magna
) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of
D
.
magna
exposed to TCS were investigated by measuring a series of biomarkers including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), 7-ethoxyresorufin O-deethylase (EROD), Erythromycin
N
-demethylase (ERND) and Aminopyrine N-demethylase (APND). The 48 h LC
50
of TCS was 330 μg/L for
D. magna
. In the chronic test, total number of neonates per female, body length and the intrinsic rate of natural increase (
r
) of
D. magna
increased at the low exposure concentrations (1–16 μg/L) and decreased at the high concentrations (64–128 μg/L), while the total number of molting per adult decreased continually. The GST and CAT activities showed no significant increase in all treatments, and SOD activities were induced after 24-h exposure and inhibited after 48-h exposure at 4–128 μg/L of concentrations. The MDA content increased after 6-h exposure but decreased after 48-h exposure at 4–128 μg/L. EROD activities initially increased after 6-h exposure, but decreased after 24 and 48-h exposure, ERND and APND activities showed a similar temporal pattern among different treatments groups. SOD, MDA and APND were sensitive to TCS, thus they are suitable as potential biomarkers for the exposure to TCS. |
| doi_str_mv | 10.1007/s10646-013-1124-3 |
| format | Article |
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Daphnia magna
(
D
.
magna
) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of
D
.
magna
exposed to TCS were investigated by measuring a series of biomarkers including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), 7-ethoxyresorufin O-deethylase (EROD), Erythromycin
N
-demethylase (ERND) and Aminopyrine N-demethylase (APND). The 48 h LC
50
of TCS was 330 μg/L for
D. magna
. In the chronic test, total number of neonates per female, body length and the intrinsic rate of natural increase (
r
) of
D. magna
increased at the low exposure concentrations (1–16 μg/L) and decreased at the high concentrations (64–128 μg/L), while the total number of molting per adult decreased continually. The GST and CAT activities showed no significant increase in all treatments, and SOD activities were induced after 24-h exposure and inhibited after 48-h exposure at 4–128 μg/L of concentrations. The MDA content increased after 6-h exposure but decreased after 48-h exposure at 4–128 μg/L. EROD activities initially increased after 6-h exposure, but decreased after 24 and 48-h exposure, ERND and APND activities showed a similar temporal pattern among different treatments groups. SOD, MDA and APND were sensitive to TCS, thus they are suitable as potential biomarkers for the exposure to TCS.</description><identifier>ISSN: 0963-9292</identifier><identifier>EISSN: 1573-3017</identifier><identifier>DOI: 10.1007/s10646-013-1124-3</identifier><identifier>PMID: 24022518</identifier><identifier>CODEN: ECOTEL</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Antioxidants - metabolism ; Daphnia - drug effects ; Daphnia - enzymology ; Detoxification ; Earth and Environmental Science ; Ecology ; Ecotoxicology ; Environment ; Environmental Management ; Ethylenediaminetetraacetic acid ; Exposure ; Female ; Glutathione transferase ; Metabolic Detoxication, Phase I ; Neonates ; Reproduction - drug effects ; Superoxide ; Toxicity Tests, Acute ; Toxicity Tests, Chronic ; Triclosan - toxicity ; Water Pollutants, Chemical - toxicity</subject><ispartof>Ecotoxicology (London), 2013-11, Vol.22 (9), p.1384-1394</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-21d4663c02c26179ebea550110f90ed7c37668a3683c856332f960cc3571f1763</citedby><cites>FETCH-LOGICAL-c411t-21d4663c02c26179ebea550110f90ed7c37668a3683c856332f960cc3571f1763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10646-013-1124-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10646-013-1124-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24022518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Ying</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><creatorcontrib>Nie, Xiang-Ping</creatorcontrib><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Yang, Yu-Feng</creatorcontrib><creatorcontrib>Ying, Guang-Guo</creatorcontrib><title>Toxic effects of Triclosan on the detoxification system and breeding of Daphnia magna</title><title>Ecotoxicology (London)</title><addtitle>Ecotoxicology</addtitle><addtitle>Ecotoxicology</addtitle><description>The toxic effects of different concentrations of Triclosan (TCS) (1–128 μg/L) on
Daphnia magna
(
D
.
magna
) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of
D
.
magna
exposed to TCS were investigated by measuring a series of biomarkers including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), 7-ethoxyresorufin O-deethylase (EROD), Erythromycin
N
-demethylase (ERND) and Aminopyrine N-demethylase (APND). The 48 h LC
50
of TCS was 330 μg/L for
D. magna
. In the chronic test, total number of neonates per female, body length and the intrinsic rate of natural increase (
r
) of
D. magna
increased at the low exposure concentrations (1–16 μg/L) and decreased at the high concentrations (64–128 μg/L), while the total number of molting per adult decreased continually. The GST and CAT activities showed no significant increase in all treatments, and SOD activities were induced after 24-h exposure and inhibited after 48-h exposure at 4–128 μg/L of concentrations. The MDA content increased after 6-h exposure but decreased after 48-h exposure at 4–128 μg/L. EROD activities initially increased after 6-h exposure, but decreased after 24 and 48-h exposure, ERND and APND activities showed a similar temporal pattern among different treatments groups. SOD, MDA and APND were sensitive to TCS, thus they are suitable as potential biomarkers for the exposure to TCS.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Daphnia - drug effects</subject><subject>Daphnia - enzymology</subject><subject>Detoxification</subject><subject>Earth and Environmental Science</subject><subject>Ecology</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Management</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Exposure</subject><subject>Female</subject><subject>Glutathione transferase</subject><subject>Metabolic Detoxication, Phase I</subject><subject>Neonates</subject><subject>Reproduction - drug effects</subject><subject>Superoxide</subject><subject>Toxicity Tests, Acute</subject><subject>Toxicity Tests, Chronic</subject><subject>Triclosan - toxicity</subject><subject>Water Pollutants, Chemical - 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effects of Triclosan on the detoxification system and breeding of Daphnia magna</title><author>Peng, Ying ; Luo, Ying ; Nie, Xiang-Ping ; Liao, Wei ; Yang, Yu-Feng ; Ying, Guang-Guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-21d4663c02c26179ebea550110f90ed7c37668a3683c856332f960cc3571f1763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Daphnia - drug effects</topic><topic>Daphnia - enzymology</topic><topic>Detoxification</topic><topic>Earth and Environmental Science</topic><topic>Ecology</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Management</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Exposure</topic><topic>Female</topic><topic>Glutathione transferase</topic><topic>Metabolic Detoxication, Phase I</topic><topic>Neonates</topic><topic>Reproduction 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Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><jtitle>Ecotoxicology (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Ying</au><au>Luo, Ying</au><au>Nie, Xiang-Ping</au><au>Liao, Wei</au><au>Yang, Yu-Feng</au><au>Ying, Guang-Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic effects of Triclosan on the detoxification system and breeding of Daphnia magna</atitle><jtitle>Ecotoxicology (London)</jtitle><stitle>Ecotoxicology</stitle><addtitle>Ecotoxicology</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>22</volume><issue>9</issue><spage>1384</spage><epage>1394</epage><pages>1384-1394</pages><issn>0963-9292</issn><eissn>1573-3017</eissn><coden>ECOTEL</coden><abstract>The toxic effects of different concentrations of Triclosan (TCS) (1–128 μg/L) on
Daphnia magna
(
D
.
magna
) were investigated by acute (48 h) and chronic (21-day) toxicity tests. The response of antioxidase system and Phase I metabolism process of
D
.
magna
exposed to TCS were investigated by measuring a series of biomarkers including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), 7-ethoxyresorufin O-deethylase (EROD), Erythromycin
N
-demethylase (ERND) and Aminopyrine N-demethylase (APND). The 48 h LC
50
of TCS was 330 μg/L for
D. magna
. In the chronic test, total number of neonates per female, body length and the intrinsic rate of natural increase (
r
) of
D. magna
increased at the low exposure concentrations (1–16 μg/L) and decreased at the high concentrations (64–128 μg/L), while the total number of molting per adult decreased continually. The GST and CAT activities showed no significant increase in all treatments, and SOD activities were induced after 24-h exposure and inhibited after 48-h exposure at 4–128 μg/L of concentrations. The MDA content increased after 6-h exposure but decreased after 48-h exposure at 4–128 μg/L. EROD activities initially increased after 6-h exposure, but decreased after 24 and 48-h exposure, ERND and APND activities showed a similar temporal pattern among different treatments groups. SOD, MDA and APND were sensitive to TCS, thus they are suitable as potential biomarkers for the exposure to TCS.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24022518</pmid><doi>10.1007/s10646-013-1124-3</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0963-9292 |
| ispartof | Ecotoxicology (London), 2013-11, Vol.22 (9), p.1384-1394 |
| issn | 0963-9292 1573-3017 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antioxidants - metabolism Daphnia - drug effects Daphnia - enzymology Detoxification Earth and Environmental Science Ecology Ecotoxicology Environment Environmental Management Ethylenediaminetetraacetic acid Exposure Female Glutathione transferase Metabolic Detoxication, Phase I Neonates Reproduction - drug effects Superoxide Toxicity Tests, Acute Toxicity Tests, Chronic Triclosan - toxicity Water Pollutants, Chemical - toxicity |
| title | Toxic effects of Triclosan on the detoxification system and breeding of Daphnia magna |
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