The lack of association between components of metabolic syndrome and treatment resistance in depression
Rationale Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear. Objectives The aim of the study was to investigate the relationship between TR...
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| Veröffentlicht in: | Psychopharmacology 2013-11, Vol.230 (1), p.15-21 |
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| creator | Sagud, Marina Mihaljevic-Peles, Alma Uzun, Suzana Cusa, Bjanka Vuksan Kozumplik, Oliver Kudlek-Mikulic, Suzan Mustapic, Maja Barisic, Ivan Muck-Seler, Dorotea Pivac, Nela |
| description | Rationale
Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear.
Objectives
The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS.
Methods
This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale.
Results
TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients.
Conclusions
The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants. |
| doi_str_mv | 10.1007/s00213-013-3085-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1441395750</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A347656624</galeid><sourcerecordid>A347656624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-c8c3383b3efcd778fc70866c1713e74b1cbe011809b7bd74e339165333a59c2d3</originalsourceid><addsrcrecordid>eNp1kVuPFCEQhYnRuOPqD_DFkPjcK1B0Qz9uNt6STXxZnwldXT2yTsMITNz99zKZ9ZYohJBUfedwOYy9lOJCCmHeFCGUhE60BcL23d0jtpEaVKeEUY_ZRghoHdnbM_aslFvRhrb6KTtT0JtRq3HDtjdfiO88fuVp4b6UhMHXkCKfqH4nihzTuk-RYi1HYqXqp7QLyMt9nHNaifs485rJ17VBPFMJpfqIxEPkM-1boTS_5-zJ4neFXjzs5-zzu7c3Vx-660_vP15dXneoraodWgSwMAEtOBtjFzTCDgNKI4GMniROJKS0YpzMNBtNAKMcegDw_YhqhnP2-uS7z-nbgUp1t-mQYzvSSa0ljL3pxW9q63fkQlxSzR7XUNBdgjZDPwxKN-riH1SbM60B26csodX_EsiTAHMqJdPi9jmsPt87KdwxMXdKzLXE3DExd9c0rx4ufJhWmn8pfkbUAHUCSmvFLeU_XvRf1x9XaqCz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1441395750</pqid></control><display><type>article</type><title>The lack of association between components of metabolic syndrome and treatment resistance in depression</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Sagud, Marina ; Mihaljevic-Peles, Alma ; Uzun, Suzana ; Cusa, Bjanka Vuksan ; Kozumplik, Oliver ; Kudlek-Mikulic, Suzan ; Mustapic, Maja ; Barisic, Ivan ; Muck-Seler, Dorotea ; Pivac, Nela</creator><creatorcontrib>Sagud, Marina ; Mihaljevic-Peles, Alma ; Uzun, Suzana ; Cusa, Bjanka Vuksan ; Kozumplik, Oliver ; Kudlek-Mikulic, Suzan ; Mustapic, Maja ; Barisic, Ivan ; Muck-Seler, Dorotea ; Pivac, Nela</creatorcontrib><description>Rationale
Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear.
Objectives
The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS.
Methods
This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale.
Results
TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients.
Conclusions
The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-013-3085-x</identifier><identifier>PMID: 23579429</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Antidepressants ; Antidepressive Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Complications and side effects ; Cross-Sectional Studies ; Depression, Mental ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - epidemiology ; Dosage and administration ; Drug Resistance ; Drug therapy ; Female ; Humans ; Male ; Mental depression ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Metabolic syndrome X ; Middle Aged ; Neurosciences ; Original Investigation ; Patient outcomes ; Pharmacology/Toxicology ; Prevalence ; Psychiatric Status Rating Scales ; Psychiatry ; Psychopharmacology ; Risk Factors ; Severity of Illness Index ; Suicide, Attempted - statistics & numerical data ; Time Factors</subject><ispartof>Psychopharmacology, 2013-11, Vol.230 (1), p.15-21</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-c8c3383b3efcd778fc70866c1713e74b1cbe011809b7bd74e339165333a59c2d3</citedby><cites>FETCH-LOGICAL-c482t-c8c3383b3efcd778fc70866c1713e74b1cbe011809b7bd74e339165333a59c2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-013-3085-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-013-3085-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23579429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sagud, Marina</creatorcontrib><creatorcontrib>Mihaljevic-Peles, Alma</creatorcontrib><creatorcontrib>Uzun, Suzana</creatorcontrib><creatorcontrib>Cusa, Bjanka Vuksan</creatorcontrib><creatorcontrib>Kozumplik, Oliver</creatorcontrib><creatorcontrib>Kudlek-Mikulic, Suzan</creatorcontrib><creatorcontrib>Mustapic, Maja</creatorcontrib><creatorcontrib>Barisic, Ivan</creatorcontrib><creatorcontrib>Muck-Seler, Dorotea</creatorcontrib><creatorcontrib>Pivac, Nela</creatorcontrib><title>The lack of association between components of metabolic syndrome and treatment resistance in depression</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear.
Objectives
The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS.
Methods
This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale.
Results
TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients.
Conclusions
The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants.</description><subject>Adult</subject><subject>Aged</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Depression, Mental</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Dosage and administration</subject><subject>Drug Resistance</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mental depression</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic syndrome X</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Patient outcomes</subject><subject>Pharmacology/Toxicology</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Suicide, Attempted - statistics & numerical data</subject><subject>Time Factors</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVuPFCEQhYnRuOPqD_DFkPjcK1B0Qz9uNt6STXxZnwldXT2yTsMITNz99zKZ9ZYohJBUfedwOYy9lOJCCmHeFCGUhE60BcL23d0jtpEaVKeEUY_ZRghoHdnbM_aslFvRhrb6KTtT0JtRq3HDtjdfiO88fuVp4b6UhMHXkCKfqH4nihzTuk-RYi1HYqXqp7QLyMt9nHNaifs485rJ17VBPFMJpfqIxEPkM-1boTS_5-zJ4neFXjzs5-zzu7c3Vx-660_vP15dXneoraodWgSwMAEtOBtjFzTCDgNKI4GMniROJKS0YpzMNBtNAKMcegDw_YhqhnP2-uS7z-nbgUp1t-mQYzvSSa0ljL3pxW9q63fkQlxSzR7XUNBdgjZDPwxKN-riH1SbM60B26csodX_EsiTAHMqJdPi9jmsPt87KdwxMXdKzLXE3DExd9c0rx4ufJhWmn8pfkbUAHUCSmvFLeU_XvRf1x9XaqCz</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Sagud, Marina</creator><creator>Mihaljevic-Peles, Alma</creator><creator>Uzun, Suzana</creator><creator>Cusa, Bjanka Vuksan</creator><creator>Kozumplik, Oliver</creator><creator>Kudlek-Mikulic, Suzan</creator><creator>Mustapic, Maja</creator><creator>Barisic, Ivan</creator><creator>Muck-Seler, Dorotea</creator><creator>Pivac, Nela</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20131101</creationdate><title>The lack of association between components of metabolic syndrome and treatment resistance in depression</title><author>Sagud, Marina ; Mihaljevic-Peles, Alma ; Uzun, Suzana ; Cusa, Bjanka Vuksan ; Kozumplik, Oliver ; Kudlek-Mikulic, Suzan ; Mustapic, Maja ; Barisic, Ivan ; Muck-Seler, Dorotea ; Pivac, Nela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-c8c3383b3efcd778fc70866c1713e74b1cbe011809b7bd74e339165333a59c2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>Depression, Mental</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Dosage and administration</topic><topic>Drug Resistance</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mental depression</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic syndrome X</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Patient outcomes</topic><topic>Pharmacology/Toxicology</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Suicide, Attempted - statistics & numerical data</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sagud, Marina</creatorcontrib><creatorcontrib>Mihaljevic-Peles, Alma</creatorcontrib><creatorcontrib>Uzun, Suzana</creatorcontrib><creatorcontrib>Cusa, Bjanka Vuksan</creatorcontrib><creatorcontrib>Kozumplik, Oliver</creatorcontrib><creatorcontrib>Kudlek-Mikulic, Suzan</creatorcontrib><creatorcontrib>Mustapic, Maja</creatorcontrib><creatorcontrib>Barisic, Ivan</creatorcontrib><creatorcontrib>Muck-Seler, Dorotea</creatorcontrib><creatorcontrib>Pivac, Nela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagud, Marina</au><au>Mihaljevic-Peles, Alma</au><au>Uzun, Suzana</au><au>Cusa, Bjanka Vuksan</au><au>Kozumplik, Oliver</au><au>Kudlek-Mikulic, Suzan</au><au>Mustapic, Maja</au><au>Barisic, Ivan</au><au>Muck-Seler, Dorotea</au><au>Pivac, Nela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The lack of association between components of metabolic syndrome and treatment resistance in depression</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>230</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear.
Objectives
The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS.
Methods
This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale.
Results
TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients.
Conclusions
The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23579429</pmid><doi>10.1007/s00213-013-3085-x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychopharmacology, 2013-11, Vol.230 (1), p.15-21 |
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| subjects | Adult Aged Antidepressants Antidepressive Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Complications and side effects Cross-Sectional Studies Depression, Mental Depressive Disorder, Major - drug therapy Depressive Disorder, Major - epidemiology Dosage and administration Drug Resistance Drug therapy Female Humans Male Mental depression Metabolic syndrome Metabolic Syndrome - epidemiology Metabolic syndrome X Middle Aged Neurosciences Original Investigation Patient outcomes Pharmacology/Toxicology Prevalence Psychiatric Status Rating Scales Psychiatry Psychopharmacology Risk Factors Severity of Illness Index Suicide, Attempted - statistics & numerical data Time Factors |
| title | The lack of association between components of metabolic syndrome and treatment resistance in depression |
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