XPLN is an endogenous inhibitor of mTORC2

Mammalian target of rapamycin complex 2 (mTORC2) controls a wide range of cellular and developmental processes, but its regulation remains incompletely understood. Through a yeast two-hybrid screen, we have identified XPLN (e x change factor found in p latelets, l eukemic, and n euronal tissues), a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-10, Vol.110 (40), p.15979-15984
Hauptverfasser:	Khanna, Nidhi, Fang, Yimin, Yoon, Mee-Sup, Chen, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Apoptosis B lymphocytes Biological Sciences Birds of prey Blotting, Western Carrier Proteins - metabolism cell viability Cellular differentiation Delta cells guanosinetriphosphatase HEK293 Cells HeLa Cells Humans Immunoprecipitation Kinases Lentivirus Mammals Mechanistic Target of Rapamycin Complex 2 Mice Multiprotein Complexes - antagonists & inhibitors Myoblasts Phosphorylation Physiological regulation Plasmids - genetics Proteins Proto-Oncogene Proteins c-akt - metabolism Rapamycin-Insensitive Companion of mTOR Protein regulatory proteins Rho Guanine Nucleotide Exchange Factors - genetics Rho Guanine Nucleotide Exchange Factors - metabolism RNA Interference Signal Transduction - genetics Signal Transduction - physiology Tissues TOR Serine-Threonine Kinases - antagonists & inhibitors Two-Hybrid System Techniques
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