Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

Aging is one of the most fundamental, yet least understood biological processes that affect all forms of eukaryotic life. Mitochondria are intimately involved in aging, but the underlying molecular mechanisms are largely unknown. Electron cryotomography of whole mitochondria from the aging model org...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-09, Vol.110 (38), p.15301-15306
Hauptverfasser:	Daum, Bertram, Walter, Andreas, Horst, Angelika, Osiewacz, Heinz D., Kühlbrandt, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase adenosine triphosphate Aging Aging - physiology Apoptosis Bacteria Biological Sciences Cells Curvature cyclophilins Cyclophilins - metabolism Cytoplasm Dimerization Dimers dissociation Electron Microscope Tomography H+/K+-exchanging ATPase H-transporting ATP synthase Membranes Microscopy, Electron, Transmission Mitochondria Mitochondria - physiology Mitochondria - ultrastructure Mitochondrial membranes Mitochondrial Membranes - metabolism Mitochondrial Membranes - ultrastructure Mitochondrial Proton-Translocating ATPases - chemistry Mitochondrial Proton-Translocating ATPases - metabolism Models, Molecular Monomers P branes Peptidyl-Prolyl Isomerase F Podospora Podospora - enzymology Podospora - physiology Podospora anserina String theory Yeasts
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