The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats
Apoptosis, known as programmed cell death, plays a crucial role in normal development and tissue homeostasis. Apoptosis is also involved in neurodegenerative diseases such as Alzheimer’s disease. Amnesia refers to the loss of memory and can also be a warning sign of neurodegenerative diseases. The a...
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| Veröffentlicht in: | Anatomical science international 2013-09, Vol.88 (4), p.217-222 |
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| creator | Jahanshahi, M. Nickmahzar, E. G. Babakordi, F. |
| description | Apoptosis, known as programmed cell death, plays a crucial role in normal development and tissue homeostasis. Apoptosis is also involved in neurodegenerative diseases such as Alzheimer’s disease. Amnesia refers to the loss of memory and can also be a warning sign of neurodegenerative diseases. The antioxidant properties of
Ginkgo biloba
extract was known previously. Therefore, the aim of this study was to examine the effects of
Ginkgo biloba
extract on the rat’s hippocampal apoptotic neurons number after Scopolamine based amnesia. Thirty-six adult male Wistar rats were used. Rats were randomly divided into control, sham, protective and treatment groups. The rats in the sham group received only scopolamine hydrobromide (3 mg/kg) intraperitoneally. The rats in the protective and treatment groups received
Ginkgo biloba
extract (40, 80 mg/kg) for 7 days intraperitoneally before/after scopolamine injection. Then 48 h after the last injection, the brains of rats were withdrawn and fixed with paraformaldehyde, and then, after histological processing, the slices were stained with the TUNEL kit for apoptotic neurons. Data were compared by the ANOVA Post Hoc Tukey test;
P
|
| doi_str_mv | 10.1007/s12565-013-0188-8 |
| format | Article |
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Ginkgo biloba
extract was known previously. Therefore, the aim of this study was to examine the effects of
Ginkgo biloba
extract on the rat’s hippocampal apoptotic neurons number after Scopolamine based amnesia. Thirty-six adult male Wistar rats were used. Rats were randomly divided into control, sham, protective and treatment groups. The rats in the sham group received only scopolamine hydrobromide (3 mg/kg) intraperitoneally. The rats in the protective and treatment groups received
Ginkgo biloba
extract (40, 80 mg/kg) for 7 days intraperitoneally before/after scopolamine injection. Then 48 h after the last injection, the brains of rats were withdrawn and fixed with paraformaldehyde, and then, after histological processing, the slices were stained with the TUNEL kit for apoptotic neurons. Data were compared by the ANOVA Post Hoc Tukey test;
P
< 0.05 was considered significant. Our results showed that Scopolamine (in the sham group) increased significantly the number of apoptotic neurons in all areas of the hippocampus compared with the control. Whereas,
Ginkgo biloba
extract reduce the neuronal apoptosis in the hippocampus before and/or after encounter with scopolamine. We concluded that pretreatment and treatment injection of
Ginkgo biloba
extract can have a protective effect for neurons and it can limit apoptosis in all area of the hippocampus.</description><identifier>ISSN: 1447-6959</identifier><identifier>EISSN: 1447-073X</identifier><identifier>DOI: 10.1007/s12565-013-0188-8</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Anatomy ; Animal Anatomy ; Animal Physiology ; Antioxidants ; Apoptosis ; Cell Biology ; Histology ; Homeostasis ; Human Physiology ; Medicine ; Medicine & Public Health ; Morphology ; Neurodegeneration ; Neurosciences ; Original Article ; Rodents ; Trees</subject><ispartof>Anatomical science international, 2013-09, Vol.88 (4), p.217-222</ispartof><rights>Japanese Association of Anatomists 2013</rights><rights>Copyright Springer Publishing Company Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-ae7d60804a5e12b033ade24ae028e64d506a6a91c9c72229f75bb551ba81c54c3</citedby><cites>FETCH-LOGICAL-c369t-ae7d60804a5e12b033ade24ae028e64d506a6a91c9c72229f75bb551ba81c54c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12565-013-0188-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12565-013-0188-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Jahanshahi, M.</creatorcontrib><creatorcontrib>Nickmahzar, E. G.</creatorcontrib><creatorcontrib>Babakordi, F.</creatorcontrib><title>The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats</title><title>Anatomical science international</title><addtitle>Anat Sci Int</addtitle><description>Apoptosis, known as programmed cell death, plays a crucial role in normal development and tissue homeostasis. Apoptosis is also involved in neurodegenerative diseases such as Alzheimer’s disease. Amnesia refers to the loss of memory and can also be a warning sign of neurodegenerative diseases. The antioxidant properties of
Ginkgo biloba
extract was known previously. Therefore, the aim of this study was to examine the effects of
Ginkgo biloba
extract on the rat’s hippocampal apoptotic neurons number after Scopolamine based amnesia. Thirty-six adult male Wistar rats were used. Rats were randomly divided into control, sham, protective and treatment groups. The rats in the sham group received only scopolamine hydrobromide (3 mg/kg) intraperitoneally. The rats in the protective and treatment groups received
Ginkgo biloba
extract (40, 80 mg/kg) for 7 days intraperitoneally before/after scopolamine injection. Then 48 h after the last injection, the brains of rats were withdrawn and fixed with paraformaldehyde, and then, after histological processing, the slices were stained with the TUNEL kit for apoptotic neurons. Data were compared by the ANOVA Post Hoc Tukey test;
P
< 0.05 was considered significant. Our results showed that Scopolamine (in the sham group) increased significantly the number of apoptotic neurons in all areas of the hippocampus compared with the control. Whereas,
Ginkgo biloba
extract reduce the neuronal apoptosis in the hippocampus before and/or after encounter with scopolamine. We concluded that pretreatment and treatment injection of
Ginkgo biloba
extract can have a protective effect for neurons and it can limit apoptosis in all area of the hippocampus.</description><subject>Anatomy</subject><subject>Animal Anatomy</subject><subject>Animal Physiology</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Cell Biology</subject><subject>Histology</subject><subject>Homeostasis</subject><subject>Human Physiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>Neurodegeneration</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Rodents</subject><subject>Trees</subject><issn>1447-6959</issn><issn>1447-073X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kM9LwzAUx4MoOKd_gLeA52p-NGl7lKFTGHiZ4C28pq9b5tbEpAX97-3oDl48PPIg3-_nwYeQW87uOWPFQ-JCaZUxLscpy6w8IzOe50XGCvlxftp1papLcpXSjjFeKS5nxKy3SLFt0fbUt3Tpus-Np7Xb-xoofvcRjh8dTdYHv4eD6zBzXTNYbCgEH3qfXKKuo_3I2boQvIVDGNIRFqFP1-SihX3Cm9M7J-_PT-vFS7Z6W74uHleZlbrqM8Ci0axkOSjkomZSQoMiB2SiRJ03imnQUHFb2UIIUbWFqmuleA0ltyq3ck7uJm6I_mvA1JudH2I3njQ8l1qognE1pviUstGnFLE1IboDxB_DmTl6NJNHM3o0R4-mHDti6qQx220w_iH_W_oFBX91_g</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Jahanshahi, M.</creator><creator>Nickmahzar, E. G.</creator><creator>Babakordi, F.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20130901</creationdate><title>The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats</title><author>Jahanshahi, M. ; Nickmahzar, E. G. ; Babakordi, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-ae7d60804a5e12b033ade24ae028e64d506a6a91c9c72229f75bb551ba81c54c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anatomy</topic><topic>Animal Anatomy</topic><topic>Animal Physiology</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Cell Biology</topic><topic>Histology</topic><topic>Homeostasis</topic><topic>Human Physiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>Neurodegeneration</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Rodents</topic><topic>Trees</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jahanshahi, M.</creatorcontrib><creatorcontrib>Nickmahzar, E. G.</creatorcontrib><creatorcontrib>Babakordi, F.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Anatomical science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jahanshahi, M.</au><au>Nickmahzar, E. G.</au><au>Babakordi, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats</atitle><jtitle>Anatomical science international</jtitle><stitle>Anat Sci Int</stitle><date>2013-09-01</date><risdate>2013</risdate><volume>88</volume><issue>4</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>1447-6959</issn><eissn>1447-073X</eissn><abstract>Apoptosis, known as programmed cell death, plays a crucial role in normal development and tissue homeostasis. Apoptosis is also involved in neurodegenerative diseases such as Alzheimer’s disease. Amnesia refers to the loss of memory and can also be a warning sign of neurodegenerative diseases. The antioxidant properties of
Ginkgo biloba
extract was known previously. Therefore, the aim of this study was to examine the effects of
Ginkgo biloba
extract on the rat’s hippocampal apoptotic neurons number after Scopolamine based amnesia. Thirty-six adult male Wistar rats were used. Rats were randomly divided into control, sham, protective and treatment groups. The rats in the sham group received only scopolamine hydrobromide (3 mg/kg) intraperitoneally. The rats in the protective and treatment groups received
Ginkgo biloba
extract (40, 80 mg/kg) for 7 days intraperitoneally before/after scopolamine injection. Then 48 h after the last injection, the brains of rats were withdrawn and fixed with paraformaldehyde, and then, after histological processing, the slices were stained with the TUNEL kit for apoptotic neurons. Data were compared by the ANOVA Post Hoc Tukey test;
P
< 0.05 was considered significant. Our results showed that Scopolamine (in the sham group) increased significantly the number of apoptotic neurons in all areas of the hippocampus compared with the control. Whereas,
Ginkgo biloba
extract reduce the neuronal apoptosis in the hippocampus before and/or after encounter with scopolamine. We concluded that pretreatment and treatment injection of
Ginkgo biloba
extract can have a protective effect for neurons and it can limit apoptosis in all area of the hippocampus.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><doi>10.1007/s12565-013-0188-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Anatomy Animal Anatomy Animal Physiology Antioxidants Apoptosis Cell Biology Histology Homeostasis Human Physiology Medicine Medicine & Public Health Morphology Neurodegeneration Neurosciences Original Article Rodents Trees |
| title | The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats |
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