Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status

PURPOSE: The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory...

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Veröffentlicht in:	European journal of nutrition 2013-10, Vol.52 (7), p.1787-1799
Hauptverfasser:	Hemshekhar, Mahadevappa, Thushara, Ram Mohan, Jnaneshwari, Sadashivaiah, Devaraja, Sannaningaiah, Kemparaju, Kempaiah, Girish, Kesturu Subbaiah
Format:	Artikel
Sprache:	eng
Schlagworte:	acid phosphatase Alanine Transaminase - blood Animals Anti-Inflammatory Agents - administration & dosage antioxidants Antioxidants - administration & dosage arthritis Arthritis, Experimental - drug therapy Aspartate Aminotransferases - blood Benzodioxoles - administration & dosage blood serum bone resorption cardiovascular diseases cartilage catalase Catalase - metabolism cathepsin D Chemistry Chemistry and Materials Science Cyclooxygenase 2 - metabolism diabetes extracellular matrix Extracellular Matrix - metabolism gelatinase A glutathione transferase Glutathione Transferase - metabolism homeostasis hyaluronoglucosaminidase hydrogen peroxide Hydrogen Peroxide - metabolism inflammation Inflammation Mediators - metabolism interleukin-1beta Interleukin-1beta - metabolism interleukin-6 Interleukin-6 - metabolism Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism neutralization Nutrition Original Contribution oxidative stress Oxidative Stress - drug effects Phenols - administration & dosage Rats Rats, Wistar Reactive Oxygen Species - metabolism sesame seed superoxide dismutase Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism tumor necrosis factors
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