Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status
PURPOSE: The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory...
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| Veröffentlicht in: | European journal of nutrition 2013-10, Vol.52 (7), p.1787-1799 |
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| container_title | European journal of nutrition |
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| creator | Hemshekhar, Mahadevappa Thushara, Ram Mohan Jnaneshwari, Sadashivaiah Devaraja, Sannaningaiah Kemparaju, Kempaiah Girish, Kesturu Subbaiah |
| description | PURPOSE: The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. METHODS: Arthritis was induced using Freund’s complete adjuvant to hind paw of experimental rats. The physical and biochemical alterations and its recovery by sesamol were assessed by measuring enzymatic and non-enzymatic mediators. Arthritis-induced inflammation, oxidative stress and their protective by sesamol were measured by determining the levels of pro-inflammatory cytokines and oxidative stress markers. RESULTS: In the present study, sesamol was demonstrated to alleviate arthritis-induced cartilage degeneration by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases (MMP-13, MMP-3 and MMP-9). It also protected bone resorption by reducing the elevated levels of bone joint exoglycosidases, cathepsin D and tartarate-resistant acid phosphatases. Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL-1β, IL-6, COX-2, PGE₂, ROS, and H₂O₂,) effectively. In addition, sesamol neutralizes arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase. CONCLUSION: Taken together, the study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Thus, sesamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes. |
| doi_str_mv | 10.1007/s00394-012-0482-6 |
| format | Article |
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Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. METHODS: Arthritis was induced using Freund’s complete adjuvant to hind paw of experimental rats. The physical and biochemical alterations and its recovery by sesamol were assessed by measuring enzymatic and non-enzymatic mediators. Arthritis-induced inflammation, oxidative stress and their protective by sesamol were measured by determining the levels of pro-inflammatory cytokines and oxidative stress markers. RESULTS: In the present study, sesamol was demonstrated to alleviate arthritis-induced cartilage degeneration by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases (MMP-13, MMP-3 and MMP-9). It also protected bone resorption by reducing the elevated levels of bone joint exoglycosidases, cathepsin D and tartarate-resistant acid phosphatases. Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL-1β, IL-6, COX-2, PGE₂, ROS, and H₂O₂,) effectively. In addition, sesamol neutralizes arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase. CONCLUSION: Taken together, the study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Thus, sesamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-012-0482-6</identifier><identifier>PMID: 23269651</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>acid phosphatase ; Alanine Transaminase - blood ; Animals ; Anti-Inflammatory Agents - administration & dosage ; antioxidants ; Antioxidants - administration & dosage ; arthritis ; Arthritis, Experimental - drug therapy ; Aspartate Aminotransferases - blood ; Benzodioxoles - administration & dosage ; blood serum ; bone resorption ; cardiovascular diseases ; cartilage ; catalase ; Catalase - metabolism ; cathepsin D ; Chemistry ; Chemistry and Materials Science ; Cyclooxygenase 2 - metabolism ; diabetes ; extracellular matrix ; Extracellular Matrix - metabolism ; gelatinase A ; glutathione transferase ; Glutathione Transferase - metabolism ; homeostasis ; hyaluronoglucosaminidase ; hydrogen peroxide ; Hydrogen Peroxide - metabolism ; inflammation ; Inflammation Mediators - metabolism ; interleukin-1beta ; Interleukin-1beta - metabolism ; interleukin-6 ; Interleukin-6 - metabolism ; Matrix Metalloproteinase 13 - genetics ; Matrix Metalloproteinase 13 - metabolism ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; neutralization ; Nutrition ; Original Contribution ; oxidative stress ; Oxidative Stress - drug effects ; Phenols - administration & dosage ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; sesame seed ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Tumor Necrosis Factor-alpha - metabolism ; tumor necrosis factors</subject><ispartof>European journal of nutrition, 2013-10, Vol.52 (7), p.1787-1799</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c1c0b6f311dc8b73d959e9b25ae5a9d6295c2268681f4ea3f502f3b94f5377003</citedby><cites>FETCH-LOGICAL-c396t-c1c0b6f311dc8b73d959e9b25ae5a9d6295c2268681f4ea3f502f3b94f5377003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-012-0482-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-012-0482-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23269651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hemshekhar, Mahadevappa</creatorcontrib><creatorcontrib>Thushara, Ram Mohan</creatorcontrib><creatorcontrib>Jnaneshwari, Sadashivaiah</creatorcontrib><creatorcontrib>Devaraja, Sannaningaiah</creatorcontrib><creatorcontrib>Kemparaju, Kempaiah</creatorcontrib><creatorcontrib>Girish, Kesturu Subbaiah</creatorcontrib><title>Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>PURPOSE: The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. METHODS: Arthritis was induced using Freund’s complete adjuvant to hind paw of experimental rats. The physical and biochemical alterations and its recovery by sesamol were assessed by measuring enzymatic and non-enzymatic mediators. Arthritis-induced inflammation, oxidative stress and their protective by sesamol were measured by determining the levels of pro-inflammatory cytokines and oxidative stress markers. RESULTS: In the present study, sesamol was demonstrated to alleviate arthritis-induced cartilage degeneration by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases (MMP-13, MMP-3 and MMP-9). It also protected bone resorption by reducing the elevated levels of bone joint exoglycosidases, cathepsin D and tartarate-resistant acid phosphatases. Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL-1β, IL-6, COX-2, PGE₂, ROS, and H₂O₂,) effectively. In addition, sesamol neutralizes arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase. CONCLUSION: Taken together, the study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Thus, sesamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes.</description><subject>acid phosphatase</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>arthritis</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Benzodioxoles - administration & dosage</subject><subject>blood serum</subject><subject>bone resorption</subject><subject>cardiovascular diseases</subject><subject>cartilage</subject><subject>catalase</subject><subject>Catalase - metabolism</subject><subject>cathepsin D</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>diabetes</subject><subject>extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>gelatinase A</subject><subject>glutathione transferase</subject><subject>Glutathione Transferase - metabolism</subject><subject>homeostasis</subject><subject>hyaluronoglucosaminidase</subject><subject>hydrogen peroxide</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>interleukin-1beta</subject><subject>Interleukin-1beta - metabolism</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>Matrix Metalloproteinase 13 - genetics</subject><subject>Matrix Metalloproteinase 13 - metabolism</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>neutralization</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phenols - administration & dosage</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>sesame seed</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>tumor necrosis factors</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9Uctu1DAUtRCIPuAD2IAltg34ETvxsqqAVqrEArq2bmJ78Cixi-1UM_0ePhSP0o5Ysbi6V7rnIZ2D0DtKPlFCus-ZEK7ahlDWkLZnjXyBTmnLZSMZFS-PN-lO0FnOW0II45K-RieMM6mkoKfoz2UpNixQfAw4OgxmuzxAKI0PZhmtwZDKr-SLz3jYY-NtgbTH2WaY44QfPOA5mmU68n1wE8wzlFhhszX-cOULbHclwWinqWITrv_kd9jYTQLjwwbb8LifbcYQqmOoYjtv6sa5QFnyG_TKwZTt26d9ju6-fvl5dd3cfv92c3V524xcydKMdCSDdJxSM_ZDx40SyqqBCbAClJFMiZEx2cueutYCd4IwxwfVOsG7rmZ5jj6uuvcp_l5sLnoblxSqpa5Rip4yRWVF0RU1pphzsk7fJz_XWDQl-tCLXnvRtRd96EUfOO-flJehpnJkPBdRAWwF5PoKG5v-sf6P6oeV5CBq2CSf9d0PRmhL6rSccP4XDDWl7w</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Hemshekhar, Mahadevappa</creator><creator>Thushara, Ram Mohan</creator><creator>Jnaneshwari, Sadashivaiah</creator><creator>Devaraja, Sannaningaiah</creator><creator>Kemparaju, Kempaiah</creator><creator>Girish, Kesturu Subbaiah</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20131001</creationdate><title>Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status</title><author>Hemshekhar, Mahadevappa ; Thushara, Ram Mohan ; Jnaneshwari, Sadashivaiah ; Devaraja, Sannaningaiah ; Kemparaju, Kempaiah ; Girish, Kesturu Subbaiah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c1c0b6f311dc8b73d959e9b25ae5a9d6295c2268681f4ea3f502f3b94f5377003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acid phosphatase</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>arthritis</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Benzodioxoles - administration & dosage</topic><topic>blood serum</topic><topic>bone resorption</topic><topic>cardiovascular diseases</topic><topic>cartilage</topic><topic>catalase</topic><topic>Catalase - metabolism</topic><topic>cathepsin D</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>diabetes</topic><topic>extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>gelatinase A</topic><topic>glutathione transferase</topic><topic>Glutathione Transferase - metabolism</topic><topic>homeostasis</topic><topic>hyaluronoglucosaminidase</topic><topic>hydrogen peroxide</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>interleukin-1beta</topic><topic>Interleukin-1beta - metabolism</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>Matrix Metalloproteinase 13 - genetics</topic><topic>Matrix Metalloproteinase 13 - metabolism</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>neutralization</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phenols - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>sesame seed</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>tumor necrosis factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hemshekhar, Mahadevappa</creatorcontrib><creatorcontrib>Thushara, Ram Mohan</creatorcontrib><creatorcontrib>Jnaneshwari, Sadashivaiah</creatorcontrib><creatorcontrib>Devaraja, Sannaningaiah</creatorcontrib><creatorcontrib>Kemparaju, Kempaiah</creatorcontrib><creatorcontrib>Girish, Kesturu Subbaiah</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career and Technical Education (ProQuest Database)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hemshekhar, Mahadevappa</au><au>Thushara, Ram Mohan</au><au>Jnaneshwari, Sadashivaiah</au><au>Devaraja, Sannaningaiah</au><au>Kemparaju, Kempaiah</au><au>Girish, Kesturu Subbaiah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>52</volume><issue>7</issue><spage>1787</spage><epage>1799</epage><pages>1787-1799</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>PURPOSE: The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. METHODS: Arthritis was induced using Freund’s complete adjuvant to hind paw of experimental rats. The physical and biochemical alterations and its recovery by sesamol were assessed by measuring enzymatic and non-enzymatic mediators. Arthritis-induced inflammation, oxidative stress and their protective by sesamol were measured by determining the levels of pro-inflammatory cytokines and oxidative stress markers. RESULTS: In the present study, sesamol was demonstrated to alleviate arthritis-induced cartilage degeneration by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases (MMP-13, MMP-3 and MMP-9). It also protected bone resorption by reducing the elevated levels of bone joint exoglycosidases, cathepsin D and tartarate-resistant acid phosphatases. Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL-1β, IL-6, COX-2, PGE₂, ROS, and H₂O₂,) effectively. In addition, sesamol neutralizes arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase. CONCLUSION: Taken together, the study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Thus, sesamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23269651</pmid><doi>10.1007/s00394-012-0482-6</doi><tpages>13</tpages></addata></record> |
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| subjects | acid phosphatase Alanine Transaminase - blood Animals Anti-Inflammatory Agents - administration & dosage antioxidants Antioxidants - administration & dosage arthritis Arthritis, Experimental - drug therapy Aspartate Aminotransferases - blood Benzodioxoles - administration & dosage blood serum bone resorption cardiovascular diseases cartilage catalase Catalase - metabolism cathepsin D Chemistry Chemistry and Materials Science Cyclooxygenase 2 - metabolism diabetes extracellular matrix Extracellular Matrix - metabolism gelatinase A glutathione transferase Glutathione Transferase - metabolism homeostasis hyaluronoglucosaminidase hydrogen peroxide Hydrogen Peroxide - metabolism inflammation Inflammation Mediators - metabolism interleukin-1beta Interleukin-1beta - metabolism interleukin-6 Interleukin-6 - metabolism Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism neutralization Nutrition Original Contribution oxidative stress Oxidative Stress - drug effects Phenols - administration & dosage Rats Rats, Wistar Reactive Oxygen Species - metabolism sesame seed superoxide dismutase Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism tumor necrosis factors |
| title | Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status |
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