Organ differences in the impact of p27kip1 deficiency on carcinogenesis induced by N-methyl-N-nitrosourea

ABSTRACT To evaluate the impact of p27 on carcinogenesis in various organs, N‐methyl‐N‐nitrosourea (MNU), a direct‐acting alkylating agent, was given to p27 knock‐out mice. Groups of 20–40 male and female mice with null, hetero‐ or wild‐type p27 alleles were given drinking water containing 240 ppm M...

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Veröffentlicht in:	Journal of applied toxicology 2013-06, Vol.33 (6), p.471-479
Hauptverfasser:	Ogawa, Kumiko, Murasaki, Toshiya, Sugiura, Satoshi, Nakanishi, Makoto, Shirai, Tomoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogens Cell cycle Genotype & phenotype knockout mice lymphoma MNU p27 stomach Toxicology
Online-Zugang:	Volltext
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