Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery

ABSTRACT Purpose To investigate the effects of the particle size and surface coating on the cellular uptake of the polymeric nanoparticles for drug delivery across the physiological drug barrier with emphasis on the gastrointestinal (GI) barrier for oral chemotherapy and the blood–brain barrier (BBB...

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Veröffentlicht in:	Pharmaceutical research 2013-10, Vol.30 (10), p.2512-2522
Hauptverfasser:	Kulkarni, Sneha A., Feng, Si-Shen
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biochemistry Biodegradable materials Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood-brain barrier Blood-Brain Barrier - metabolism Caco-2 Cells Chemotherapy Chromatography, High Pressure Liquid Dogs Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug delivery systems Drug Delivery Systems - methods Endocytosis - physiology Fluorescent Dyes - chemistry Gastrointestinal Tract - metabolism Humans Madin Darby Canine Kidney Cells Male Medical Law Nanoparticles - chemistry Nanotechnology Particle Size Pharmacology/Toxicology Pharmacy Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polystyrenes - chemistry Polystyrenes - pharmacokinetics Rats Rats, Sprague-Dawley Research Paper Surface Properties Tissue Distribution Vitamin E - analogs & derivatives Vitamin E - chemistry Vitamin E - pharmacokinetics
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