Expression and clinical relevance of MET and ALK in Ewing sarcomas

Because novel therapeutic options are limited in Ewing sarcomas (ES), we investigated the expression, genetic aberrations and clinical relevance of MET and anaplastic lymphoma kinase (ALK) in ES and determined the relevance of targeting these receptors. MET and ALK protein expression was determined...

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Veröffentlicht in:	International journal of cancer 2013-07, Vol.133 (2), p.427-436
Hauptverfasser:	Fleuren, Emmy D.G., Roeffen, Melissa H.S., Leenders, William P., Flucke, Uta E., Vlenterie, Myrella, Schreuder, Hendrik W., Boerman, Otto C., Graaf, Winette T.A., Versleijen‐Jonkers, Yvonne M.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult ALK Angiogenesis Anilides - pharmacology Biological and medical sciences Cancer Child Child, Preschool Chromosome Aberrations Diseases of the osteoarticular system Ewing sarcoma Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Inhibitory Concentration 50 Male Medical sciences MET Metastasis Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis Proteins Proto-Oncogene Proteins c-met - metabolism Pyrazoles - pharmacology Pyridines - pharmacology Pyrimidines - pharmacology Receptor Protein-Tyrosine Kinases - metabolism Recurrence Sarcoma, Ewing - metabolism Tetrazolium Salts - pharmacology Thiazoles - pharmacology Treatment Outcome Tumors Tumors of striated muscle and skeleton Young Adult
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