Addition of interferon-[alpha] to the p53-SLP vaccine results in increased production of interferon-[gamma] in vaccinated colorectal cancer patients: A phase I/II clinical trial

We previously established safety and immunogenicity of a p53 synthetic long peptides (p53-SLP) vaccine. In the current trial, we investigated whether combination of interferon-alpha (IFN-[alpha]) with p53-SLP is both safe and able to improve the induced p53-specific IFN-[gamma] response. Eleven colo...

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Veröffentlicht in:	International journal of cancer 2013-04, Vol.132 (7), p.1581
Hauptverfasser:	Zeestraten, Eliane CM, Speetjens, Frank M, Welters, Marij JP, Saadatmand, Sepideh, Stynenbosch, Linda FM, Jongen, Rogier, Kapiteijn, Ellen, Gelderblom, Hans, Nijman, Hans W, Valentijn, A Rob PM, Oostendorp, Jaap, Fathers, Lorraine M, Drijfhout, Jan W, van de Velde, Cornelis JH, Kuppen, Peter JK, van der Burg, Sjoerd H, Melief, Cornelis JM
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Clinical trials Colorectal cancer Immunotherapy Interferon Lymphocytes Medical research Vaccines
Online-Zugang:	Volltext
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