Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma
We report a case of synchronous hepatocellular carcinoma (HCC) and malignant peritoneal mesothelioma (MM-per). A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. Partia...
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| Veröffentlicht in: | Medical molecular morphology 2013-09, Vol.46 (3), p.177-183 |
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| creator | Uemoto, Junko Hoshi, Nobuo Hirabayashi, Kaoru Hoshi, Sayuri Onodera, Kei Nishi, Tomohiro Tomikawa, Moriaki Igarashi, Seiji |
| description | We report a case of synchronous hepatocellular carcinoma (HCC) and malignant peritoneal mesothelioma (MM-per). A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. Partial hepatectomy, splenectomy, partial diaphragm resection, and partial gastrectomy were performed. The tumor in the lateral segment of the liver was gray to white, massive in appearance, and contained focal bile-producing nodules and extensive fibrous firm lesion. It had directly invaded the spleen and diaphragm. Liver cirrhosis was not found. The peritoneum contained multiple small nodules especially around the diaphragm, which mimicked carcinoma dissemination. After histological examination, the liver tumor was diagnosed as HCC. It had trabecular and scirrhous patterns and positive immunoreactivities for Hep-Par-1 and α-fetoprotein. The peritoneal nodules were diagnosed as MM-per, epithelioid type, with positive immunoreactivities for calretinin and cytokeratin 5/6. The two tumors collided around the diaphragm. Cases of MM synchronous with other primary malignant tumors have been reported, but most had a history of asbestos exposure unlike the present case. The carcinogenic background was unclear for two tumors in this case. This is an extremely rare and valuable case. |
| doi_str_mv | 10.1007/s00795-013-0041-0 |
| format | Article |
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A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. Partial hepatectomy, splenectomy, partial diaphragm resection, and partial gastrectomy were performed. The tumor in the lateral segment of the liver was gray to white, massive in appearance, and contained focal bile-producing nodules and extensive fibrous firm lesion. It had directly invaded the spleen and diaphragm. Liver cirrhosis was not found. The peritoneum contained multiple small nodules especially around the diaphragm, which mimicked carcinoma dissemination. After histological examination, the liver tumor was diagnosed as HCC. It had trabecular and scirrhous patterns and positive immunoreactivities for Hep-Par-1 and α-fetoprotein. The peritoneal nodules were diagnosed as MM-per, epithelioid type, with positive immunoreactivities for calretinin and cytokeratin 5/6. The two tumors collided around the diaphragm. Cases of MM synchronous with other primary malignant tumors have been reported, but most had a history of asbestos exposure unlike the present case. The carcinogenic background was unclear for two tumors in this case. This is an extremely rare and valuable case.</description><identifier>ISSN: 1860-1480</identifier><identifier>EISSN: 1860-1499</identifier><identifier>DOI: 10.1007/s00795-013-0041-0</identifier><identifier>PMID: 23571781</identifier><identifier>CODEN: MELMEJ</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Anatomy ; Asbestos ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - therapy ; Case Report ; Combined Modality Therapy ; Fatal Outcome ; Hepatitis ; Human exposure ; Humans ; Liver - pathology ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - therapy ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - therapy ; Male ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Mesothelioma - diagnostic imaging ; Mesothelioma - therapy ; Mesothelioma, Malignant ; Middle Aged ; Molecular Medicine ; Neoplasms, Multiple Primary - diagnostic imaging ; Neoplasms, Multiple Primary - therapy ; Pathology ; Peritoneal Neoplasms - diagnostic imaging ; Peritoneal Neoplasms - therapy ; Radiography</subject><ispartof>Medical molecular morphology, 2013-09, Vol.46 (3), p.177-183</ispartof><rights>The Japanese Society for Clinical Molecular Morphology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-b38fae0796d9cee1ddd79ba4b0bb4b023d25af2d85af69502da83d22c1bfaa903</citedby><cites>FETCH-LOGICAL-c425t-b38fae0796d9cee1ddd79ba4b0bb4b023d25af2d85af69502da83d22c1bfaa903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00795-013-0041-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00795-013-0041-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23571781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uemoto, Junko</creatorcontrib><creatorcontrib>Hoshi, Nobuo</creatorcontrib><creatorcontrib>Hirabayashi, Kaoru</creatorcontrib><creatorcontrib>Hoshi, Sayuri</creatorcontrib><creatorcontrib>Onodera, Kei</creatorcontrib><creatorcontrib>Nishi, Tomohiro</creatorcontrib><creatorcontrib>Tomikawa, Moriaki</creatorcontrib><creatorcontrib>Igarashi, Seiji</creatorcontrib><title>Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma</title><title>Medical molecular morphology</title><addtitle>Med Mol Morphol</addtitle><addtitle>Med Mol Morphol</addtitle><description>We report a case of synchronous hepatocellular carcinoma (HCC) and malignant peritoneal mesothelioma (MM-per). A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. Partial hepatectomy, splenectomy, partial diaphragm resection, and partial gastrectomy were performed. The tumor in the lateral segment of the liver was gray to white, massive in appearance, and contained focal bile-producing nodules and extensive fibrous firm lesion. It had directly invaded the spleen and diaphragm. Liver cirrhosis was not found. The peritoneum contained multiple small nodules especially around the diaphragm, which mimicked carcinoma dissemination. After histological examination, the liver tumor was diagnosed as HCC. It had trabecular and scirrhous patterns and positive immunoreactivities for Hep-Par-1 and α-fetoprotein. The peritoneal nodules were diagnosed as MM-per, epithelioid type, with positive immunoreactivities for calretinin and cytokeratin 5/6. The two tumors collided around the diaphragm. Cases of MM synchronous with other primary malignant tumors have been reported, but most had a history of asbestos exposure unlike the present case. The carcinogenic background was unclear for two tumors in this case. This is an extremely rare and valuable case.</description><subject>Anatomy</subject><subject>Asbestos</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Case Report</subject><subject>Combined Modality Therapy</subject><subject>Fatal Outcome</subject><subject>Hepatitis</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - therapy</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma - diagnostic imaging</subject><subject>Mesothelioma - therapy</subject><subject>Mesothelioma, Malignant</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms, Multiple Primary - diagnostic imaging</subject><subject>Neoplasms, Multiple Primary - therapy</subject><subject>Pathology</subject><subject>Peritoneal Neoplasms - diagnostic imaging</subject><subject>Peritoneal Neoplasms - therapy</subject><subject>Radiography</subject><issn>1860-1480</issn><issn>1860-1499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LAzEURYMotlZ_gBsJuB59SeZzKcUvKAii6_BmkmmnZJIxmVn4701pLW7c3ITk5D5yCLlmcMcAivsQo8oSYCIBSFkCJ2TOyhwSllbV6XFfwoxchLAFEEXOs3My4yIrWFGyOXlfOmO60DlLx6l3PlDX0o0ecHSNNmYy6GmDvums65GiVbRH060t2pEO2nejsxoN7XVw40abLlKX5KxFE_TVYV2Qz6fHj-VLsnp7fl0-rJIm5dmY1KJsUccP5KpqtGZKqaKqMa2hrmNwoXiGLVdlzLzKgCss4xlvWN0iViAW5HbfO3j3Nekwyq2bvI0jJUuFgKJIRRkptqca70LwupWD73r035KB3FmUe4syWpQ7i3LXfHNonupeq-OLX20R4HsgxCu71v7P6H9bfwB13H7I</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Uemoto, Junko</creator><creator>Hoshi, Nobuo</creator><creator>Hirabayashi, Kaoru</creator><creator>Hoshi, Sayuri</creator><creator>Onodera, Kei</creator><creator>Nishi, Tomohiro</creator><creator>Tomikawa, Moriaki</creator><creator>Igarashi, Seiji</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130901</creationdate><title>Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma</title><author>Uemoto, Junko ; Hoshi, Nobuo ; Hirabayashi, Kaoru ; Hoshi, Sayuri ; Onodera, Kei ; Nishi, Tomohiro ; Tomikawa, Moriaki ; Igarashi, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-b38fae0796d9cee1ddd79ba4b0bb4b023d25af2d85af69502da83d22c1bfaa903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anatomy</topic><topic>Asbestos</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Case Report</topic><topic>Combined Modality Therapy</topic><topic>Fatal Outcome</topic><topic>Hepatitis</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - therapy</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesothelioma - diagnostic imaging</topic><topic>Mesothelioma - therapy</topic><topic>Mesothelioma, Malignant</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasms, Multiple Primary - diagnostic imaging</topic><topic>Neoplasms, Multiple Primary - therapy</topic><topic>Pathology</topic><topic>Peritoneal Neoplasms - diagnostic imaging</topic><topic>Peritoneal Neoplasms - therapy</topic><topic>Radiography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uemoto, Junko</creatorcontrib><creatorcontrib>Hoshi, Nobuo</creatorcontrib><creatorcontrib>Hirabayashi, Kaoru</creatorcontrib><creatorcontrib>Hoshi, Sayuri</creatorcontrib><creatorcontrib>Onodera, Kei</creatorcontrib><creatorcontrib>Nishi, Tomohiro</creatorcontrib><creatorcontrib>Tomikawa, Moriaki</creatorcontrib><creatorcontrib>Igarashi, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Medical molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uemoto, Junko</au><au>Hoshi, Nobuo</au><au>Hirabayashi, Kaoru</au><au>Hoshi, Sayuri</au><au>Onodera, Kei</au><au>Nishi, Tomohiro</au><au>Tomikawa, Moriaki</au><au>Igarashi, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma</atitle><jtitle>Medical molecular morphology</jtitle><stitle>Med Mol Morphol</stitle><addtitle>Med Mol Morphol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>46</volume><issue>3</issue><spage>177</spage><epage>183</epage><pages>177-183</pages><issn>1860-1480</issn><eissn>1860-1499</eissn><coden>MELMEJ</coden><abstract>We report a case of synchronous hepatocellular carcinoma (HCC) and malignant peritoneal mesothelioma (MM-per). A 56-year-old man with no past history of asbestos exposure, chronic viral hepatitis, or alcoholic liver injury was admitted to our hospital with left flank pain and abdominal tumor. Partial hepatectomy, splenectomy, partial diaphragm resection, and partial gastrectomy were performed. The tumor in the lateral segment of the liver was gray to white, massive in appearance, and contained focal bile-producing nodules and extensive fibrous firm lesion. It had directly invaded the spleen and diaphragm. Liver cirrhosis was not found. The peritoneum contained multiple small nodules especially around the diaphragm, which mimicked carcinoma dissemination. After histological examination, the liver tumor was diagnosed as HCC. It had trabecular and scirrhous patterns and positive immunoreactivities for Hep-Par-1 and α-fetoprotein. The peritoneal nodules were diagnosed as MM-per, epithelioid type, with positive immunoreactivities for calretinin and cytokeratin 5/6. The two tumors collided around the diaphragm. Cases of MM synchronous with other primary malignant tumors have been reported, but most had a history of asbestos exposure unlike the present case. The carcinogenic background was unclear for two tumors in this case. This is an extremely rare and valuable case.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23571781</pmid><doi>10.1007/s00795-013-0041-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Anatomy Asbestos Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - therapy Case Report Combined Modality Therapy Fatal Outcome Hepatitis Human exposure Humans Liver - pathology Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - therapy Lung Neoplasms - diagnostic imaging Lung Neoplasms - therapy Male Medical diagnosis Medicine Medicine & Public Health Mesothelioma - diagnostic imaging Mesothelioma - therapy Mesothelioma, Malignant Middle Aged Molecular Medicine Neoplasms, Multiple Primary - diagnostic imaging Neoplasms, Multiple Primary - therapy Pathology Peritoneal Neoplasms - diagnostic imaging Peritoneal Neoplasms - therapy Radiography |
| title | Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma |
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