Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A
Background: Although respiratory viral infections cause acute exacerbations of asthma, the inflammatory responses vary depending on the causative virus. The purpose of this study was to compare the inflammatory responses in the airways of acute exacerbations of asthma induced by respiratory syncytia...
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| Veröffentlicht in: | International archives of allergy and immunology 2013-01, Vol.161 (4), p.378-382 |
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| creator | Matsuse, Hiroto Tsuchida, Tomoko Fukahori, Susumu Kawano, Tetsuya Tomari, Shinya Matsuo, Nobuko Nishino, Tomoya Fukushima, Chizu Kohno, Shigeru |
| description | Background: Although respiratory viral infections cause acute exacerbations of asthma, the inflammatory responses vary depending on the causative virus. The purpose of this study was to compare the inflammatory responses in the airways of acute exacerbations of asthma induced by respiratory syncytial virus (RSV) and influenza A virus. Methods: Sputum induction was performed in asthmatic patients with acute exacerbations induced by RSV (n = 6), influenza A (n = 7), and non-upper respiratory infection (URI)-related factors (n = 8). Sputum concentrations of cysteinyl leukotrienes (cysLTs), TNF-α and IFN-γ were measured. Results: Sputum cysLTs were significantly higher in RSV-induced exacerbations than in influenza A- and non-URI-induced exacerbations. Sputum TNF-α was significantly higher in influenza A-induced exacerbations than in RSV- and non-URI-induced exacerbations. Sputum IFN-γ was significantly lower in RSV-induced exacerbations than in the others. Conclusions: RSV and influenza A cause acute exacerbations and have different effects on airway inflammation in asthmatic patients. RSV significantly increased cysLTs, while influenza A significantly increased TNF-α in the airway. The underlying mechanism in virus-induced asthma might depend on the viral species. |
| doi_str_mv | 10.1159/000348381 |
| format | Article |
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The purpose of this study was to compare the inflammatory responses in the airways of acute exacerbations of asthma induced by respiratory syncytial virus (RSV) and influenza A virus. Methods: Sputum induction was performed in asthmatic patients with acute exacerbations induced by RSV (n = 6), influenza A (n = 7), and non-upper respiratory infection (URI)-related factors (n = 8). Sputum concentrations of cysteinyl leukotrienes (cysLTs), TNF-α and IFN-γ were measured. Results: Sputum cysLTs were significantly higher in RSV-induced exacerbations than in influenza A- and non-URI-induced exacerbations. Sputum TNF-α was significantly higher in influenza A-induced exacerbations than in RSV- and non-URI-induced exacerbations. Sputum IFN-γ was significantly lower in RSV-induced exacerbations than in the others. Conclusions: RSV and influenza A cause acute exacerbations and have different effects on airway inflammation in asthmatic patients. RSV significantly increased cysLTs, while influenza A significantly increased TNF-α in the airway. The underlying mechanism in virus-induced asthma might depend on the viral species.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000348381</identifier><identifier>PMID: 23689185</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Asthma ; Asthma - complications ; Asthma - immunology ; Disease Progression ; Female ; Humans ; Influenza ; Influenza A virus ; Influenza A virus - immunology ; Influenza A virus - pathogenicity ; Influenza, Human - complications ; Influenza, Human - immunology ; Interferon-gamma - metabolism ; Leukotriene D4 - metabolism ; Male ; Middle Aged ; Original Paper ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - complications ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Viruses - immunology ; Respiratory Syncytial Viruses - pathogenicity ; Sputum - metabolism ; Tumor Necrosis Factor-alpha - metabolism ; Viruses</subject><ispartof>International archives of allergy and immunology, 2013-01, Vol.161 (4), p.378-382</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 S. Karger AG, Basel.</rights><rights>Copyright (c) 2013 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-f69942e6876056512b91b9edefb6bda653fff79d5f2cac8f1e74eca30f11f2d63</citedby><cites>FETCH-LOGICAL-c433t-f69942e6876056512b91b9edefb6bda653fff79d5f2cac8f1e74eca30f11f2d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23689185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuse, Hiroto</creatorcontrib><creatorcontrib>Tsuchida, Tomoko</creatorcontrib><creatorcontrib>Fukahori, Susumu</creatorcontrib><creatorcontrib>Kawano, Tetsuya</creatorcontrib><creatorcontrib>Tomari, Shinya</creatorcontrib><creatorcontrib>Matsuo, Nobuko</creatorcontrib><creatorcontrib>Nishino, Tomoya</creatorcontrib><creatorcontrib>Fukushima, Chizu</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><title>Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: Although respiratory viral infections cause acute exacerbations of asthma, the inflammatory responses vary depending on the causative virus. The purpose of this study was to compare the inflammatory responses in the airways of acute exacerbations of asthma induced by respiratory syncytial virus (RSV) and influenza A virus. Methods: Sputum induction was performed in asthmatic patients with acute exacerbations induced by RSV (n = 6), influenza A (n = 7), and non-upper respiratory infection (URI)-related factors (n = 8). Sputum concentrations of cysteinyl leukotrienes (cysLTs), TNF-α and IFN-γ were measured. Results: Sputum cysLTs were significantly higher in RSV-induced exacerbations than in influenza A- and non-URI-induced exacerbations. Sputum TNF-α was significantly higher in influenza A-induced exacerbations than in RSV- and non-URI-induced exacerbations. Sputum IFN-γ was significantly lower in RSV-induced exacerbations than in the others. Conclusions: RSV and influenza A cause acute exacerbations and have different effects on airway inflammation in asthmatic patients. RSV significantly increased cysLTs, while influenza A significantly increased TNF-α in the airway. The underlying mechanism in virus-induced asthma might depend on the viral species.</description><subject>Adult</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - immunology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza A virus</subject><subject>Influenza A virus - immunology</subject><subject>Influenza A virus - pathogenicity</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Leukotriene D4 - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - complications</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Viruses - immunology</subject><subject>Respiratory Syncytial Viruses - pathogenicity</subject><subject>Sputum - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Viruses</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0btP3TAUBnALFfEqAztCkVhgSOtH7Njj1S0vCQmprzVynOPWkDgXOxENS__1GnK5A0snW_bvfNLRh9ARwZ8I4eozxpgVkkmyhfZIQVmOsSo_pDsmMqcFk7toP8Z7jBOWYgftUiakIpLvob9fnLUQwA9Ot9nChSc9ZTfetrrr9NCHKfsKcdX7CDFzPlvE4Xens4s_2kCo9eDST-LNaKDJ6hm7MA9-m7yZXmN_ujDGTPvmNXkE_6zXb4uPaNvqNsLh-jxAPy4vvi-v89u7q5vl4jY3BWNDboVSBQUhS4G54ITWitQKGrC1qBstOLPWlqrhlhptpCVQFmA0w5YQSxvBDtDZnLsK_eMIcag6Fw20rfbQj7EipZBcYonV_2mBCVaEUpno6Tt634_Bp0WSooLzVARP6nxWJvQxBrDVKrhOh6kiuHopsNoUmOzJOnGsO2g28q2xBI5n8KDDLwgbsJ7_B4MYn4k</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Matsuse, Hiroto</creator><creator>Tsuchida, Tomoko</creator><creator>Fukahori, Susumu</creator><creator>Kawano, Tetsuya</creator><creator>Tomari, Shinya</creator><creator>Matsuo, Nobuko</creator><creator>Nishino, Tomoya</creator><creator>Fukushima, Chizu</creator><creator>Kohno, Shigeru</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A</title><author>Matsuse, Hiroto ; Tsuchida, Tomoko ; Fukahori, Susumu ; Kawano, Tetsuya ; Tomari, Shinya ; Matsuo, Nobuko ; Nishino, Tomoya ; Fukushima, Chizu ; Kohno, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-f69942e6876056512b91b9edefb6bda653fff79d5f2cac8f1e74eca30f11f2d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - immunology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Influenza</topic><topic>Influenza A virus</topic><topic>Influenza A virus - immunology</topic><topic>Influenza A virus - pathogenicity</topic><topic>Influenza, Human - complications</topic><topic>Influenza, Human - immunology</topic><topic>Interferon-gamma - metabolism</topic><topic>Leukotriene D4 - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - complications</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Viruses - immunology</topic><topic>Respiratory Syncytial Viruses - pathogenicity</topic><topic>Sputum - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuse, Hiroto</creatorcontrib><creatorcontrib>Tsuchida, Tomoko</creatorcontrib><creatorcontrib>Fukahori, Susumu</creatorcontrib><creatorcontrib>Kawano, Tetsuya</creatorcontrib><creatorcontrib>Tomari, Shinya</creatorcontrib><creatorcontrib>Matsuo, Nobuko</creatorcontrib><creatorcontrib>Nishino, Tomoya</creatorcontrib><creatorcontrib>Fukushima, Chizu</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International archives of allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuse, Hiroto</au><au>Tsuchida, Tomoko</au><au>Fukahori, Susumu</au><au>Kawano, Tetsuya</au><au>Tomari, Shinya</au><au>Matsuo, Nobuko</au><au>Nishino, Tomoya</au><au>Fukushima, Chizu</au><au>Kohno, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>161</volume><issue>4</issue><spage>378</spage><epage>382</epage><pages>378-382</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>Background: Although respiratory viral infections cause acute exacerbations of asthma, the inflammatory responses vary depending on the causative virus. The purpose of this study was to compare the inflammatory responses in the airways of acute exacerbations of asthma induced by respiratory syncytial virus (RSV) and influenza A virus. Methods: Sputum induction was performed in asthmatic patients with acute exacerbations induced by RSV (n = 6), influenza A (n = 7), and non-upper respiratory infection (URI)-related factors (n = 8). Sputum concentrations of cysteinyl leukotrienes (cysLTs), TNF-α and IFN-γ were measured. Results: Sputum cysLTs were significantly higher in RSV-induced exacerbations than in influenza A- and non-URI-induced exacerbations. Sputum TNF-α was significantly higher in influenza A-induced exacerbations than in RSV- and non-URI-induced exacerbations. Sputum IFN-γ was significantly lower in RSV-induced exacerbations than in the others. Conclusions: RSV and influenza A cause acute exacerbations and have different effects on airway inflammation in asthmatic patients. RSV significantly increased cysLTs, while influenza A significantly increased TNF-α in the airway. The underlying mechanism in virus-induced asthma might depend on the viral species.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>23689185</pmid><doi>10.1159/000348381</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Asthma Asthma - complications Asthma - immunology Disease Progression Female Humans Influenza Influenza A virus Influenza A virus - immunology Influenza A virus - pathogenicity Influenza, Human - complications Influenza, Human - immunology Interferon-gamma - metabolism Leukotriene D4 - metabolism Male Middle Aged Original Paper Respiratory syncytial virus Respiratory Syncytial Virus Infections - complications Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Viruses - immunology Respiratory Syncytial Viruses - pathogenicity Sputum - metabolism Tumor Necrosis Factor-alpha - metabolism Viruses |
| title | Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A |
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