Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Base oxidation by endogenous and environmentally induced reactive oxygen species preferentially occurs in replicating single-stranded templates in mammalian genomes, warranting prereplicative repair of the mutagenic base lesions. It is not clear how such lesions (which, unlike bulky adducts, do not...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (33), p.E3090-E3099
Hauptverfasser:	Hegde, Muralidhar L, Hegde, Pavana M, Bellot, Larry J, Mandal, Santi M, Hazra, Tapas K, Li, Guo-Min, Boldogh, Istvan, Tomkinson, Alan E, Mitra, Sankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blotting, Western Bromodeoxyuridine Cells Chromatin Immunoprecipitation deamination DNA Glycosylases - metabolism DNA polymerase DNA Polymerase III - metabolism DNA Repair - genetics DNA replication DNA Replication - physiology DNA-directed DNA polymerase genome Genome, Human - genetics Genomes Genotype & phenotype glycosylases HEK293 Cells Humans Immunoprecipitation interphase Microscopy, Fluorescence mutagenicity Oxidation Oxidative Stress - genetics Oxidative Stress - physiology phenotype PNAS Plus Proteins reactive oxygen species RNA, Small Interfering - genetics single-stranded DNA
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