Erythropoiesis- and Thrombopoiesis-Characterizing Parameters in Adenosine A^sub 3^ Receptor Knock-Out Mice
Influence of the regulatory system mediated by adenosine A3 receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adeno...
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| Veröffentlicht in: | Physiological research 2013-05, Vol.62 (3), p.305 |
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| creator | Hofer, M Pospísil, M Dusek, L Hoferová, Z Weiterová, L Komurková, D |
| description | Influence of the regulatory system mediated by adenosine A3 receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A3 receptor knock-out (Adora3tml;lbs7Adora3,nll-lbsn, AsAR'7"') mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A3AR'7"' mice. In addition, adenosine A3 receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling. [PUBLICATION ABSTRACT] |
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Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A3AR'7"' mice. In addition, adenosine A3 receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling. 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| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenosine Blood Blood platelets Bone marrow Breeding of animals Cell cycle Confidence intervals Laboratory animals Rodents Studies |
| title | Erythropoiesis- and Thrombopoiesis-Characterizing Parameters in Adenosine A^sub 3^ Receptor Knock-Out Mice |
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