The timing of TGF-[beta] inhibition affects the generation of antigen-specific CD8+ T Cells

Transforming growth factor (TGF)-[beta] is a potent immunosuppressive cytokine necessary for cancer growth. Animal and human studies have shown that pharmacologic inhibition of TGF-[beta] slows the growth rate of established tumors and occasionally eradicates them altogether. We observed, paradoxica...

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Veröffentlicht in:	BMC immunology 2013-07, Vol.14
Hauptverfasser:	Quatromoni, Jon G, Suzuki, Eiji, Okusanya, Olugbenga, Judy, Brendan F, Bhojnagarwala, Pratik, Venegas, Ollin, Eruslanov, Evgeniy, Predina, Jarrod D, Albelda, Steven M, Singhal, Sunil
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioassays Biological response modifiers Cancer CD8 lymphocytes Colleges & universities Cytokines Cytotoxicity Hypotheses Immune response Immune system Laboratory animals Ligands Lymphocytes Medical research Medicine Phosphorylation Physiological aspects Rodents Thoracic surgery Transforming growth factors Tumors
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