Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat
The aim of the study was to evaluate a protective effect of apple juice on KBrO3‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO3. Markers o...
Gespeichert in:
| Veröffentlicht in: | Phytotherapy research 2013-08, Vol.27 (8), p.1214-1219 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1219 |
|---|---|
| container_issue | 8 |
| container_start_page | 1214 |
| container_title | Phytotherapy research |
| container_volume | 27 |
| creator | Kujawska, Małgorzata Ignatowicz, Ewa Ewertowska, Małgorzata Adamska, Teresa Markowski, Jarosław Jodynis-Liebert, Jadwiga |
| description | The aim of the study was to evaluate a protective effect of apple juice on KBrO3‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO3. Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior to KBrO3 challenge prevented an increase in hepatic and renal microsomal lipid peroxidation by 25 and 44%, respectively, increased the activity of antioxidant enzymes in the liver by 29 – 59% and decreased the plasma content of carbonyl groups by 19%. Aminotransferases activity in plasma was reduced by 19% and 36%, concentrations of plasma bilirubin, cholesterol and creatinine were suppressed by 21%, 16% and 26%, respectively, in rats supplemented with juice before KBrO3 injection. No protective effect of apple juice on nuclear DNA was observed. Supplementation with cloudy apple juice to some extent attenuated oxidative damage induced by KBrO3 in the liver and kidney of rats as evidenced by alterations of certain oxidative stress markers and clinical chemistry parameters. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.4848 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_1410680613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3025339921</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3818-5f4474168da30805b2800430733b2d110dc259d02c2778ea6dcf47cd0c914d733</originalsourceid><addsrcrecordid>eNpF0EtLw0AQwPFFFFsf4CeQBc-ps48km2MbtA9LK6VSb8t2dwOpaRLzwObbm9BaT3OYH8PwR-iBwIAA0Oe8KgZccHGB-gSCwCGuzy5RHwKXOJyIzx66KcsdAAQU-DXqUQacuoL10XpYVTatVRVnKc4i_DYqlsyZpqbW1uCVTVWCVWrwxOat0XidHWIdVw0eNThMsto0eJjnicWzOtYWT1O8UtUduopUUtr707xFH68v63DizJfjaTicOzETRDhuxLnPiSeMYiDA3VIBwBn4jG2pIQSMpm5ggGrq-8Iqz-iI-9qADgg3rbpFT8e7eZF917as5C6ri_blUhJOwBPgkU49nlS93Vsj8yLeq6KRfxFa4BzBT5zY5rwnILu4so0ru7jyfb3q5r-Py8oezl4VX9Lzme_KzWIsuTcJZ6tNKBfsF4kHd5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1410680613</pqid></control><display><type>article</type><title>Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Kujawska, Małgorzata ; Ignatowicz, Ewa ; Ewertowska, Małgorzata ; Adamska, Teresa ; Markowski, Jarosław ; Jodynis-Liebert, Jadwiga</creator><creatorcontrib>Kujawska, Małgorzata ; Ignatowicz, Ewa ; Ewertowska, Małgorzata ; Adamska, Teresa ; Markowski, Jarosław ; Jodynis-Liebert, Jadwiga</creatorcontrib><description>The aim of the study was to evaluate a protective effect of apple juice on KBrO3‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO3. Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior to KBrO3 challenge prevented an increase in hepatic and renal microsomal lipid peroxidation by 25 and 44%, respectively, increased the activity of antioxidant enzymes in the liver by 29 – 59% and decreased the plasma content of carbonyl groups by 19%. Aminotransferases activity in plasma was reduced by 19% and 36%, concentrations of plasma bilirubin, cholesterol and creatinine were suppressed by 21%, 16% and 26%, respectively, in rats supplemented with juice before KBrO3 injection. No protective effect of apple juice on nuclear DNA was observed. Supplementation with cloudy apple juice to some extent attenuated oxidative damage induced by KBrO3 in the liver and kidney of rats as evidenced by alterations of certain oxidative stress markers and clinical chemistry parameters. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4848</identifier><identifier>PMID: 23042583</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; antioxidant enzymes ; Antioxidants - metabolism ; Beverages ; Biomarkers - blood ; Bromates - adverse effects ; comet assay ; Kidney - drug effects ; Kidney - enzymology ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - enzymology ; Male ; Malus - chemistry ; Microsomes, Liver - drug effects ; Oxidation-Reduction ; Oxidative Stress - drug effects ; protein carbonyl groups ; Rats ; Rats, Wistar</subject><ispartof>Phytotherapy research, 2013-08, Vol.27 (8), p.1214-1219</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4848$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4848$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23042583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kujawska, Małgorzata</creatorcontrib><creatorcontrib>Ignatowicz, Ewa</creatorcontrib><creatorcontrib>Ewertowska, Małgorzata</creatorcontrib><creatorcontrib>Adamska, Teresa</creatorcontrib><creatorcontrib>Markowski, Jarosław</creatorcontrib><creatorcontrib>Jodynis-Liebert, Jadwiga</creatorcontrib><title>Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The aim of the study was to evaluate a protective effect of apple juice on KBrO3‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO3. Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior to KBrO3 challenge prevented an increase in hepatic and renal microsomal lipid peroxidation by 25 and 44%, respectively, increased the activity of antioxidant enzymes in the liver by 29 – 59% and decreased the plasma content of carbonyl groups by 19%. Aminotransferases activity in plasma was reduced by 19% and 36%, concentrations of plasma bilirubin, cholesterol and creatinine were suppressed by 21%, 16% and 26%, respectively, in rats supplemented with juice before KBrO3 injection. No protective effect of apple juice on nuclear DNA was observed. Supplementation with cloudy apple juice to some extent attenuated oxidative damage induced by KBrO3 in the liver and kidney of rats as evidenced by alterations of certain oxidative stress markers and clinical chemistry parameters. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>antioxidant enzymes</subject><subject>Antioxidants - metabolism</subject><subject>Beverages</subject><subject>Biomarkers - blood</subject><subject>Bromates - adverse effects</subject><subject>comet assay</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Malus - chemistry</subject><subject>Microsomes, Liver - drug effects</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress - drug effects</subject><subject>protein carbonyl groups</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLw0AQwPFFFFsf4CeQBc-ps48km2MbtA9LK6VSb8t2dwOpaRLzwObbm9BaT3OYH8PwR-iBwIAA0Oe8KgZccHGB-gSCwCGuzy5RHwKXOJyIzx66KcsdAAQU-DXqUQacuoL10XpYVTatVRVnKc4i_DYqlsyZpqbW1uCVTVWCVWrwxOat0XidHWIdVw0eNThMsto0eJjnicWzOtYWT1O8UtUduopUUtr707xFH68v63DizJfjaTicOzETRDhuxLnPiSeMYiDA3VIBwBn4jG2pIQSMpm5ggGrq-8Iqz-iI-9qADgg3rbpFT8e7eZF917as5C6ri_blUhJOwBPgkU49nlS93Vsj8yLeq6KRfxFa4BzBT5zY5rwnILu4so0ru7jyfb3q5r-Py8oezl4VX9Lzme_KzWIsuTcJZ6tNKBfsF4kHd5A</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Kujawska, Małgorzata</creator><creator>Ignatowicz, Ewa</creator><creator>Ewertowska, Małgorzata</creator><creator>Adamska, Teresa</creator><creator>Markowski, Jarosław</creator><creator>Jodynis-Liebert, Jadwiga</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201308</creationdate><title>Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat</title><author>Kujawska, Małgorzata ; Ignatowicz, Ewa ; Ewertowska, Małgorzata ; Adamska, Teresa ; Markowski, Jarosław ; Jodynis-Liebert, Jadwiga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3818-5f4474168da30805b2800430733b2d110dc259d02c2778ea6dcf47cd0c914d733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>antioxidant enzymes</topic><topic>Antioxidants - metabolism</topic><topic>Beverages</topic><topic>Biomarkers - blood</topic><topic>Bromates - adverse effects</topic><topic>comet assay</topic><topic>Kidney - drug effects</topic><topic>Kidney - enzymology</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Malus - chemistry</topic><topic>Microsomes, Liver - drug effects</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress - drug effects</topic><topic>protein carbonyl groups</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kujawska, Małgorzata</creatorcontrib><creatorcontrib>Ignatowicz, Ewa</creatorcontrib><creatorcontrib>Ewertowska, Małgorzata</creatorcontrib><creatorcontrib>Adamska, Teresa</creatorcontrib><creatorcontrib>Markowski, Jarosław</creatorcontrib><creatorcontrib>Jodynis-Liebert, Jadwiga</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kujawska, Małgorzata</au><au>Ignatowicz, Ewa</au><au>Ewertowska, Małgorzata</au><au>Adamska, Teresa</au><au>Markowski, Jarosław</au><au>Jodynis-Liebert, Jadwiga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2013-08</date><risdate>2013</risdate><volume>27</volume><issue>8</issue><spage>1214</spage><epage>1219</epage><pages>1214-1219</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The aim of the study was to evaluate a protective effect of apple juice on KBrO3‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO3. Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior to KBrO3 challenge prevented an increase in hepatic and renal microsomal lipid peroxidation by 25 and 44%, respectively, increased the activity of antioxidant enzymes in the liver by 29 – 59% and decreased the plasma content of carbonyl groups by 19%. Aminotransferases activity in plasma was reduced by 19% and 36%, concentrations of plasma bilirubin, cholesterol and creatinine were suppressed by 21%, 16% and 26%, respectively, in rats supplemented with juice before KBrO3 injection. No protective effect of apple juice on nuclear DNA was observed. Supplementation with cloudy apple juice to some extent attenuated oxidative damage induced by KBrO3 in the liver and kidney of rats as evidenced by alterations of certain oxidative stress markers and clinical chemistry parameters. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23042583</pmid><doi>10.1002/ptr.4848</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 2013-08, Vol.27 (8), p.1214-1219 |
| issn | 0951-418X 1099-1573 |
| language | eng |
| recordid | cdi_proquest_journals_1410680613 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals antioxidant enzymes Antioxidants - metabolism Beverages Biomarkers - blood Bromates - adverse effects comet assay Kidney - drug effects Kidney - enzymology lipid peroxidation Lipid Peroxidation - drug effects Liver - drug effects Liver - enzymology Male Malus - chemistry Microsomes, Liver - drug effects Oxidation-Reduction Oxidative Stress - drug effects protein carbonyl groups Rats Rats, Wistar |
| title | Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A52%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Attenuation%20of%20KBrO3-Induced%20Renal%20and%20Hepatic%20Toxicity%20By%20Cloudy%20Apple%20Juice%20In%20Rat&rft.jtitle=Phytotherapy%20research&rft.au=Kujawska,%20Ma%C5%82gorzata&rft.date=2013-08&rft.volume=27&rft.issue=8&rft.spage=1214&rft.epage=1219&rft.pages=1214-1219&rft.issn=0951-418X&rft.eissn=1099-1573&rft.coden=PHYREH&rft_id=info:doi/10.1002/ptr.4848&rft_dat=%3Cproquest_pubme%3E3025339921%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1410680613&rft_id=info:pmid/23042583&rfr_iscdi=true |