Fatal vincristine-induced acute neurotoxicity mimicking Guillain-Barré syndrome

Fatal vincristine-induced acute neurotoxicity mimicking Guillain-Barré syndrome

Vincristine (VCR) is a chemotherapeutic agent commonly cause distal axonal degeneration in a dose-related fashion by binding to tubulin and thereby blocking its polymerization into microtubules. [1] VCR has been linked to the development of sensory-motor axonal polyneuropathy, autonomic neuropathy a...

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Veröffentlicht in:Journal of cancer research and therapeutics 2013-04, Vol.9 (2), p.335-336
Hauptverfasser: Tazi, Illias, Nafil, Hatim, Zaoui, Sanaa, Mahmal, Lahoucine
Format: Artikel
Sprache:eng
Schlagworte:
Chemotherapy
Complications and side effects
Development and progression
Diagnosis
Diagnosis, Differential
Guillain-Barre syndrome
Guillain-Barre Syndrome - chemically induced
Guillain-Barre Syndrome - diagnosis
Guillain-Barre Syndrome - pathology
Humans
Male
Middle Aged
Mortality
Neurotoxicity
Neurotoxicity syndromes
Neurotoxicity Syndromes - diagnosis
Neurotoxicity Syndromes - etiology
Neurotoxicity Syndromes - pathology
Pharmaceuticals
Risk factors
Vincristine
Vincristine - adverse effects
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Zusammenfassung:Vincristine (VCR) is a chemotherapeutic agent commonly cause distal axonal degeneration in a dose-related fashion by binding to tubulin and thereby blocking its polymerization into microtubules. [1] VCR has been linked to the development of sensory-motor axonal polyneuropathy, autonomic neuropathy and cranial nerve neuropathies in a dose-dependent manner.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.113427