The TEAD4-YAP/TAZ Protein-Protein Interaction: Expected Similarities and Unexpected Differences

The Hippo pathway controls cell homeostasis, and its deregulation can lead to human diseases. In this pathway, the YAP and TAZ transcriptional cofactors play a key role in stimulating gene transcription through their interaction with the TEAD transcriptional factors. Our study of YAP and TAZ peptide...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2013-07, Vol.14 (10), p.1218-1225
Hauptverfasser:	Hau, Jean Christophe, Erdmann, Dirk, Mesrouze, Yannick, Furet, Pascal, Fontana, Patrizia, Zimmermann, Catherine, Schmelzle, Tobias, Hofmann, Francesco, Chène, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding sites DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Hippo pathway Humans Immunohistochemistry Mice Models, Molecular Molecular Sequence Data Muscle Proteins - chemistry Muscle Proteins - genetics Muscle Proteins - metabolism Mutagenesis, Site-Directed omega loops peptides Peptides - chemistry Peptides - genetics Peptides - metabolism Protein Interaction Domains and Motifs protein-protein interactions Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Sequence Homology, Amino Acid Signal Transduction TAZ TEAD Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism YAP
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