Interactions of laulimalide, peloruside, and their derivatives with the isoforms of [Beta]-tubulin

The investigational anticancer agents laulimalide and peloruside are known to exert an antimitotic effect on cells by binding to β-tubulin. The binding affinities of derivatives of laulimalide and peloruside to all known isoforms of human β-tubulin were calculated using molecular mechanical, molecul...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Canadian journal of chemistry 2013-07, Vol.91 (7), p.511
Hauptverfasser:	Gajewski, Melissa M, Tuszynski, Jack A, Barakat, Khaled, Huzil, J Torin, Klobukowski, Mariusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Effects Molecular structure Proteins Quantum physics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!