Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab

Abstract We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude t...

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Veröffentlicht in:	Modern rheumatology 2012-08, Vol.22 (4), p.621-624
Hauptverfasser:	Takezaki, Shunichiro, Okura, Yuka, Ichikawa, Mizuho, Suzuki, Daisuke, Ohshima, Junjiro, Kaneda, Makoto, Cho, Yuko, Yamada, Masafumi, Kawamura, Nobuaki, Iguchi, Akihiro, Kobayashi, Ichiro, Ariga, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antirheumatic Agents - therapeutic use Arthritis Arthritis, Juvenile - complications Arthritis, Juvenile - drug therapy Arthritis, Juvenile - pathology Cancer Combined Modality Therapy Drug Substitution Germinoma - complications Germinoma - pathology Germinoma - therapy Glucocorticoids - therapeutic use Humans Infliximab Male Mediastinal Neoplasms - complications Mediastinal Neoplasms - pathology Mediastinal Neoplasms - therapy Medical treatment Monoclonal antibodies Prednisolone - therapeutic use Rheumatology Risk assessment TNF inhibitors Treatment Outcome Young Adult
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