Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab
Abstract We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude t...
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| Veröffentlicht in: | Modern rheumatology 2012-08, Vol.22 (4), p.621-624 |
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| container_end_page | 624 |
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| container_issue | 4 |
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| container_title | Modern rheumatology |
| container_volume | 22 |
| creator | Takezaki, Shunichiro Okura, Yuka Ichikawa, Mizuho Suzuki, Daisuke Ohshima, Junjiro Kaneda, Makoto Cho, Yuko Yamada, Masafumi Kawamura, Nobuaki Iguchi, Akihiro Kobayashi, Ichiro Ariga, Tadashi |
| description | Abstract
We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude that the indications for tumor necrosis factor (TNF) inhibitors should be strictly decided and that a nationwide cohort study is necessary to assess the risk of cancer in patients with JIA exposed to biologics. |
| doi_str_mv | 10.3109/s10165-011-0555-z |
| format | Article |
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We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude that the indications for tumor necrosis factor (TNF) inhibitors should be strictly decided and that a nationwide cohort study is necessary to assess the risk of cancer in patients with JIA exposed to biologics.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.3109/s10165-011-0555-z</identifier><language>eng</language><publisher>Tokyo: Informa Healthcare</publisher><subject>Arthritis ; Cancer ; Medical treatment ; Monoclonal antibodies ; Rheumatology ; Risk assessment ; TNF inhibitors</subject><ispartof>Modern rheumatology, 2012-08, Vol.22 (4), p.621-624</ispartof><rights>2012 Japan College of Rheumatology 2012</rights><rights>Copyright Springer Science & Business Media Aug 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1752-5a350689d2d84ae969a23eca5528338ad9ff00bef4f5ec2a46595f32d51edad43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Takezaki, Shunichiro</creatorcontrib><creatorcontrib>Okura, Yuka</creatorcontrib><creatorcontrib>Ichikawa, Mizuho</creatorcontrib><creatorcontrib>Suzuki, Daisuke</creatorcontrib><creatorcontrib>Ohshima, Junjiro</creatorcontrib><creatorcontrib>Kaneda, Makoto</creatorcontrib><creatorcontrib>Cho, Yuko</creatorcontrib><creatorcontrib>Yamada, Masafumi</creatorcontrib><creatorcontrib>Kawamura, Nobuaki</creatorcontrib><creatorcontrib>Iguchi, Akihiro</creatorcontrib><creatorcontrib>Kobayashi, Ichiro</creatorcontrib><creatorcontrib>Ariga, Tadashi</creatorcontrib><title>Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab</title><title>Modern rheumatology</title><description>Abstract
We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude that the indications for tumor necrosis factor (TNF) inhibitors should be strictly decided and that a nationwide cohort study is necessary to assess the risk of cancer in patients with JIA exposed to biologics.</description><subject>Arthritis</subject><subject>Cancer</subject><subject>Medical treatment</subject><subject>Monoclonal antibodies</subject><subject>Rheumatology</subject><subject>Risk assessment</subject><subject>TNF inhibitors</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kM1OwzAQhC0EEqXwANwscQ7YcZzE4oTKr1SJC5wtN143rpI42E6hfXqCQiUunHYPMzs7H0KXlFwzSsRNoITmPCGUJoRznuyP0IxmTCRFTsTxYeeCn6KzEDaEMC5KMUPtPWyhcX0LXcTO4DX41nauVVgP3nZrHGvA0YOKB0XYhQitrRLXBYh4M2yhsw1gq63rVaxthZWPtbfRBvxpY41tZxr7ZVu1OkcnRjUBLn7nHL0_PrwtnpPl69PL4m6ZVLTgacIV4yQvhU51mSkQuVApg0pxnpaMlUoLYwhZgckMhypVWT4WMyzVnIJWOmNzdDXd7b37GCBEuXGD78ZISVlBipxlRTqq6KSqvAvBg5G9H7_0O0mJ_KEqJ6pypCp_qMr96LmdPGMp51tVg2piXSkPfyL-dX8Djs6BJw</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Takezaki, Shunichiro</creator><creator>Okura, Yuka</creator><creator>Ichikawa, Mizuho</creator><creator>Suzuki, Daisuke</creator><creator>Ohshima, Junjiro</creator><creator>Kaneda, Makoto</creator><creator>Cho, Yuko</creator><creator>Yamada, Masafumi</creator><creator>Kawamura, Nobuaki</creator><creator>Iguchi, Akihiro</creator><creator>Kobayashi, Ichiro</creator><creator>Ariga, Tadashi</creator><general>Informa Healthcare</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201208</creationdate><title>Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab</title><author>Takezaki, Shunichiro ; Okura, Yuka ; Ichikawa, Mizuho ; Suzuki, Daisuke ; Ohshima, Junjiro ; Kaneda, Makoto ; Cho, Yuko ; Yamada, Masafumi ; Kawamura, Nobuaki ; Iguchi, Akihiro ; Kobayashi, Ichiro ; Ariga, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1752-5a350689d2d84ae969a23eca5528338ad9ff00bef4f5ec2a46595f32d51edad43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Arthritis</topic><topic>Cancer</topic><topic>Medical treatment</topic><topic>Monoclonal antibodies</topic><topic>Rheumatology</topic><topic>Risk assessment</topic><topic>TNF inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takezaki, Shunichiro</creatorcontrib><creatorcontrib>Okura, Yuka</creatorcontrib><creatorcontrib>Ichikawa, Mizuho</creatorcontrib><creatorcontrib>Suzuki, Daisuke</creatorcontrib><creatorcontrib>Ohshima, Junjiro</creatorcontrib><creatorcontrib>Kaneda, Makoto</creatorcontrib><creatorcontrib>Cho, Yuko</creatorcontrib><creatorcontrib>Yamada, Masafumi</creatorcontrib><creatorcontrib>Kawamura, Nobuaki</creatorcontrib><creatorcontrib>Iguchi, Akihiro</creatorcontrib><creatorcontrib>Kobayashi, Ichiro</creatorcontrib><creatorcontrib>Ariga, Tadashi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takezaki, Shunichiro</au><au>Okura, Yuka</au><au>Ichikawa, Mizuho</au><au>Suzuki, Daisuke</au><au>Ohshima, Junjiro</au><au>Kaneda, Makoto</au><au>Cho, Yuko</au><au>Yamada, Masafumi</au><au>Kawamura, Nobuaki</au><au>Iguchi, Akihiro</au><au>Kobayashi, Ichiro</au><au>Ariga, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab</atitle><jtitle>Modern rheumatology</jtitle><date>2012-08</date><risdate>2012</risdate><volume>22</volume><issue>4</issue><spage>621</spage><epage>624</epage><pages>621-624</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>Abstract
We report a 19-year-old patient with systemic-onset juvenile idiopathic arthritis (JIA) who developed a mediastinal germinoma during treatment with infliximab. Although the cancer risk of infliximab is controversial, this agent may have accelerated the growth of the germinoma. We conclude that the indications for tumor necrosis factor (TNF) inhibitors should be strictly decided and that a nationwide cohort study is necessary to assess the risk of cancer in patients with JIA exposed to biologics.</abstract><cop>Tokyo</cop><pub>Informa Healthcare</pub><doi>10.3109/s10165-011-0555-z</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-7595 |
| ispartof | Modern rheumatology, 2012-08, Vol.22 (4), p.621-624 |
| issn | 1439-7595 1439-7609 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Arthritis Cancer Medical treatment Monoclonal antibodies Rheumatology Risk assessment TNF inhibitors |
| title | Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab |
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