One component? Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2
Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from aberrant connectivity. Multicomponent driven equilibrium single pulse observation of T1 and T2 is a time‐efficient multicompo...
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| Veröffentlicht in: | Magnetic resonance in medicine 2013-07, Vol.70 (1), p.147-154 |
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| creator | Deoni, Sean C. L. Matthews, Lucy Kolind, Shannon H. |
| description | Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from aberrant connectivity. Multicomponent driven equilibrium single pulse observation of T1 and T2 is a time‐efficient multicomponent relaxation analysis technique that provides estimates of the myelin water fraction, a surrogate measure of myelin volume. Unfortunately, multicomponent driven equilibrium single pulse observation of T1 and T2 relies on a two water‐pool model (myelin‐associated water and intra/extracellular water), which is inadequate within partial volume voxels, i.e., containing brain tissue and ventricle or meninges, resulting in myelin water fraction underestimation. To address this, a third, nonexchanging “free‐water” component was introduced to the multicomponent driven equilibrium single pulse observation of T1 and T2 model. Numerical simulations and experimental in vivo data show that the model to perform advantageously within partial volume regions while providing robust and reproducible results. It is concluded that this model is preferable for future studies and analysis. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mrm.24429 |
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Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Deoni, Sean C. L. ; Matthews, Lucy ; Kolind, Shannon H.</creator><creatorcontrib>Deoni, Sean C. L. ; Matthews, Lucy ; Kolind, Shannon H.</creatorcontrib><description>Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from aberrant connectivity. Multicomponent driven equilibrium single pulse observation of T1 and T2 is a time‐efficient multicomponent relaxation analysis technique that provides estimates of the myelin water fraction, a surrogate measure of myelin volume. Unfortunately, multicomponent driven equilibrium single pulse observation of T1 and T2 relies on a two water‐pool model (myelin‐associated water and intra/extracellular water), which is inadequate within partial volume voxels, i.e., containing brain tissue and ventricle or meninges, resulting in myelin water fraction underestimation. To address this, a third, nonexchanging “free‐water” component was introduced to the multicomponent driven equilibrium single pulse observation of T1 and T2 model. Numerical simulations and experimental in vivo data show that the model to perform advantageously within partial volume regions while providing robust and reproducible results. It is concluded that this model is preferable for future studies and analysis. 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L.</creatorcontrib><creatorcontrib>Matthews, Lucy</creatorcontrib><creatorcontrib>Kolind, Shannon H.</creatorcontrib><title>One component? Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from aberrant connectivity. Multicomponent driven equilibrium single pulse observation of T1 and T2 is a time‐efficient multicomponent relaxation analysis technique that provides estimates of the myelin water fraction, a surrogate measure of myelin volume. Unfortunately, multicomponent driven equilibrium single pulse observation of T1 and T2 relies on a two water‐pool model (myelin‐associated water and intra/extracellular water), which is inadequate within partial volume voxels, i.e., containing brain tissue and ventricle or meninges, resulting in myelin water fraction underestimation. To address this, a third, nonexchanging “free‐water” component was introduced to the multicomponent driven equilibrium single pulse observation of T1 and T2 model. Numerical simulations and experimental in vivo data show that the model to perform advantageously within partial volume regions while providing robust and reproducible results. It is concluded that this model is preferable for future studies and analysis. 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L.</creatorcontrib><creatorcontrib>Matthews, Lucy</creatorcontrib><creatorcontrib>Kolind, Shannon H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deoni, Sean C. L.</au><au>Matthews, Lucy</au><au>Kolind, Shannon H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One component? Two components? Three? 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| subjects | Adult Aged, 80 and over Body Water - cytology Brain - pathology Female human brain imaging Humans Image Interpretation, Computer-Assisted - methods Infant Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Molecular Imaging - methods myelin imaging Myelin Sheath - pathology myelin water fraction quantitative imaging Reproducibility of Results Sensitivity and Specificity Spinal Cord - pathology Tissue Distribution white matter imaging |
| title | One component? Two components? Three? The effect of including a nonexchanging "free" water component in multicomponent driven equilibrium single pulse observation of T1 and T2 |
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