Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RAR[Beta] and tumor regression

Toll-like receptor 3 (TLR3) is a key effector of the innate immune system against viruses. Activation of TLR3 exerts an antitumoral effect through a mechanism of action still poorly understood. Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (24), p.9812
Hauptverfasser:	Galli, Roberta, Paone, Alessio, Fabbri, Muller, Zanesi, Nicola, Calore, Federica, Cascione, Luciano, Acunzo, Mario, Stoppacciaro, Antonella, Tubaro, Andrea, Lovat, Francesca, Gasparini, Pierluigi, Fadda, Paolo, Alder, Hansjuerg, Volinia, Stefano, Filippini, Antonio, Ziparo, Elio, Riccioli, Anna, Croce, Carlo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Deoxyribonucleic acid DNA Immune system T cell receptors Tumors Viruses
Online-Zugang:	Volltext
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