Mitochondrial Dysfunction Induced by Honokiol
Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H + and K + ,...
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| Veröffentlicht in: | The Journal of membrane biology 2013-05, Vol.246 (5), p.375-381 |
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| creator | Dong, Jia-Xin Zhao, Guang-Yuan Yu, Qiu-Li-Yang Li, Ran Yuan, Lian Chen, Jing Liu, Yi |
| description | Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H
+
and K
+
, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling, decrease membrane potential and affect the respiration of mitochondria. Meanwhile, honokiol does not have a direct effect on the mitochondrial permeability transition pore. |
| doi_str_mv | 10.1007/s00232-013-9543-x |
| format | Article |
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+
and K
+
, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling, decrease membrane potential and affect the respiration of mitochondria. Meanwhile, honokiol does not have a direct effect on the mitochondrial permeability transition pore.</description><identifier>ISSN: 0022-2631</identifier><identifier>EISSN: 1432-1424</identifier><identifier>DOI: 10.1007/s00232-013-9543-x</identifier><identifier>PMID: 23595822</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - pharmacokinetics ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biphenyl Compounds - pharmacokinetics ; Biphenyl Compounds - pharmacology ; Cancer ; Cell Line, Tumor ; Cellular biology ; Human Physiology ; Life Sciences ; Lignans - pharmacokinetics ; Lignans - pharmacology ; Membrane Potential, Mitochondrial - drug effects ; Membranes ; Mitochondria ; Mitochondria, Liver - metabolism ; Mitochondria, Liver - pathology ; Mitochondrial Membranes - metabolism ; Oxygen Consumption - drug effects ; Permeability - drug effects ; Rats ; Rats, Wistar</subject><ispartof>The Journal of membrane biology, 2013-05, Vol.246 (5), p.375-381</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-234c054dd0fa2e81b3a2c96114ebaa5eabf87f51545383eb04b68d309cd8f5f23</citedby><cites>FETCH-LOGICAL-c372t-234c054dd0fa2e81b3a2c96114ebaa5eabf87f51545383eb04b68d309cd8f5f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00232-013-9543-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00232-013-9543-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23595822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Jia-Xin</creatorcontrib><creatorcontrib>Zhao, Guang-Yuan</creatorcontrib><creatorcontrib>Yu, Qiu-Li-Yang</creatorcontrib><creatorcontrib>Li, Ran</creatorcontrib><creatorcontrib>Yuan, Lian</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><title>Mitochondrial Dysfunction Induced by Honokiol</title><title>The Journal of membrane biology</title><addtitle>J Membrane Biol</addtitle><addtitle>J Membr Biol</addtitle><description>Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H
+
and K
+
, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling, decrease membrane potential and affect the respiration of mitochondria. Meanwhile, honokiol does not have a direct effect on the mitochondrial permeability transition pore.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacokinetics</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biphenyl Compounds - pharmacokinetics</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cellular biology</subject><subject>Human Physiology</subject><subject>Life Sciences</subject><subject>Lignans - pharmacokinetics</subject><subject>Lignans - pharmacology</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Membranes</subject><subject>Mitochondria</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Mitochondria, Liver - pathology</subject><subject>Mitochondrial Membranes - metabolism</subject><subject>Oxygen Consumption - drug effects</subject><subject>Permeability - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0022-2631</issn><issn>1432-1424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0MuI7mOplZSr20UHGj65DJRae2SU1moH17U6aKG1cHzn-DD4BLjG4wQuI2IUQogQhTWHNG4fYIjDHLH8wIOwbjLBNISopH4CylJUJYiJKdghGhvOYVIWMAn9su6I_gTWzVqrjfJdd73bXBF3Nvem1N0eyKWfDhsw2rc3Di1CrZi8OdgLfHh9fpDC5enubTuwXUVJAOEso04swY5BSxFW6oIrouMWa2UYpb1bhKOI4547SitkGsKStDUa1N5bgjdAKuh95NDF-9TZ1chj76PCkx5QJzJEqRXXhw6RhSitbJTWzXKu4kRnIPSA6AZAYk94DkNmeuDs19s7bmN_FDJBvIYEhZ8u82_pn-t_UbXSxv6g</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Dong, Jia-Xin</creator><creator>Zhao, Guang-Yuan</creator><creator>Yu, Qiu-Li-Yang</creator><creator>Li, Ran</creator><creator>Yuan, Lian</creator><creator>Chen, Jing</creator><creator>Liu, Yi</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130501</creationdate><title>Mitochondrial Dysfunction Induced by Honokiol</title><author>Dong, Jia-Xin ; Zhao, Guang-Yuan ; Yu, Qiu-Li-Yang ; Li, Ran ; Yuan, Lian ; Chen, Jing ; Liu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-234c054dd0fa2e81b3a2c96114ebaa5eabf87f51545383eb04b68d309cd8f5f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacokinetics</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biphenyl Compounds - pharmacokinetics</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cellular biology</topic><topic>Human Physiology</topic><topic>Life Sciences</topic><topic>Lignans - pharmacokinetics</topic><topic>Lignans - pharmacology</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Membranes</topic><topic>Mitochondria</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Mitochondria, Liver - pathology</topic><topic>Mitochondrial Membranes - metabolism</topic><topic>Oxygen Consumption - drug effects</topic><topic>Permeability - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Jia-Xin</creatorcontrib><creatorcontrib>Zhao, Guang-Yuan</creatorcontrib><creatorcontrib>Yu, Qiu-Li-Yang</creatorcontrib><creatorcontrib>Li, Ran</creatorcontrib><creatorcontrib>Yuan, Lian</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The Journal of membrane biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Jia-Xin</au><au>Zhao, Guang-Yuan</au><au>Yu, Qiu-Li-Yang</au><au>Li, Ran</au><au>Yuan, Lian</au><au>Chen, Jing</au><au>Liu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial Dysfunction Induced by Honokiol</atitle><jtitle>The Journal of membrane biology</jtitle><stitle>J Membrane Biol</stitle><addtitle>J Membr Biol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>246</volume><issue>5</issue><spage>375</spage><epage>381</epage><pages>375-381</pages><issn>0022-2631</issn><eissn>1432-1424</eissn><abstract>Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H
+
and K
+
, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling, decrease membrane potential and affect the respiration of mitochondria. Meanwhile, honokiol does not have a direct effect on the mitochondrial permeability transition pore.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23595822</pmid><doi>10.1007/s00232-013-9543-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Biochemistry Biomedical and Life Sciences Biphenyl Compounds - pharmacokinetics Biphenyl Compounds - pharmacology Cancer Cell Line, Tumor Cellular biology Human Physiology Life Sciences Lignans - pharmacokinetics Lignans - pharmacology Membrane Potential, Mitochondrial - drug effects Membranes Mitochondria Mitochondria, Liver - metabolism Mitochondria, Liver - pathology Mitochondrial Membranes - metabolism Oxygen Consumption - drug effects Permeability - drug effects Rats Rats, Wistar |
| title | Mitochondrial Dysfunction Induced by Honokiol |
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