Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress

A prolonged or excessive adrenergic activation leads to myocyte loss and heart dysfunction; however, how it contributes to heart failure remains poorly defined. Here we show that isoproterenol (ISO) induced aberrant endoplasmic reticulum (ER) stress and apoptotic cell death, which was inhibited by a...

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Veröffentlicht in:	Apoptosis (London) 2013-07, Vol.18 (7), p.800-810
Hauptverfasser:	Zhuo, Xiao-Zhen, Wu, Yue, Ni, Ya-Juan, Liu, Jun-Hui, Gong, Min, Wang, Xue-Hui, Wei, Feng, Wang, Ting-Zhong, Yuan, Zuyi, Ma, Ai-Qun, Song, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - deficiency AMP-Activated Protein Kinases - genetics Animals Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects Gene Expression Regulation Heart Failure - chemically induced Heart Failure - enzymology Heart Failure - pathology Heart Failure - prevention & control Inactivation Isoproterenol - adverse effects Male Metformin - pharmacology Mice Mice, Knockout Myocardium - enzymology Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Natriuretic Peptide, Brain - metabolism Oncology Original Paper Phosphorylation Pyrazoles - pharmacology Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Signal Transduction Stress Virology
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