Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats
This study was designed to investigate histological changes in skin tissue accompanying immobilization-induced hypersensitivity. Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4...
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| Veröffentlicht in: | Physiological research 2012-01, Vol.61 (6), p.643-647 |
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| creator | Nakano, J Sekino, Y Hamaue, Y Sakamoto, J Yoshimura, T Origuchi, T Okita, M |
| description | This study was designed to investigate histological changes in skin tissue accompanying immobilization-induced hypersensitivity. Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4 weeks of ankle joint immobilization by plaster casts. Induction of mechanical hypersensitivity was confirmed after 2 and 4 weeks of joint immobilization. Epidermal thinning and increase in peripheral nerve profiles were observed in skin tissues in immobilized rats. The time course of epidermal thinning and increase in peripheral nerve profiles were similar closely to that of hypersensitivity, with significant differences between the immobilized and control rats after 2 weeks of immobilization, which became even more remarkable at 4 weeks of immobilization. These findings suggest that joint immobilization by cast induces epidermal thinning and increases peripheral nerve profiles in the upper dermis and that these changes might be partly responsible for immobilization-induced hypersensitivity. |
| doi_str_mv | 10.33549/physiolres.932362 |
| format | Article |
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Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4 weeks of ankle joint immobilization by plaster casts. Induction of mechanical hypersensitivity was confirmed after 2 and 4 weeks of joint immobilization. Epidermal thinning and increase in peripheral nerve profiles were observed in skin tissues in immobilized rats. The time course of epidermal thinning and increase in peripheral nerve profiles were similar closely to that of hypersensitivity, with significant differences between the immobilized and control rats after 2 weeks of immobilization, which became even more remarkable at 4 weeks of immobilization. These findings suggest that joint immobilization by cast induces epidermal thinning and increases peripheral nerve profiles in the upper dermis and that these changes might be partly responsible for immobilization-induced hypersensitivity.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.932362</identifier><identifier>PMID: 23098655</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Animals ; Behavior ; Diabetic neuropathy ; Epidermis - innervation ; Epidermis - pathology ; Hindlimb ; Injuries ; Male ; Peripheral Nerves - physiology ; Rats ; Rats, Wistar ; Restraint, Physical ; Rodents ; Stress, Mechanical ; Studies</subject><ispartof>Physiological research, 2012-01, Vol.61 (6), p.643-647</ispartof><rights>Copyright Institute of Physiology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-9a4f5ee39202a5b64b28991d0f7daa239607033b0a9b6a41b96be9e46cd403d73</citedby><cites>FETCH-LOGICAL-c338t-9a4f5ee39202a5b64b28991d0f7daa239607033b0a9b6a41b96be9e46cd403d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23098655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakano, J</creatorcontrib><creatorcontrib>Sekino, Y</creatorcontrib><creatorcontrib>Hamaue, Y</creatorcontrib><creatorcontrib>Sakamoto, J</creatorcontrib><creatorcontrib>Yoshimura, T</creatorcontrib><creatorcontrib>Origuchi, T</creatorcontrib><creatorcontrib>Okita, M</creatorcontrib><title>Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>This study was designed to investigate histological changes in skin tissue accompanying immobilization-induced hypersensitivity. Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4 weeks of ankle joint immobilization by plaster casts. Induction of mechanical hypersensitivity was confirmed after 2 and 4 weeks of joint immobilization. Epidermal thinning and increase in peripheral nerve profiles were observed in skin tissues in immobilized rats. The time course of epidermal thinning and increase in peripheral nerve profiles were similar closely to that of hypersensitivity, with significant differences between the immobilized and control rats after 2 weeks of immobilization, which became even more remarkable at 4 weeks of immobilization. These findings suggest that joint immobilization by cast induces epidermal thinning and increases peripheral nerve profiles in the upper dermis and that these changes might be partly responsible for immobilization-induced hypersensitivity.</description><subject>Animals</subject><subject>Behavior</subject><subject>Diabetic neuropathy</subject><subject>Epidermis - innervation</subject><subject>Epidermis - pathology</subject><subject>Hindlimb</subject><subject>Injuries</subject><subject>Male</subject><subject>Peripheral Nerves - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical</subject><subject>Rodents</subject><subject>Stress, Mechanical</subject><subject>Studies</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFkMtOwzAQRS0EoqXwAyyQJbYEHE8e9hJVvCQkNrCO7GRCBpoHtgsqC76d0BZYjTQ6917pMHYci3OANNEXQ7Py1C8c-nMNEjK5w6axEjLSOoddNhUqk5FKhJqwA-9fhJC5yGGfTSQIrbI0nbKveWO6Z_ScOt5QV_HBfHAcqELXmgUPDZWvHXp_xgd0NDToxm-H7h15RT44sstAfcfNGG2xHMuoHAmPnadA7xRW3NQBHae27S0t6NOs-XHOmeAP2V5tFh6PtnfGnq6vHue30f3Dzd388j4qAVSItEnqFBG0FNKkNkusVFrHlajzyhgJOhO5ALDCaJuZJLY6s6gxycoqEVDlMGOnm97B9W9L9KF46ZeuGyeLGBKlIAf1Q8kNVbree4d1MThqjVsVsSjWyot_5cVG-Rg62VYvbYvVX-TXMXwDObGCpw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Nakano, J</creator><creator>Sekino, Y</creator><creator>Hamaue, Y</creator><creator>Sakamoto, J</creator><creator>Yoshimura, T</creator><creator>Origuchi, T</creator><creator>Okita, M</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20120101</creationdate><title>Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats</title><author>Nakano, J ; Sekino, Y ; Hamaue, Y ; Sakamoto, J ; Yoshimura, T ; Origuchi, T ; Okita, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-9a4f5ee39202a5b64b28991d0f7daa239607033b0a9b6a41b96be9e46cd403d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Diabetic neuropathy</topic><topic>Epidermis - innervation</topic><topic>Epidermis - pathology</topic><topic>Hindlimb</topic><topic>Injuries</topic><topic>Male</topic><topic>Peripheral Nerves - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Restraint, Physical</topic><topic>Rodents</topic><topic>Stress, Mechanical</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakano, J</creatorcontrib><creatorcontrib>Sekino, Y</creatorcontrib><creatorcontrib>Hamaue, Y</creatorcontrib><creatorcontrib>Sakamoto, J</creatorcontrib><creatorcontrib>Yoshimura, T</creatorcontrib><creatorcontrib>Origuchi, T</creatorcontrib><creatorcontrib>Okita, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakano, J</au><au>Sekino, Y</au><au>Hamaue, Y</au><au>Sakamoto, J</au><au>Yoshimura, T</au><au>Origuchi, T</au><au>Okita, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>61</volume><issue>6</issue><spage>643</spage><epage>647</epage><pages>643-647</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>This study was designed to investigate histological changes in skin tissue accompanying immobilization-induced hypersensitivity. Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4 weeks of ankle joint immobilization by plaster casts. Induction of mechanical hypersensitivity was confirmed after 2 and 4 weeks of joint immobilization. Epidermal thinning and increase in peripheral nerve profiles were observed in skin tissues in immobilized rats. The time course of epidermal thinning and increase in peripheral nerve profiles were similar closely to that of hypersensitivity, with significant differences between the immobilized and control rats after 2 weeks of immobilization, which became even more remarkable at 4 weeks of immobilization. These findings suggest that joint immobilization by cast induces epidermal thinning and increases peripheral nerve profiles in the upper dermis and that these changes might be partly responsible for immobilization-induced hypersensitivity.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>23098655</pmid><doi>10.33549/physiolres.932362</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Behavior Diabetic neuropathy Epidermis - innervation Epidermis - pathology Hindlimb Injuries Male Peripheral Nerves - physiology Rats Rats, Wistar Restraint, Physical Rodents Stress, Mechanical Studies |
| title | Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats |
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