Crosstalk between the proteasome system an autophagy in the clearance of a-synuclein

A growing body of evidence suggests that α-synuclein accumulation may play an important role in the pathogenesis of Parkinson＇s disease. The aim of this study was to investigate the roles of the proteasome and autophagy pathways in the clearance of wild-type and mutant α-synuclein in PC12 cells. Met...

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Veröffentlicht in:	Acta pharmacologica Sinica 2013-05, Vol.34 (5), p.674-680
Hauptverfasser:	Yang, Fang, Yang, Ya-ping, Mao, Cheng-jie, Liu, Ling, Zheng, Hui-fen, Hu, Li-fang, Liu, Chun-feng
Format:	Artikel
Sprache:	eng
Schlagworte:	PC12细胞 α-突触核蛋白 串扰 自噬 蛋白酶体抑制剂 蛋白酶活性 间隙 雷帕霉素
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