Spectroscopic Study of DNA Hydrolysis, DNA Intercalative, and Electrostatic Interaction Activity Exerted by Drug Based Coordination Compounds

Our work emphasized on synthesizing and characterizing neutral mononuclear copper(II) complexes with second generation fluoroquinolone drug ciprofloxacin (CFL) and some bipyridine derivatives (An) of type [Cu(CFL)(An)Cl]·2H2O. The DNA binding free energies were evaluated by studying the effect of sa...

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Veröffentlicht in:	Zeitschrift für anorganische und allgemeine Chemie (1950) 2012-01, Vol.638 (1), p.152-162
Hauptverfasser:	Patel, Mohan N., Bhatt, Bhupesh S., Dosi, Promise A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bactericidal activity Copper DNA cleavage DNA degradation Hydrolytic cleavage
Online-Zugang:	Volltext
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