MiR-17-3p Inhibits Angiogenesis by Downregulating Flk-1 in the Cell Growth Signal Pathway

MicroRNAs (miRs) are endogenously expressed small noncoding RNAs that regulate gene expression at the posttranscriptional level. Previous works indicated that the miR-17-92 cluster could regulate endothelial cell (EC) functions involved in angiogenesis. miR-17-3p, a component of the miR-17-92 cluste...

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Veröffentlicht in:	Journal of vascular research 2013-01, Vol.50 (2), p.157-166
Hauptverfasser:	Yin, Runting, Wang, Rubing, Guo, Le, Zhang, Wei, Lu, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Cycle - genetics Cell Cycle - physiology Cell Movement - genetics Cell Movement - physiology Down-Regulation Endothelial Cells - physiology Gene Expression Regulation Genes, Reporter HEK293 Cells Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans MicroRNAs - genetics MicroRNAs - physiology Molecular Sequence Data Neovascularization, Pathologic - genetics Neovascularization, Pathologic - physiopathology Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Primary Cell Culture Research Paper RNA - physiology Signal Transduction - physiology Transfection Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - biosynthesis Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - physiology
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