A cell-cell communication signal integrates quorum sensing and stress response
IQS is a Pseudomonas aeruginosa quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy. Pseudomonas aeruginosa uses a hierarchical quorum sensing (QS) network consisting of las , pqs and rhl regulatory elements to coordinate the express...
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| Veröffentlicht in: | Nature chemical biology 2013-05, Vol.9 (5), p.339-343 |
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| creator | Lee, Jasmine Wu, Jien Deng, Yinyue Wang, Jing Wang, Chao Wang, Jianhe Chang, Changqing Dong, Yihu Williams, Paul Zhang, Lian-Hui |
| description | IQS is a
Pseudomonas aeruginosa
quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy.
Pseudomonas aeruginosa
uses a hierarchical quorum sensing (QS) network consisting of
las
,
pqs
and
rhl
regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central
las
system. This motivated us to search for a mechanism that may functionally substitute
las
. Here we report identification of a new QS signal, IQS. Disruption of IQS biosynthesis paralyzes the
pqs
and
rhl
QS systems and attenuates bacterial virulence. Production of IQS is tightly controlled by
las
under normal culture conditions but is also activated by phosphate limitation, a common stressor that bacteria encounter during infections. Thus, these results have established an integrated QS system that connects the central
las
system and phosphate-stress response mechanism to the downstream
pqs
and
rhl
regulatory systems. Our discovery highlights the complexity of QS signaling systems and extends the gamut of QS and stress-response mechanisms. |
| doi_str_mv | 10.1038/nchembio.1225 |
| format | Article |
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Pseudomonas aeruginosa
quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy.
Pseudomonas aeruginosa
uses a hierarchical quorum sensing (QS) network consisting of
las
,
pqs
and
rhl
regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central
las
system. This motivated us to search for a mechanism that may functionally substitute
las
. Here we report identification of a new QS signal, IQS. Disruption of IQS biosynthesis paralyzes the
pqs
and
rhl
QS systems and attenuates bacterial virulence. Production of IQS is tightly controlled by
las
under normal culture conditions but is also activated by phosphate limitation, a common stressor that bacteria encounter during infections. Thus, these results have established an integrated QS system that connects the central
las
system and phosphate-stress response mechanism to the downstream
pqs
and
rhl
regulatory systems. Our discovery highlights the complexity of QS signaling systems and extends the gamut of QS and stress-response mechanisms.</description><identifier>ISSN: 1552-4450</identifier><identifier>EISSN: 1552-4469</identifier><identifier>DOI: 10.1038/nchembio.1225</identifier><identifier>PMID: 23542643</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/326/41 ; 631/80/86 ; 631/92/604 ; 631/92/613 ; Bacteria ; Bacterial infections ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biochemical Engineering ; Biochemistry ; Bioorganic Chemistry ; Biosynthesis ; Cell Biology ; Cellular biology ; Chemistry ; Chemistry/Food Science ; Gene expression ; Immunology ; Molecular biology ; Mutation ; Pseudomonas aeruginosa - cytology ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - metabolism ; Quorum Sensing ; Signal Transduction ; Stress, Physiological</subject><ispartof>Nature chemical biology, 2013-05, Vol.9 (5), p.339-343</ispartof><rights>Springer Nature America, Inc. 2013</rights><rights>Copyright Nature Publishing Group May 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p175t-b771f6a841b9536992f0c005c2333a637eefa6ac26c8c363d312fcad69cc56323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nchembio.1225$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nchembio.1225$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23542643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jasmine</creatorcontrib><creatorcontrib>Wu, Jien</creatorcontrib><creatorcontrib>Deng, Yinyue</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Wang, Jianhe</creatorcontrib><creatorcontrib>Chang, Changqing</creatorcontrib><creatorcontrib>Dong, Yihu</creatorcontrib><creatorcontrib>Williams, Paul</creatorcontrib><creatorcontrib>Zhang, Lian-Hui</creatorcontrib><title>A cell-cell communication signal integrates quorum sensing and stress response</title><title>Nature chemical biology</title><addtitle>Nat Chem Biol</addtitle><addtitle>Nat Chem Biol</addtitle><description>IQS is a
Pseudomonas aeruginosa
quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy.
Pseudomonas aeruginosa
uses a hierarchical quorum sensing (QS) network consisting of
las
,
pqs
and
rhl
regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central
las
system. This motivated us to search for a mechanism that may functionally substitute
las
. Here we report identification of a new QS signal, IQS. Disruption of IQS biosynthesis paralyzes the
pqs
and
rhl
QS systems and attenuates bacterial virulence. Production of IQS is tightly controlled by
las
under normal culture conditions but is also activated by phosphate limitation, a common stressor that bacteria encounter during infections. Thus, these results have established an integrated QS system that connects the central
las
system and phosphate-stress response mechanism to the downstream
pqs
and
rhl
regulatory systems. 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Biol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>9</volume><issue>5</issue><spage>339</spage><epage>343</epage><pages>339-343</pages><issn>1552-4450</issn><eissn>1552-4469</eissn><abstract>IQS is a
Pseudomonas aeruginosa
quorum sensing molecule that functions during phosphate limitation and lies near the top of the QS signaling hierarchy.
Pseudomonas aeruginosa
uses a hierarchical quorum sensing (QS) network consisting of
las
,
pqs
and
rhl
regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central
las
system. This motivated us to search for a mechanism that may functionally substitute
las
. Here we report identification of a new QS signal, IQS. Disruption of IQS biosynthesis paralyzes the
pqs
and
rhl
QS systems and attenuates bacterial virulence. Production of IQS is tightly controlled by
las
under normal culture conditions but is also activated by phosphate limitation, a common stressor that bacteria encounter during infections. Thus, these results have established an integrated QS system that connects the central
las
system and phosphate-stress response mechanism to the downstream
pqs
and
rhl
regulatory systems. Our discovery highlights the complexity of QS signaling systems and extends the gamut of QS and stress-response mechanisms.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23542643</pmid><doi>10.1038/nchembio.1225</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature chemical biology, 2013-05, Vol.9 (5), p.339-343 |
| issn | 1552-4450 1552-4469 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | 631/326/41 631/80/86 631/92/604 631/92/613 Bacteria Bacterial infections Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Cell Biology Cellular biology Chemistry Chemistry/Food Science Gene expression Immunology Molecular biology Mutation Pseudomonas aeruginosa - cytology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Quorum Sensing Signal Transduction Stress, Physiological |
| title | A cell-cell communication signal integrates quorum sensing and stress response |
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