Coupled solutions of one- and two-compartment pharmacokinetic models with first-order absorption

This work emphasizes the importance of the fact, that plasma concentration profiles of one- and two-compartment linear pharmacokinetic (PK) models with first-order absorption introduce an uncertainty in data interpretation. PK-curve fitting results in a pair of valid solutions (coupled solutions), f...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2013-04, Vol.40 (2), p.229-241
Hauptverfasser:	Asmanova, N., Koloskov, G., Ilin, A. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Area Under Curve Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Models, Biological Original Paper Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacology/Toxicology Pharmacy Solutions - metabolism Veterinary Medicine/Veterinary Science
Online-Zugang:	Volltext
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