Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates
Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were a...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2013-05, Vol.102 (5), p.1650-1660 |
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| creator | Wehrung, Daniel Sun, Shuangyi Chamsaz, Elaheh A. Joy, Abraham Oyewumi, Moses O. |
| description | Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p > 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials. |
| doi_str_mv | 10.1002/jps.23510 |
| format | Article |
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Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p > 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.23510</identifier><identifier>PMID: 23529816</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Hoboken: Elsevier Inc</publisher><subject>Alanine Transaminase - blood ; alkoxylphenacyl ; Animals ; biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - metabolism ; Biocompatible Materials - toxicity ; Cell Line ; Creatine - blood ; Cytokines - analysis ; Erythrocytes - drug effects ; Hemolysis - drug effects ; implants ; Kidney - drug effects ; Kidney - pathology ; Light ; Liver - drug effects ; Liver - pathology ; Macrophages - cytology ; Macrophages - drug effects ; Mice ; Mice, Inbred BALB C ; photoresponsive ; polycarbonates ; Polycarboxylate Cement - chemistry ; Polycarboxylate Cement - metabolism ; Polycarboxylate Cement - toxicity ; Rats ; Rats, Sprague-Dawley ; toxicity</subject><ispartof>Journal of pharmaceutical sciences, 2013-05, Vol.102 (5), p.1650-1660</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3970-c85686c7a414c7814c5dc6228f6df0cabaf7c0543d449d438a53a42e7f4f1afd3</citedby><cites>FETCH-LOGICAL-c3970-c85686c7a414c7814c5dc6228f6df0cabaf7c0543d449d438a53a42e7f4f1afd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.23510$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.23510$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23529816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wehrung, Daniel</creatorcontrib><creatorcontrib>Sun, Shuangyi</creatorcontrib><creatorcontrib>Chamsaz, Elaheh A.</creatorcontrib><creatorcontrib>Joy, Abraham</creatorcontrib><creatorcontrib>Oyewumi, Moses O.</creatorcontrib><title>Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates</title><title>Journal of pharmaceutical sciences</title><addtitle>J Pharm Sci</addtitle><description>Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p > 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.</description><subject>Alanine Transaminase - blood</subject><subject>alkoxylphenacyl</subject><subject>Animals</subject><subject>biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - metabolism</subject><subject>Biocompatible Materials - toxicity</subject><subject>Cell Line</subject><subject>Creatine - blood</subject><subject>Cytokines - analysis</subject><subject>Erythrocytes - drug effects</subject><subject>Hemolysis - drug effects</subject><subject>implants</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Light</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>photoresponsive</subject><subject>polycarbonates</subject><subject>Polycarboxylate Cement - chemistry</subject><subject>Polycarboxylate Cement - metabolism</subject><subject>Polycarboxylate Cement - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>toxicity</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OGzEUha2qqKTAoi9QWeqqiwH_zkyWEFEKQhCJn63l2NfCqTOe2pPAvH1NE1i1m2tdnc_H1ofQF0qOKSHsZNnnY8YlJR_QhEpGqprQ5iOalIxVXIrpPvqc85IQUhMpP6H9ArNpS-sJ6s98NHHV68EvfPDDiHVn8WWHH_0m4vsYIOldEB3W-Aae8SzonF_X-VMcYoLcxy77DeDT8Cu-jKF_gk6bMVRnOoPF8xhGo9MidnqAfIj2nA4ZjnbnAXr4cX4_-1ld315czk6vK8OnDalMK-u2No0WVJimLUNaUzPWuto6YvRCu8YQKbgVYmoFb7XkWjBonHBUO8sP0Ldtb5_i7zXkQS3jOnXlSUU5k41gvKGF-r6lTIo5J3CqT36l06goUa9uVXGr_rot7Ndd43qxAvtOvskswMkWePYBxv83qav53Vsl396AYmLjIalsPHQGrE9gBmWj_8dH_gC11JYg</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Wehrung, Daniel</creator><creator>Sun, Shuangyi</creator><creator>Chamsaz, Elaheh A.</creator><creator>Joy, Abraham</creator><creator>Oyewumi, Moses O.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201305</creationdate><title>Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates</title><author>Wehrung, Daniel ; Sun, Shuangyi ; Chamsaz, Elaheh A. ; Joy, Abraham ; Oyewumi, Moses O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3970-c85686c7a414c7814c5dc6228f6df0cabaf7c0543d449d438a53a42e7f4f1afd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alanine Transaminase - blood</topic><topic>alkoxylphenacyl</topic><topic>Animals</topic><topic>biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - metabolism</topic><topic>Biocompatible Materials - toxicity</topic><topic>Cell Line</topic><topic>Creatine - blood</topic><topic>Cytokines - analysis</topic><topic>Erythrocytes - drug effects</topic><topic>Hemolysis - drug effects</topic><topic>implants</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Light</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>photoresponsive</topic><topic>polycarbonates</topic><topic>Polycarboxylate Cement - chemistry</topic><topic>Polycarboxylate Cement - metabolism</topic><topic>Polycarboxylate Cement - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wehrung, Daniel</creatorcontrib><creatorcontrib>Sun, Shuangyi</creatorcontrib><creatorcontrib>Chamsaz, Elaheh A.</creatorcontrib><creatorcontrib>Joy, Abraham</creatorcontrib><creatorcontrib>Oyewumi, Moses O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wehrung, Daniel</au><au>Sun, Shuangyi</au><au>Chamsaz, Elaheh A.</au><au>Joy, Abraham</au><au>Oyewumi, Moses O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J Pharm Sci</addtitle><date>2013-05</date><risdate>2013</risdate><volume>102</volume><issue>5</issue><spage>1650</spage><epage>1660</epage><pages>1650-1660</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p > 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. 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| subjects | Alanine Transaminase - blood alkoxylphenacyl Animals biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biocompatible Materials - toxicity Cell Line Creatine - blood Cytokines - analysis Erythrocytes - drug effects Hemolysis - drug effects implants Kidney - drug effects Kidney - pathology Light Liver - drug effects Liver - pathology Macrophages - cytology Macrophages - drug effects Mice Mice, Inbred BALB C photoresponsive polycarbonates Polycarboxylate Cement - chemistry Polycarboxylate Cement - metabolism Polycarboxylate Cement - toxicity Rats Rats, Sprague-Dawley toxicity |
| title | Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates |
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