Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues. Muscle enzyme MG53 as drug target This paper reports the surprising finding that dysregulation of the muscle-specific E3 ligase mitsugumin (M...

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Veröffentlicht in:	Nature (London) 2013-02, Vol.494 (7437), p.375-379
Hauptverfasser:	Song, Ruisheng, Peng, Wei, Zhang, Yan, Lv, Fengxiang, Wu, Hong-Kun, Guo, Jiaojiao, Cao, Yongxing, Pi, Yanbin, Zhang, Xin, Jin, Li, Zhang, Mao, Jiang, Peng, Liu, Fenghua, Meng, Shaoshuai, Zhang, Xiuqin, Jiang, Ping, Cao, Chun-Mei, Xiao, Rui-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/1642/2037 Animals Carrier Proteins - genetics Carrier Proteins - metabolism Diabetes Diabetes Mellitus, Type 2 Diet Diet, High-Fat Dyslipidemias - metabolism Gene Deletion Glucose Humanities and Social Sciences Hypertension Hypertension - metabolism Insulin Insulin - metabolism Insulin Receptor Substrate Proteins - metabolism Insulin resistance Insulin Resistance - genetics Insulin Resistance - physiology letter Ligases Male Metabolic diseases Metabolic disorders Metabolic Syndrome - enzymology Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Metabolic Syndrome - prevention & control Mice multidisciplinary Muscular system Obesity Obesity - chemically induced Obesity - metabolism Physiological aspects Proteins Rats Rats, Inbred SHR Rats, Inbred WKY Receptor, Insulin - metabolism Rodents Science Signal Transduction Type 2 diabetes Ubiquitin Ubiquitin-Protein Ligases - metabolism Ubiquitination
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