Chemistry and toxicology of smokeless tobacco
In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicab...
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| Veröffentlicht in: | Indian journal of cancer 2012-10, Vol.49 (4), p.364-372 |
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| container_title | Indian journal of cancer |
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| creator | Bhisey, R |
| description | In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases including cancer, especially oral cancer, which is the leading cancer among men and the third most common cancer among women in India. This article highlights the toxicity, mutagenecity and carcinogenic effects of hazardous chemicals present in smokeless tobacco products. This endeavor was based on the extensive review of literature from various sources. The SLT products have influence on cellular metabolism, ability to cause DNA damage, and cancer in experimental animals. It is, therefore, essential to consider the collective role of chemical constituents of SLT products in the causation of adverse effect on human health. |
| doi_str_mv | 10.4103/0019-509X.107735 |
| format | Article |
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Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases including cancer, especially oral cancer, which is the leading cancer among men and the third most common cancer among women in India. This article highlights the toxicity, mutagenecity and carcinogenic effects of hazardous chemicals present in smokeless tobacco products. This endeavor was based on the extensive review of literature from various sources. The SLT products have influence on cellular metabolism, ability to cause DNA damage, and cancer in experimental animals. It is, therefore, essential to consider the collective role of chemical constituents of SLT products in the causation of adverse effect on human health.</description><subject>Animals</subject><subject>Arecaceae</subject><subject>Carcinogens</subject><subject>Carcinogens - toxicity</subject><subject>Chemistry</subject><subject>Cocarcinogens</subject><subject>Collagen</subject><subject>Copper</subject><subject>Descriptive labeling</subject><subject>DNA Damage</subject><subject>DNA repair</subject><subject>Dust</subject><subject>Factories</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>India</subject><subject>Ingredients</subject><subject>Magnesium</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - chemically induced</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Mouth Neoplasms - prevention & control</subject><subject>Nicotine</subject><subject>Oral cancer</subject><subject>Skin</subject><subject>Smokeless tobacco</subject><subject>Smoking - epidemiology</subject><subject>Smoking Prevention</subject><subject>Social aspects</subject><subject>Teeth</subject><subject>Tobacco Use Disorder - epidemiology</subject><subject>Tobacco Use Disorder - prevention & control</subject><subject>Tobacco, Smokeless - toxicity</subject><subject>Trace elements</subject><issn>0019-509X</issn><issn>1998-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtLAzEUhYMotlb3rqQguEtNJplHllp8QcGNgruQySTttJlJTWao_femTFtaKHcRuPnOfR0AbjEaUYzII0KYwRixnxFGaUriM9DHjGWQpik9B_39dw9ceT9HKCIRzS5BLyKURhShPoDjmapK37j1UNTFsLF_pbTGTtdDq4e-sgtllPchnwsp7TW40MJ4dbN9B-D79eVr_A4nn28f46cJlHHCHIzySOu4EJRkeQgWJZmmOi9QQVKFpaaFyKjGNIyTFGEMhKVQTCcUa52jnJEBuO_qLp39bZVv-Ny2rg4tOSZh-JTGQbynpsIoXtbaNk7IsI3kT2FRjKOMpYGCJ6ipqpUTxtZKlyF9xI9O8CGKcCh5UvBwIJgpYZqZt6ZtSlv7YxB1oHTWe6c0X7qyEm7NMeIbP_nGML4xjHd-Bsnd9hBtXqliL9gZGIDnDlhZ0yjnF6ZdKccDu6jt6qgwPCjMSUL5znryD9ArrEs</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Bhisey, R</creator><general>Medknow Publications</general><general>Medknow Publications and Media Pvt. 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| fulltext | fulltext |
| identifier | ISSN: 0019-509X |
| ispartof | Indian journal of cancer, 2012-10, Vol.49 (4), p.364-372 |
| issn | 0019-509X 1998-4774 |
| language | eng |
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| source | MEDLINE; Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Animals Arecaceae Carcinogens Carcinogens - toxicity Chemistry Cocarcinogens Collagen Copper Descriptive labeling DNA Damage DNA repair Dust Factories Female Genotype & phenotype Health aspects Health risk assessment Humans India Ingredients Magnesium Male Models, Animal Mouth Mucosa - metabolism Mouth Mucosa - pathology Mouth Neoplasms - chemically induced Mouth Neoplasms - epidemiology Mouth Neoplasms - prevention & control Nicotine Oral cancer Skin Smokeless tobacco Smoking - epidemiology Smoking Prevention Social aspects Teeth Tobacco Use Disorder - epidemiology Tobacco Use Disorder - prevention & control Tobacco, Smokeless - toxicity Trace elements |
| title | Chemistry and toxicology of smokeless tobacco |
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