Comparison of CD4 Cell Counts in Pregnant HIV-Seropositive and HIV-Seronegative Nigerian Women
To evaluate the CD4 cell count of human immunodeficiency virus (HIV)-positive pregnant ethnic Nigerian women and compare it with that of HIV-negative pregnant ethnic Nigerian women and to determine the relationship between CD4 cell count and the packed red blood cell volume (PCV) of HIV-seropositive...
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| Veröffentlicht in: | Laboratory medicine 2012-08, Vol.43 (5), p.168-171 |
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| creator | Ekwempu, Adaobi Ifeoma Ekwempu, Chinedu Chika Ikeh, Eugene Olabode, Atanda Agaba, Emmanuel |
| description | To evaluate the CD4 cell count of human immunodeficiency virus (HIV)-positive pregnant ethnic Nigerian women and compare it with that of HIV-negative pregnant ethnic Nigerian women and to determine the relationship between CD4 cell count and the packed red blood cell volume (PCV) of HIV-seropositive and HIV-seronegative pregnant women. The study population included 130 ethnic Nigerian women between the ages of 17 and 40 years who came to the Antenatal and Prevention of Mother-to-Child Transmission (PMTCT) units of Jos University Teaching Hospital, in Jos, Nigeria. Relevant information such as age, occupation, tribal affiliation, gestational age, and prescribed drugs currently taken were obtained using a structured questionnaire. A selective technique was used to enroll pregnant women who tested positive for HIV infection and negative for malaria parasitemia, syphilis, and hepatitis B virus, along with healthy pregnant women with no history of these diseases. CD4 cell counts were determined using a Cyflow machine and packed red blood cell volume (PCV) obtained using a microhematocrit centrifuge. The Student t-distribution t-test was used to analyze data. The highest prevalence of HIV infection was found in the group aged 26 to 30 years; the lowest prevalence was found in the group aged 36 to 40 years. The mean (SD) CD4 cell counts of HIVseropositive and seronegative women were 323.7 (170.7) and 578.3 (167.4), respectively (P < .001). Comparison of the CD4 cell count of HIV-positive and HIV-negative pregnant women with the PCV values from specimens from those women demonstrated a correlation coefficient r of 0.37 (P < .001) for the former group and an r of 0.37 (P < .82) for the latter. In HIV-seropositive and HIV-seronegative pregnant women with gestational age of less than 13 weeks, the mean (SD) CD4 cell counts were 610.X (170.3) (P < .001) and 302.0 (49.0) (P < .001) for the former and latter groups, respectively. The mean CD4 cell counts of the HIV-positive and HIV-negative pregnant women enrolled in our study with gestational age of 13 to 25 weeks and 26 to 38 weeks were 596 (146) (P < .001), 304 (170) (P < .001), 534 (189) (P < .001), and 254 (191) (P |
| doi_str_mv | 10.1309/LMM55QSHUTTX1OEA |
| format | Article |
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The study population included 130 ethnic Nigerian women between the ages of 17 and 40 years who came to the Antenatal and Prevention of Mother-to-Child Transmission (PMTCT) units of Jos University Teaching Hospital, in Jos, Nigeria. Relevant information such as age, occupation, tribal affiliation, gestational age, and prescribed drugs currently taken were obtained using a structured questionnaire. A selective technique was used to enroll pregnant women who tested positive for HIV infection and negative for malaria parasitemia, syphilis, and hepatitis B virus, along with healthy pregnant women with no history of these diseases. CD4 cell counts were determined using a Cyflow machine and packed red blood cell volume (PCV) obtained using a microhematocrit centrifuge. The Student t-distribution t-test was used to analyze data. The highest prevalence of HIV infection was found in the group aged 26 to 30 years; the lowest prevalence was found in the group aged 36 to 40 years. The mean (SD) CD4 cell counts of HIVseropositive and seronegative women were 323.7 (170.7) and 578.3 (167.4), respectively (P < .001). Comparison of the CD4 cell count of HIV-positive and HIV-negative pregnant women with the PCV values from specimens from those women demonstrated a correlation coefficient r of 0.37 (P < .001) for the former group and an r of 0.37 (P < .82) for the latter. In HIV-seropositive and HIV-seronegative pregnant women with gestational age of less than 13 weeks, the mean (SD) CD4 cell counts were 610.X (170.3) (P < .001) and 302.0 (49.0) (P < .001) for the former and latter groups, respectively. The mean CD4 cell counts of the HIV-positive and HIV-negative pregnant women enrolled in our study with gestational age of 13 to 25 weeks and 26 to 38 weeks were 596 (146) (P < .001), 304 (170) (P < .001), 534 (189) (P < .001), and 254 (191) (P <.003), respectively. This study suggests that pregnancy may partially deplete CD4 cells because a significant difference was observed in mean (SD) CD4 cell count in HIV-seropositive and HIV-seronegative pregnant women at various gestational ages. Chronological age did not affect the mean CD4 cell count if there was no accompanying disease condition. We also conclude that PCV in HIV-seropositive pregnant women was directly proportional to their CD4 cell counts.]]></description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1309/LMM55QSHUTTX1OEA</identifier><language>eng</language><publisher>Chicago: Oxford University Press</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; HIV ; Human immunodeficiency virus ; Pregnancy ; Womens health</subject><ispartof>Laboratory medicine, 2012-08, Vol.43 (5), p.168-171</ispartof><rights>Copyright American Society for Clinical Pathology Summer 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-ed81b543ad388072dedc3c3e29c9815c4c156c0aa2067cd2b9e62131795a4c073</citedby><cites>FETCH-LOGICAL-c360t-ed81b543ad388072dedc3c3e29c9815c4c156c0aa2067cd2b9e62131795a4c073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Ekwempu, Adaobi Ifeoma</creatorcontrib><creatorcontrib>Ekwempu, Chinedu Chika</creatorcontrib><creatorcontrib>Ikeh, Eugene</creatorcontrib><creatorcontrib>Olabode, Atanda</creatorcontrib><creatorcontrib>Agaba, Emmanuel</creatorcontrib><title>Comparison of CD4 Cell Counts in Pregnant HIV-Seropositive and HIV-Seronegative Nigerian Women</title><title>Laboratory medicine</title><description><![CDATA[To evaluate the CD4 cell count of human immunodeficiency virus (HIV)-positive pregnant ethnic Nigerian women and compare it with that of HIV-negative pregnant ethnic Nigerian women and to determine the relationship between CD4 cell count and the packed red blood cell volume (PCV) of HIV-seropositive and HIV-seronegative pregnant women. The study population included 130 ethnic Nigerian women between the ages of 17 and 40 years who came to the Antenatal and Prevention of Mother-to-Child Transmission (PMTCT) units of Jos University Teaching Hospital, in Jos, Nigeria. Relevant information such as age, occupation, tribal affiliation, gestational age, and prescribed drugs currently taken were obtained using a structured questionnaire. A selective technique was used to enroll pregnant women who tested positive for HIV infection and negative for malaria parasitemia, syphilis, and hepatitis B virus, along with healthy pregnant women with no history of these diseases. CD4 cell counts were determined using a Cyflow machine and packed red blood cell volume (PCV) obtained using a microhematocrit centrifuge. The Student t-distribution t-test was used to analyze data. The highest prevalence of HIV infection was found in the group aged 26 to 30 years; the lowest prevalence was found in the group aged 36 to 40 years. The mean (SD) CD4 cell counts of HIVseropositive and seronegative women were 323.7 (170.7) and 578.3 (167.4), respectively (P < .001). Comparison of the CD4 cell count of HIV-positive and HIV-negative pregnant women with the PCV values from specimens from those women demonstrated a correlation coefficient r of 0.37 (P < .001) for the former group and an r of 0.37 (P < .82) for the latter. In HIV-seropositive and HIV-seronegative pregnant women with gestational age of less than 13 weeks, the mean (SD) CD4 cell counts were 610.X (170.3) (P < .001) and 302.0 (49.0) (P < .001) for the former and latter groups, respectively. The mean CD4 cell counts of the HIV-positive and HIV-negative pregnant women enrolled in our study with gestational age of 13 to 25 weeks and 26 to 38 weeks were 596 (146) (P < .001), 304 (170) (P < .001), 534 (189) (P < .001), and 254 (191) (P <.003), respectively. This study suggests that pregnancy may partially deplete CD4 cells because a significant difference was observed in mean (SD) CD4 cell count in HIV-seropositive and HIV-seronegative pregnant women at various gestational ages. Chronological age did not affect the mean CD4 cell count if there was no accompanying disease condition. We also conclude that PCV in HIV-seropositive pregnant women was directly proportional to their CD4 cell counts.]]></description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Pregnancy</subject><subject>Womens health</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEFLAzEUhIMoWKt3jwHPqy95u5vNsazVFlqrtFVPLmk2LSltsiZbwX9vq-LB0zDDxwwMIZcMrhmCvBmNx1n2NB3MZ7NXNun3jkiHyRQTIRCOSQcARJIBF6fkLMb13qYy5x3yVvpto4KN3lG_pOVtSkuz2dDS71wbqXX0MZiVU66lg-FzMjXBNz7a1n4Yqlz9FzqzUt_hg12ZYJWjL35r3Dk5WapNNBe_2iXzu_6sHCSjyf2w7I0SjTm0iakLtshSVDUWBQhem1qjRsOllgXLdKpZlmtQikMudM0X0uScIRMyU6kGgV1y9dPbBP--M7Gt1n4X3H6yYsgRsIDiQMEPpYOPMZhl1QS7VeGzYlAdXqz-v4hf48dlgA</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Ekwempu, Adaobi Ifeoma</creator><creator>Ekwempu, Chinedu Chika</creator><creator>Ikeh, Eugene</creator><creator>Olabode, Atanda</creator><creator>Agaba, Emmanuel</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>201208</creationdate><title>Comparison of CD4 Cell Counts in Pregnant HIV-Seropositive and HIV-Seronegative Nigerian Women</title><author>Ekwempu, Adaobi Ifeoma ; Ekwempu, Chinedu Chika ; Ikeh, Eugene ; Olabode, Atanda ; Agaba, Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-ed81b543ad388072dedc3c3e29c9815c4c156c0aa2067cd2b9e62131795a4c073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Pregnancy</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekwempu, Adaobi Ifeoma</creatorcontrib><creatorcontrib>Ekwempu, Chinedu Chika</creatorcontrib><creatorcontrib>Ikeh, Eugene</creatorcontrib><creatorcontrib>Olabode, Atanda</creatorcontrib><creatorcontrib>Agaba, Emmanuel</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekwempu, Adaobi Ifeoma</au><au>Ekwempu, Chinedu Chika</au><au>Ikeh, Eugene</au><au>Olabode, Atanda</au><au>Agaba, Emmanuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of CD4 Cell Counts in Pregnant HIV-Seropositive and HIV-Seronegative Nigerian Women</atitle><jtitle>Laboratory medicine</jtitle><date>2012-08</date><risdate>2012</risdate><volume>43</volume><issue>5</issue><spage>168</spage><epage>171</epage><pages>168-171</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract><![CDATA[To evaluate the CD4 cell count of human immunodeficiency virus (HIV)-positive pregnant ethnic Nigerian women and compare it with that of HIV-negative pregnant ethnic Nigerian women and to determine the relationship between CD4 cell count and the packed red blood cell volume (PCV) of HIV-seropositive and HIV-seronegative pregnant women. The study population included 130 ethnic Nigerian women between the ages of 17 and 40 years who came to the Antenatal and Prevention of Mother-to-Child Transmission (PMTCT) units of Jos University Teaching Hospital, in Jos, Nigeria. Relevant information such as age, occupation, tribal affiliation, gestational age, and prescribed drugs currently taken were obtained using a structured questionnaire. A selective technique was used to enroll pregnant women who tested positive for HIV infection and negative for malaria parasitemia, syphilis, and hepatitis B virus, along with healthy pregnant women with no history of these diseases. CD4 cell counts were determined using a Cyflow machine and packed red blood cell volume (PCV) obtained using a microhematocrit centrifuge. The Student t-distribution t-test was used to analyze data. The highest prevalence of HIV infection was found in the group aged 26 to 30 years; the lowest prevalence was found in the group aged 36 to 40 years. The mean (SD) CD4 cell counts of HIVseropositive and seronegative women were 323.7 (170.7) and 578.3 (167.4), respectively (P < .001). Comparison of the CD4 cell count of HIV-positive and HIV-negative pregnant women with the PCV values from specimens from those women demonstrated a correlation coefficient r of 0.37 (P < .001) for the former group and an r of 0.37 (P < .82) for the latter. In HIV-seropositive and HIV-seronegative pregnant women with gestational age of less than 13 weeks, the mean (SD) CD4 cell counts were 610.X (170.3) (P < .001) and 302.0 (49.0) (P < .001) for the former and latter groups, respectively. The mean CD4 cell counts of the HIV-positive and HIV-negative pregnant women enrolled in our study with gestational age of 13 to 25 weeks and 26 to 38 weeks were 596 (146) (P < .001), 304 (170) (P < .001), 534 (189) (P < .001), and 254 (191) (P <.003), respectively. This study suggests that pregnancy may partially deplete CD4 cells because a significant difference was observed in mean (SD) CD4 cell count in HIV-seropositive and HIV-seronegative pregnant women at various gestational ages. Chronological age did not affect the mean CD4 cell count if there was no accompanying disease condition. We also conclude that PCV in HIV-seropositive pregnant women was directly proportional to their CD4 cell counts.]]></abstract><cop>Chicago</cop><pub>Oxford University Press</pub><doi>10.1309/LMM55QSHUTTX1OEA</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Laboratory medicine, 2012-08, Vol.43 (5), p.168-171 |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acquired immune deficiency syndrome AIDS HIV Human immunodeficiency virus Pregnancy Womens health |
| title | Comparison of CD4 Cell Counts in Pregnant HIV-Seropositive and HIV-Seronegative Nigerian Women |
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