Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

G protein-coupled receptor (GPR) 55 is sensitive to certain cannabinoids, it is expressed in the brain and, in cell cultures, it triggers mobilization of intracellular Ca ²⁺. However, the adaptive neurobiological significance of GPR55 remains unknown. Here, we use acute hippocampal slices and combin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-03, Vol.110 (13), p.5193-5198
Hauptverfasser:	Sylantyev, Sergiy, Jensen, Thomas P., Ross, Ruth A., Rusakov, Dmitri A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals antagonists Axons Biological Sciences Brain CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - metabolism CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - metabolism calcium Calcium - metabolism Calcium phosphates cannabidiol Cannabidiol - chemistry Cannabidiol - pharmacology Cannabis - chemistry Cannabis sativa cell culture Endocannabinoids G-protein coupled receptors Gene expression glutamic acid image analysis Inositol 1,4,5-Trisphosphate - metabolism inositols Ligands Marijuana Mice Mice, Knockout Microdissection Neurobiology Neurons Neurotransmitter Agents - metabolism Neurotransmitters phospholipids Presynaptic Terminals - metabolism probability Proteins Pyramidal cells Rats Receptors Receptors, Cannabinoid - genetics Receptors, Cannabinoid - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Synapses Synaptic Membranes - metabolism Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology synaptic vesicles
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