Effectiveness of pamidronate as treatment of symptomatic osteonecrosis occurring in children treated for acute lymphoblastic leukemia

Background Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in patients with sym...

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Veröffentlicht in:	Pediatric blood & cancer 2013-05, Vol.60 (5), p.741-747
Hauptverfasser:	Leblicq, Coralie, Laverdière, Caroline, Décarie, Jean-Claude, Delisle, Jean-François, Isler, Marc H., Moghrabi, Albert, Chabot, Gilles, Alos, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukemia Adolescent Arthralgia - drug therapy bisphosphonates Bone Density Conservation Agents - adverse effects Bone Density Conservation Agents - therapeutic use Child Child, Preschool Diphosphonates - adverse effects Diphosphonates - therapeutic use Female Hematology Humans Joints - pathology Knee Joint - pathology Male Motor Activity Oncology osteonecrosis Osteonecrosis - diagnosis Osteonecrosis - drug therapy Osteonecrosis - etiology Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Treatment Outcome Young Adult
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