Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years
Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI m...
Gespeichert in:
| Veröffentlicht in: | Digestion 2012-01, Vol.86 (4), p.323-328 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 328 |
|---|---|
| container_issue | 4 |
| container_start_page | 323 |
| container_title | Digestion |
| container_volume | 86 |
| creator | Watanabe, Akira Iwakiri, Ryuichi Yamaguchi, Daisuke Higuchi, Toru Tsuruoka, Nanae Miyahara, Koichi Akutagawa, Kayo Sakata, Yasuhisa Fujise, Takehiro Oda, Yasutomo Shimoda, Ryo Sakata, Hiroyuki Fujimoto, Kazuma |
| description | Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance. |
| doi_str_mv | 10.1159/000342393 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1316258881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2915552401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-57e03ab7a40e27b38ce826eeb6c3a623231ab71aa99e533637eee55468ff704f3</originalsourceid><addsrcrecordid>eNpd0cFP2zAUBnBrGhoFduA-TZZ2GYcM289xnCOqYCsCDSEQ2ilywgs1NHZmJxM98a_j0tLDTpbl3_v0rI-QQ85-cJ6Xx4wxkAJK-EAmXAqelVoVH8mEMS4yoQXskr0YH1fXUsInsiuACw1STsjLtY1P9Mw0gw-Rtj7Qa4w2DsY1SAdPr4IfvKNXY9fTmZvb2iZIL411A7o3dDPHYPrlZrZdjM_0NPp-bh7sYCO1jp6b3jiMSO98h476fxioYvQPmhAPyE5rFhE_b859cnt2ejP9lV38_jmbnlxkjYR8yPICGZi6MJKhKGrQDWqhEGvVgFEC0ofSKzemLDEHUFAgYp5Lpdu2YLKFffJ9ndsH_3fEOFSdjQ0uFmkzP8aKiwJUClI80W__0Uc_Bpe2qzhwJXKt9UodrVUTfIwB26oPtjNhWXFWrVqptq0k-3WTONYd3m_lew0JfFmDJxMeMGzBZv4Vz6WPjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1316258881</pqid></control><display><type>article</type><title>Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years</title><source>Karger Journals</source><source>MEDLINE</source><creator>Watanabe, Akira ; Iwakiri, Ryuichi ; Yamaguchi, Daisuke ; Higuchi, Toru ; Tsuruoka, Nanae ; Miyahara, Koichi ; Akutagawa, Kayo ; Sakata, Yasuhisa ; Fujise, Takehiro ; Oda, Yasutomo ; Shimoda, Ryo ; Sakata, Hiroyuki ; Fujimoto, Kazuma</creator><creatorcontrib>Watanabe, Akira ; Iwakiri, Ryuichi ; Yamaguchi, Daisuke ; Higuchi, Toru ; Tsuruoka, Nanae ; Miyahara, Koichi ; Akutagawa, Kayo ; Sakata, Yasuhisa ; Fujise, Takehiro ; Oda, Yasutomo ; Shimoda, Ryo ; Sakata, Hiroyuki ; Fujimoto, Kazuma</creatorcontrib><description>Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance.</description><identifier>ISSN: 0012-2823</identifier><identifier>EISSN: 1421-9867</identifier><identifier>DOI: 10.1159/000342393</identifier><identifier>PMID: 23128344</identifier><identifier>CODEN: DIGEBW</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aged ; Aged, 80 and over ; Analysis of Variance ; Confidence Intervals ; Drug Resistance ; Esophagitis, Peptic - complications ; Esophagitis, Peptic - drug therapy ; Female ; Helicobacter Infections - complications ; Helicobacter pylori ; Hernia, Hiatal - complications ; Humans ; Japan ; Kyphosis - complications ; Lumbar Vertebrae ; Maintenance Chemotherapy ; Middle Aged ; Odds Ratio ; Original Paper ; Proton Pump Inhibitors - therapeutic use ; Risk Factors ; Severity of Illness Index</subject><ispartof>Digestion, 2012-01, Vol.86 (4), p.323-328</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><rights>Copyright (c) 2013 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-57e03ab7a40e27b38ce826eeb6c3a623231ab71aa99e533637eee55468ff704f3</citedby><cites>FETCH-LOGICAL-c435t-57e03ab7a40e27b38ce826eeb6c3a623231ab71aa99e533637eee55468ff704f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23128344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Iwakiri, Ryuichi</creatorcontrib><creatorcontrib>Yamaguchi, Daisuke</creatorcontrib><creatorcontrib>Higuchi, Toru</creatorcontrib><creatorcontrib>Tsuruoka, Nanae</creatorcontrib><creatorcontrib>Miyahara, Koichi</creatorcontrib><creatorcontrib>Akutagawa, Kayo</creatorcontrib><creatorcontrib>Sakata, Yasuhisa</creatorcontrib><creatorcontrib>Fujise, Takehiro</creatorcontrib><creatorcontrib>Oda, Yasutomo</creatorcontrib><creatorcontrib>Shimoda, Ryo</creatorcontrib><creatorcontrib>Sakata, Hiroyuki</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><title>Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years</title><title>Digestion</title><addtitle>Digestion</addtitle><description>Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Confidence Intervals</subject><subject>Drug Resistance</subject><subject>Esophagitis, Peptic - complications</subject><subject>Esophagitis, Peptic - drug therapy</subject><subject>Female</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Hernia, Hiatal - complications</subject><subject>Humans</subject><subject>Japan</subject><subject>Kyphosis - complications</subject><subject>Lumbar Vertebrae</subject><subject>Maintenance Chemotherapy</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>0012-2823</issn><issn>1421-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0cFP2zAUBnBrGhoFduA-TZZ2GYcM289xnCOqYCsCDSEQ2ilywgs1NHZmJxM98a_j0tLDTpbl3_v0rI-QQ85-cJ6Xx4wxkAJK-EAmXAqelVoVH8mEMS4yoQXskr0YH1fXUsInsiuACw1STsjLtY1P9Mw0gw-Rtj7Qa4w2DsY1SAdPr4IfvKNXY9fTmZvb2iZIL411A7o3dDPHYPrlZrZdjM_0NPp-bh7sYCO1jp6b3jiMSO98h476fxioYvQPmhAPyE5rFhE_b859cnt2ejP9lV38_jmbnlxkjYR8yPICGZi6MJKhKGrQDWqhEGvVgFEC0ofSKzemLDEHUFAgYp5Lpdu2YLKFffJ9ndsH_3fEOFSdjQ0uFmkzP8aKiwJUClI80W__0Uc_Bpe2qzhwJXKt9UodrVUTfIwB26oPtjNhWXFWrVqptq0k-3WTONYd3m_lew0JfFmDJxMeMGzBZv4Vz6WPjw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Watanabe, Akira</creator><creator>Iwakiri, Ryuichi</creator><creator>Yamaguchi, Daisuke</creator><creator>Higuchi, Toru</creator><creator>Tsuruoka, Nanae</creator><creator>Miyahara, Koichi</creator><creator>Akutagawa, Kayo</creator><creator>Sakata, Yasuhisa</creator><creator>Fujise, Takehiro</creator><creator>Oda, Yasutomo</creator><creator>Shimoda, Ryo</creator><creator>Sakata, Hiroyuki</creator><creator>Fujimoto, Kazuma</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years</title><author>Watanabe, Akira ; Iwakiri, Ryuichi ; Yamaguchi, Daisuke ; Higuchi, Toru ; Tsuruoka, Nanae ; Miyahara, Koichi ; Akutagawa, Kayo ; Sakata, Yasuhisa ; Fujise, Takehiro ; Oda, Yasutomo ; Shimoda, Ryo ; Sakata, Hiroyuki ; Fujimoto, Kazuma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-57e03ab7a40e27b38ce826eeb6c3a623231ab71aa99e533637eee55468ff704f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Confidence Intervals</topic><topic>Drug Resistance</topic><topic>Esophagitis, Peptic - complications</topic><topic>Esophagitis, Peptic - drug therapy</topic><topic>Female</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Hernia, Hiatal - complications</topic><topic>Humans</topic><topic>Japan</topic><topic>Kyphosis - complications</topic><topic>Lumbar Vertebrae</topic><topic>Maintenance Chemotherapy</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Iwakiri, Ryuichi</creatorcontrib><creatorcontrib>Yamaguchi, Daisuke</creatorcontrib><creatorcontrib>Higuchi, Toru</creatorcontrib><creatorcontrib>Tsuruoka, Nanae</creatorcontrib><creatorcontrib>Miyahara, Koichi</creatorcontrib><creatorcontrib>Akutagawa, Kayo</creatorcontrib><creatorcontrib>Sakata, Yasuhisa</creatorcontrib><creatorcontrib>Fujise, Takehiro</creatorcontrib><creatorcontrib>Oda, Yasutomo</creatorcontrib><creatorcontrib>Shimoda, Ryo</creatorcontrib><creatorcontrib>Sakata, Hiroyuki</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Digestion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Akira</au><au>Iwakiri, Ryuichi</au><au>Yamaguchi, Daisuke</au><au>Higuchi, Toru</au><au>Tsuruoka, Nanae</au><au>Miyahara, Koichi</au><au>Akutagawa, Kayo</au><au>Sakata, Yasuhisa</au><au>Fujise, Takehiro</au><au>Oda, Yasutomo</au><au>Shimoda, Ryo</au><au>Sakata, Hiroyuki</au><au>Fujimoto, Kazuma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years</atitle><jtitle>Digestion</jtitle><addtitle>Digestion</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>86</volume><issue>4</issue><spage>323</spage><epage>328</epage><pages>323-328</pages><issn>0012-2823</issn><eissn>1421-9867</eissn><coden>DIGEBW</coden><abstract>Aim: The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. Methods: The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. Results: The characteristics of all 462 patients were: age: 76.4 ± 7.6 years, height: 147.2 ± 6.1 cm, weight: 49.9 ± 8.4 kg and body mass index: 24.0 ± 3.5. The reflux esophagitis grades were A in 69.5%, B in 15.8%, C in 9.1% and D in 5.6%. Helicobacter pylori was positive in 60.6%. Regarding PPI maintenance therapy for clinical symptoms evaluated by the attending physicians, 66.7% were ‘good control’, 26.8% were ‘reasonable control’ and 6.5% were ‘bad control: resistant’. PPI maintenance therapy was less effective in patients with more severe reflux esophagitis of grades C and D (OR: 0.027; 95% CI: 0.010–0.077) and negative H. pylori infection status (OR: 4.470; 95% CI: 1.631–12.247). Lumbar kyphosis and hiatus hernia were risk factors for severity grading of reflux esophagitis. Conclusions: PPI maintenance therapy evaluated by attending physicians indicated that reflux esophagitis severity and negative H. pylori status were risk factors for treatment resistance.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>23128344</pmid><doi>10.1159/000342393</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-2823 |
| ispartof | Digestion, 2012-01, Vol.86 (4), p.323-328 |
| issn | 0012-2823 1421-9867 |
| language | eng |
| recordid | cdi_proquest_journals_1316258881 |
| source | Karger Journals; MEDLINE |
| subjects | Aged Aged, 80 and over Analysis of Variance Confidence Intervals Drug Resistance Esophagitis, Peptic - complications Esophagitis, Peptic - drug therapy Female Helicobacter Infections - complications Helicobacter pylori Hernia, Hiatal - complications Humans Japan Kyphosis - complications Lumbar Vertebrae Maintenance Chemotherapy Middle Aged Odds Ratio Original Paper Proton Pump Inhibitors - therapeutic use Risk Factors Severity of Illness Index |
| title | Risk Factors for Resistance to Proton Pump Inhibitor Maintenance Therapy for Reflux Esophagitis in Japanese Women over 60 Years |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A33%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20Factors%20for%20Resistance%20to%20Proton%20Pump%20Inhibitor%20Maintenance%20Therapy%20for%20Reflux%20Esophagitis%20in%20Japanese%20Women%20over%2060%20Years&rft.jtitle=Digestion&rft.au=Watanabe,%20Akira&rft.date=2012-01-01&rft.volume=86&rft.issue=4&rft.spage=323&rft.epage=328&rft.pages=323-328&rft.issn=0012-2823&rft.eissn=1421-9867&rft.coden=DIGEBW&rft_id=info:doi/10.1159/000342393&rft_dat=%3Cproquest_cross%3E2915552401%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1316258881&rft_id=info:pmid/23128344&rfr_iscdi=true |