A Systematic Approach to Mapping Recessive Disease Genes in Individuals from Outbred Populations: e1000353

The identification of recessive disease-causing genes by homozygosity mapping is often restricted by lack of suitable consanguineous families. To overcome these limitations, we apply homozygosity mapping to single affected individuals from outbred populations. In 72 individuals of 54 kindred ascerta...

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Veröffentlicht in:	PLoS genetics 2009-01, Vol.5 (1)
Hauptverfasser:	Hildebrandt, Friedhelm, Heeringa, Saskia F, Rüschendorf, Franz, Attanasio, Massimo, Nürnberg, Gudrun, Becker, Christian, Seelow, Dominik, Huebner, Norbert, Chernin, Gil, Vlangos, Christopher N, Zhou, Weibin, Hoskins, Bethan E, Wolf, Matthias TF, Hinkes, Bernward G, Chaib, Hassan, Ashraf, Shazia, Schoeb, Dominik S, Ovunc, Bugsu, Allen, Susan J, Vega-Warner, Virginia, Wise, Eric, Harville, Heather M, Lyons, Robert H, Washburn, Joseph, MacDonald, James, Nürnberg, Peter, Otto, Edgar A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrays Families & family life Genes Genetics Genomes Haplotypes Mutation Parents & parenting Pediatrics
Online-Zugang:	Volltext
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