Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5: e1002245

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5+/m) mice tha...

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Veröffentlicht in:	PLoS genetics 2011-08, Vol.7 (8)
Hauptverfasser:	Bell, Daphne W, Sikdar, Nilabja, Lee, Kyoo-young, Price, Jessica C, Chatterjee, Raghunath, Park, Hee-Dong, Fox, Jennifer, Ishiai, Masamichi, Rudd, Meghan L, Pollock, Lana M, Fogoros, Sarah K, Mohamed, Hassan, Hanigan, Christin L, Zhang, Suiyuan, Cruz, Pedro, Renaud, Gabriel, Hansen, Nancy F, Cherukuri, Praveen F, Borate, Bhavesh, McManus, Kirk J, Stoepel, Jan, Sipahimalani, Payal, Godwin, Andrew K, Sgroi, Dennis C, Merino, Maria J, Elliot, Gene, Elkahloun, Abdel, Vinson, Charles, Takata, Minoru, Mullikin, James C, Wolfsberg, Tyra G, Hieter, Philip, Lim, Dae-Sik, Myung, Kyungjae, Program, NISC ComparativeSequencing
Format:	Artikel
Sprache:	eng
Schlagworte:	Endometrial cancer Genetics Medical research Mutation Proteins Tumors
Online-Zugang:	Volltext
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