Modeling Co-Expression across Species for Complex Traits: Insights to the Difference of Human and Mouse Embryonic Stem Cells: e1000707

Complex interactions between genes or proteins contribute substantially to phenotypic evolution. We present a probabilistic model and a maximum likelihood approach for cross-species clustering analysis and for identification of conserved as well as species-specific co-expression modules. This model...

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Veröffentlicht in:	PLoS computational biology 2010-03, Vol.6 (3)
Hauptverfasser:	Cai, Jun, Xie, Dan, Fan, Zhewen, Chipperfield, Hiram, Marden, John, Wong, Wing H, Zhong, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Comparative analysis Evolution Evolution & development Gene expression Genetics Proteins Signal transduction Stem cells
Online-Zugang:	Volltext
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