Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significa...

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Veröffentlicht in:	The American journal of psychiatry 1992-11, Vol.149 (11), p.1592-1594
Hauptverfasser:	RENSHAW, P. F, GUIMARAES, A. R, FAVA, M, ROSENBAUM, J. F, PEARLMAN, J. D, FLOOD, J. G, PUOPOLO, P. R, CLANCY, K, GONZALEZ, R. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain - metabolism Confidence Intervals Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - metabolism Female Fluorine Fluoxetine - analogs & derivatives Fluoxetine - blood Fluoxetine - metabolism Fluoxetine - therapeutic use Humans Magnetic Resonance Spectroscopy Male Medical sciences Neuropharmacology Obsessive-Compulsive Disorder - blood Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - metabolism Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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