CSF gamma-aminobutyric acid in alcoholics and control subjects
Alcohol has widespread effects on the gamma-aminobutyric acid (GABA) system in the brain. This system in the brain is also postulated to have a role in anxiety, and alcoholics have been reported to have more anxiety disorders. Therefore, the authors undertook a study to compare CSF levels of GABA in...
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| Veröffentlicht in: | The American journal of psychiatry 1990-10, Vol.147 (10), p.1294-1296 |
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| container_issue | 10 |
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| container_title | The American journal of psychiatry |
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| creator | ROY, A DEJONG, J FERRARO, T ADINOFF, B RAVITZ, B LINNOILA, M |
| description | Alcohol has widespread effects on the gamma-aminobutyric acid (GABA)
system in the brain. This system in the brain is also postulated to have a
role in anxiety, and alcoholics have been reported to have more anxiety
disorders. Therefore, the authors undertook a study to compare CSF levels
of GABA in abstinent alcoholic patients and normal control subjects. There
was no significant difference between groups in CSF levels of GABA. Also,
there was no significant difference in GABA level between alcoholic
patients with histories of withdrawal seizures and those without such a
history. |
| doi_str_mv | 10.1176/ajp.147.10.1294 |
| format | Article |
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system in the brain. This system in the brain is also postulated to have a
role in anxiety, and alcoholics have been reported to have more anxiety
disorders. Therefore, the authors undertook a study to compare CSF levels
of GABA in abstinent alcoholic patients and normal control subjects. There
was no significant difference between groups in CSF levels of GABA. Also,
there was no significant difference in GABA level between alcoholic
patients with histories of withdrawal seizures and those without such a
history.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.147.10.1294</identifier><identifier>PMID: 2399995</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Age Factors ; Alcohol Drinking ; Alcoholism - cerebrospinal fluid ; Biological and medical sciences ; Chromatography, Ion Exchange ; Ethanol - adverse effects ; Female ; gamma-Aminobutyric Acid - cerebrospinal fluid ; Humans ; Male ; Medical sciences ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Seizures - cerebrospinal fluid ; Sex Factors ; Sexual Abstinence ; Substance Withdrawal Syndrome - cerebrospinal fluid ; Substance Withdrawal Syndrome - etiology ; Techniques and methods</subject><ispartof>The American journal of psychiatry, 1990-10, Vol.147 (10), p.1294-1296</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a387t-3abfb44d24f379c931419e1a2b7ae03de8d13dd1c3f79c39f3e80725854da69e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.147.10.1294$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.147.10.1294$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2846,21608,27846,27901,27902,77533,77534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19252423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2399995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROY, A</creatorcontrib><creatorcontrib>DEJONG, J</creatorcontrib><creatorcontrib>FERRARO, T</creatorcontrib><creatorcontrib>ADINOFF, B</creatorcontrib><creatorcontrib>RAVITZ, B</creatorcontrib><creatorcontrib>LINNOILA, M</creatorcontrib><title>CSF gamma-aminobutyric acid in alcoholics and control subjects</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Alcohol has widespread effects on the gamma-aminobutyric acid (GABA)
system in the brain. This system in the brain is also postulated to have a
role in anxiety, and alcoholics have been reported to have more anxiety
disorders. Therefore, the authors undertook a study to compare CSF levels
of GABA in abstinent alcoholic patients and normal control subjects. There
was no significant difference between groups in CSF levels of GABA. Also,
there was no significant difference in GABA level between alcoholic
patients with histories of withdrawal seizures and those without such a
history.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Alcohol Drinking</subject><subject>Alcoholism - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Ion Exchange</subject><subject>Ethanol - adverse effects</subject><subject>Female</subject><subject>gamma-Aminobutyric Acid - cerebrospinal fluid</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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system in the brain. This system in the brain is also postulated to have a
role in anxiety, and alcoholics have been reported to have more anxiety
disorders. Therefore, the authors undertook a study to compare CSF levels
of GABA in abstinent alcoholic patients and normal control subjects. There
was no significant difference between groups in CSF levels of GABA. Also,
there was no significant difference in GABA level between alcoholic
patients with histories of withdrawal seizures and those without such a
history.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>2399995</pmid><doi>10.1176/ajp.147.10.1294</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1990-10, Vol.147 (10), p.1294-1296 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_journals_1310602762 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Age Factors Alcohol Drinking Alcoholism - cerebrospinal fluid Biological and medical sciences Chromatography, Ion Exchange Ethanol - adverse effects Female gamma-Aminobutyric Acid - cerebrospinal fluid Humans Male Medical sciences Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Seizures - cerebrospinal fluid Sex Factors Sexual Abstinence Substance Withdrawal Syndrome - cerebrospinal fluid Substance Withdrawal Syndrome - etiology Techniques and methods |
| title | CSF gamma-aminobutyric acid in alcoholics and control subjects |
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