Reversal of Delirium Induced by Tricyclic Antidepressant Drugs with Physostigmine
The authors found that 2 mg. of physostigmine given intramuscularly was effective in reversing acute brain syndromes in two patients who had ingested toxic doses of drugs with anticholinergic properties (amitriptyline alone and an amitriptyline-perphenazine combination). Physostigmine also controlle...
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| Veröffentlicht in: | The American journal of psychiatry 1974-11, Vol.131 (11), p.1275-1277 |
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| container_end_page | 1277 |
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| container_title | The American journal of psychiatry |
| container_volume | 131 |
| creator | HEISER, JON F WILBERT, DONALD E |
| description | The authors found that 2 mg. of physostigmine given intramuscularly was effective in reversing acute brain syndromes in two patients who had ingested toxic doses of drugs with anticholinergic properties (amitriptyline alone and an amitriptyline-perphenazine combination). Physostigmine also controlled one patient's tachycardia and tachypnea. Physostigmine may not control toxic effects of anticholinergic drugs when these effects are not mediated through cholinergic blockade. |
| doi_str_mv | 10.1176/ajp.131.11.1275 |
| format | Article |
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Physostigmine also controlled one patient's tachycardia and tachypnea. 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| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1974-11, Vol.131 (11), p.1275-1277 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_journals_1310599997 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Amitriptyline - administration & dosage Amitriptyline - adverse effects Amitriptyline - antagonists & inhibitors Amitriptyline - poisoning Antidotes - therapeutic use Delirium - chemically induced Delirium - drug therapy Drug Combinations Female Humans Male Middle Aged Perphenazine - administration & dosage Perphenazine - poisoning Physostigmine - therapeutic use |
| title | Reversal of Delirium Induced by Tricyclic Antidepressant Drugs with Physostigmine |
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