ORAL CONTRACEPTIVE USE AND THE RISK OF MYOCARDIAL INFARCTION
The relation of oral contraceptive use to the risk of myocardial infarction was assessed in a hospital-based case-control study of women aged 25–64 years conducted from 1985 to 1988 in New England; 910 women with first myocardial infarctions were compared with 1,760 control women. Oral contraceptive...
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| Veröffentlicht in: | American journal of epidemiology 1990-06, Vol.131 (6), p.1009-1016 |
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| container_title | American journal of epidemiology |
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| creator | ROSENBERG, LYNN PALMER, JULIE R. LESKO, SAMUEL M. SHAPIRO, SAMUEL |
| description | The relation of oral contraceptive use to the risk of myocardial infarction was assessed in a hospital-based case-control study of women aged 25–64 years conducted from 1985 to 1988 in New England; 910 women with first myocardial infarctions were compared with 1,760 control women. Oral contraceptive use, after discontinuation, was not associated with an increased risk of myocardial infarction, whether use had ceased in the distant past or more recently. The overall relative risk estimate for women who had used oral contraceptives in the past for at least 5 years compared with nonusers was 1.1 (95% confidence interval 0.8–1.5) after allowance for confounding factors. Past use was not associated with risk in any age group, in subgroups of women with predisposing factors, or in women at low risk because of the absence of predisposing factors. The results suggest that long-term oral contraceptive use, after discontinuation, does not influence the risk of myocardial infarction. There were few current users and the results for current use were inconclusive: for premenopausal women who had used oral contraceptives in the previous month relative to those who had not, the age-adjusted relative risk estimate was 1.1 (95% confidence interval 0.4–3.1). |
| doi_str_mv | 10.1093/oxfordjournals.aje.a115592 |
| format | Article |
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Oral contraceptive use, after discontinuation, was not associated with an increased risk of myocardial infarction, whether use had ceased in the distant past or more recently. The overall relative risk estimate for women who had used oral contraceptives in the past for at least 5 years compared with nonusers was 1.1 (95% confidence interval 0.8–1.5) after allowance for confounding factors. Past use was not associated with risk in any age group, in subgroups of women with predisposing factors, or in women at low risk because of the absence of predisposing factors. The results suggest that long-term oral contraceptive use, after discontinuation, does not influence the risk of myocardial infarction. There were few current users and the results for current use were inconclusive: for premenopausal women who had used oral contraceptives in the previous month relative to those who had not, the age-adjusted relative risk estimate was 1.1 (95% confidence interval 0.4–3.1).</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a115592</identifier><identifier>PMID: 2343853</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Confounding Factors (Epidemiology) ; contraceptives ; Contraceptives, Oral - adverse effects ; Female ; Heart ; Humans ; Medical sciences ; Middle Aged ; myocardial infarction ; Myocardial Infarction - chemically induced ; oral ; Regression Analysis ; Risk ; Smoking - adverse effects ; Time Factors</subject><ispartof>American journal of epidemiology, 1990-06, Vol.131 (6), p.1009-1016</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-2ea64ace18a2b8487dcc1a55dc90d757b387c22204874e74b6b16c1bf45341b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27846,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4650098$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2343853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSENBERG, LYNN</creatorcontrib><creatorcontrib>PALMER, JULIE R.</creatorcontrib><creatorcontrib>LESKO, SAMUEL M.</creatorcontrib><creatorcontrib>SHAPIRO, SAMUEL</creatorcontrib><title>ORAL CONTRACEPTIVE USE AND THE RISK OF MYOCARDIAL INFARCTION</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>The relation of oral contraceptive use to the risk of myocardial infarction was assessed in a hospital-based case-control study of women aged 25–64 years conducted from 1985 to 1988 in New England; 910 women with first myocardial infarctions were compared with 1,760 control women. Oral contraceptive use, after discontinuation, was not associated with an increased risk of myocardial infarction, whether use had ceased in the distant past or more recently. The overall relative risk estimate for women who had used oral contraceptives in the past for at least 5 years compared with nonusers was 1.1 (95% confidence interval 0.8–1.5) after allowance for confounding factors. Past use was not associated with risk in any age group, in subgroups of women with predisposing factors, or in women at low risk because of the absence of predisposing factors. The results suggest that long-term oral contraceptive use, after discontinuation, does not influence the risk of myocardial infarction. There were few current users and the results for current use were inconclusive: for premenopausal women who had used oral contraceptives in the previous month relative to those who had not, the age-adjusted relative risk estimate was 1.1 (95% confidence interval 0.4–3.1).</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Confounding Factors (Epidemiology)</subject><subject>contraceptives</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - chemically induced</subject><subject>oral</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Smoking - adverse effects</subject><subject>Time Factors</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpVkF1LwzAUhoMoOj9-glDU2858txVvSu1cdbZSq-huQpqmsDmtJhvovzeyOvAm5-J9zsk5DwAnCA4RjMh599V2ppl3K_MuF3Yo53ooEWIswltggGjAfY4Z3wYDCCH2I8zxHti3dg4hQhGDu2AXE0pCRgbgsijjiZcUeVXGSXpfZU-p9_iQenF-5VXj1Cuzh1uvGHl3L0USl1eZg7N8FJdJlRX5Idhp3QL6qK8HoBqlVTL2J8V1lsQTX1EYLX2sJadSaRRKXIc0DBqlkGSsURFsAhbUJAwUxhi6iOqA1rxGXKG6pYxQVJMDcLoe-2G6z5W2S_F3ukAEcs6gex11saaU6aw1uhUfZvYmzbdAUPxqE_-1CadN9Npc83H_xap-082mtffk8rM-l1bJRWvku5rZDUbdDjAKHeavsZld6q9NLM2r4AEJmBg_T0V-w6bPt3wqIvIDycSEOg</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>ROSENBERG, LYNN</creator><creator>PALMER, JULIE R.</creator><creator>LESKO, SAMUEL M.</creator><creator>SHAPIRO, SAMUEL</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope></search><sort><creationdate>19900601</creationdate><title>ORAL CONTRACEPTIVE USE AND THE RISK OF MYOCARDIAL INFARCTION</title><author>ROSENBERG, LYNN ; PALMER, JULIE R. ; LESKO, SAMUEL M. ; SHAPIRO, SAMUEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-2ea64ace18a2b8487dcc1a55dc90d757b387c22204874e74b6b16c1bf45341b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Confounding Factors (Epidemiology)</topic><topic>contraceptives</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - chemically induced</topic><topic>oral</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>Smoking - adverse effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSENBERG, LYNN</creatorcontrib><creatorcontrib>PALMER, JULIE R.</creatorcontrib><creatorcontrib>LESKO, SAMUEL M.</creatorcontrib><creatorcontrib>SHAPIRO, SAMUEL</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 24</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSENBERG, LYNN</au><au>PALMER, JULIE R.</au><au>LESKO, SAMUEL M.</au><au>SHAPIRO, SAMUEL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ORAL CONTRACEPTIVE USE AND THE RISK OF MYOCARDIAL INFARCTION</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>131</volume><issue>6</issue><spage>1009</spage><epage>1016</epage><pages>1009-1016</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>The relation of oral contraceptive use to the risk of myocardial infarction was assessed in a hospital-based case-control study of women aged 25–64 years conducted from 1985 to 1988 in New England; 910 women with first myocardial infarctions were compared with 1,760 control women. Oral contraceptive use, after discontinuation, was not associated with an increased risk of myocardial infarction, whether use had ceased in the distant past or more recently. The overall relative risk estimate for women who had used oral contraceptives in the past for at least 5 years compared with nonusers was 1.1 (95% confidence interval 0.8–1.5) after allowance for confounding factors. Past use was not associated with risk in any age group, in subgroups of women with predisposing factors, or in women at low risk because of the absence of predisposing factors. The results suggest that long-term oral contraceptive use, after discontinuation, does not influence the risk of myocardial infarction. There were few current users and the results for current use were inconclusive: for premenopausal women who had used oral contraceptives in the previous month relative to those who had not, the age-adjusted relative risk estimate was 1.1 (95% confidence interval 0.4–3.1).</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>2343853</pmid><doi>10.1093/oxfordjournals.aje.a115592</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of epidemiology, 1990-06, Vol.131 (6), p.1009-1016 |
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| subjects | Adult Biological and medical sciences Cardiology. Vascular system Case-Control Studies Confounding Factors (Epidemiology) contraceptives Contraceptives, Oral - adverse effects Female Heart Humans Medical sciences Middle Aged myocardial infarction Myocardial Infarction - chemically induced oral Regression Analysis Risk Smoking - adverse effects Time Factors |
| title | ORAL CONTRACEPTIVE USE AND THE RISK OF MYOCARDIAL INFARCTION |
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