OVERCROWDING AND INTENSIVE EXPOSURE AS DETERMINANTS OF MEASLES MORTALITY
Data from a 1979 measles epidemic in an urban district of Gulnea-Blssau indicate that state of nutrition is not a major determinant of outcome of infection. However, overcrowding increases the risk of early infection and the severity of disease. In instances in which several children have measles si...
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| Veröffentlicht in: | American journal of epidemiology 1984-07, Vol.120 (1), p.49-63 |
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| creator | AABY, PETER BUKH, JETTE LISSE, IDA MARIA SMITS, ARJON J. |
| description | Data from a 1979 measles epidemic in an urban district of Gulnea-Blssau indicate that state of nutrition is not a major determinant of outcome of infection. However, overcrowding increases the risk of early infection and the severity of disease. In instances in which several children have measles simultaneously, the case fatality rate is significantly higher than for isolated cases. This tendency is apparently a result of intensity of exposure; within the same house, secondary cases have a much higher age-specific case fatality rate than index cases. It is suggested that the association between intensive exposure and severity of infection may be due to increased rates of intercurrent infection and/or a greater dose of infection. Since it is not only the malnourished children who die of measles, vaccination may have a greater importance for survival patterns than has previously been assumed. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a113874 |
| format | Article |
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However, overcrowding increases the risk of early infection and the severity of disease. In instances in which several children have measles simultaneously, the case fatality rate is significantly higher than for isolated cases. This tendency is apparently a result of intensity of exposure; within the same house, secondary cases have a much higher age-specific case fatality rate than index cases. It is suggested that the association between intensive exposure and severity of infection may be due to increased rates of intercurrent infection and/or a greater dose of infection. 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However, overcrowding increases the risk of early infection and the severity of disease. In instances in which several children have measles simultaneously, the case fatality rate is significantly higher than for isolated cases. This tendency is apparently a result of intensity of exposure; within the same house, secondary cases have a much higher age-specific case fatality rate than index cases. It is suggested that the association between intensive exposure and severity of infection may be due to increased rates of intercurrent infection and/or a greater dose of infection. 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| ispartof | American journal of epidemiology, 1984-07, Vol.120 (1), p.49-63 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Age Factors Biological and medical sciences Child Child, Preschool Crowding Education Environmental Exposure Ethnic Groups Family Characteristics Female Guinea-Bissau housing Human viral diseases Humans Infant Infant, Newborn Infectious diseases Male malnutrition measles Measles - mortality measles vaccine Medical sciences Nutrition Disorders - complications Risk Socioeconomic Factors Space-Time Clustering Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | OVERCROWDING AND INTENSIVE EXPOSURE AS DETERMINANTS OF MEASLES MORTALITY |
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