Toxicity of water extracted rapeseed meal in the rat
The toxic effect of different concentrations of “detoxified” rapeseed meal (DRSM) obtained by 2 h lixiviation was studied. This preparation contained 0.02 % oxazolidinethiones (VTO) and no detectable isothiocyanates (ITC). It was fed for 4 weeks to weanling rats in amounts that provided from 0 to 10...
Gespeichert in:
| Veröffentlicht in: | Journal of the science of food and agriculture 1977-09, Vol.28 (9), p.855-862 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 862 |
|---|---|
| container_issue | 9 |
| container_start_page | 855 |
| container_title | Journal of the science of food and agriculture |
| container_volume | 28 |
| creator | Ballester, Digna King, Judith Vera, Patricia Brunser, Oscar Yáñez, Enrique Monckeberg, Fernando |
| description | The toxic effect of different concentrations of “detoxified” rapeseed meal (DRSM) obtained by 2 h lixiviation was studied. This preparation contained 0.02 % oxazolidinethiones (VTO) and no detectable isothiocyanates (ITC). It was fed for 4 weeks to weanling rats in amounts that provided from 0 to 100% of total dietary protein. The control diet provided 20% protein from casein. Another control group was fed crude rapeseed meal (RSM) to the same protein level. Growth rates and protein efficiency ratio (PER) were similar in rats fed DRSM and casein diets. The substitution of casein by increasing levels of DRSM did not modify PER. The weight of the liver, thyroid, heart, spleen, adrenals and kidneys was normal. In animals fed DRSM no histological changes were detected in the liver. The thyroid exhibited changes similar to, but of lesser severity than in animals fed crude RSM. It is suggested that other toxic compound(s) may be present in rapeseed meal that are not extractable by lixiviation. The need of further investigations of the effect of this “detoxified” product including functional studies before its extensive inclusion in animal or human diets is emphasised. |
| doi_str_mv | 10.1002/jsfa.2740280914 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1303106104</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1303106104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4094-e28f9ae8ad55388a1e2edbe2a578231d1e2ea29569670e4a7e9a3198630e4fc73</originalsourceid><addsrcrecordid>eNqFUE1PAjEQbYxfiJ69eNjE88K03d1u4wmJ4Fc0UVRuTdmdjYvAYlsC_HtLlmA8eZqv997MPELOKbQoAGuPbaFbTETAUpA02iMNClKEABT2ScMjWBjTiB2TE2vHACBlkhyRQwkRB94g0aBalVnp1kFVBEvt0AS4ckZnDvPA6Dla9MkU9SQoZ4H7RN90p-Sg0BOLZ9vYJG-9m0H3Nnx87t91O49hFoGMQmRpITWmOo9jnqaaIsN8hEzHImWc5ptaMxknMhGAkRYoNacyTbivikzwJrmsdeem-l6gdWpcLczMr1TUX08hof6NJmnXqMxU1hos1NyUU23WioLaeKQ2HqlfjzzjYqu7GE0x3-FrU_z4qh4vywmu_1NT96-9zh_xsGaX1uFqx9bmSyWCi1h9PPXV8GX40O3H7-qa_wCQoYD_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1303106104</pqid></control><display><type>article</type><title>Toxicity of water extracted rapeseed meal in the rat</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Periodicals Index Online</source><creator>Ballester, Digna ; King, Judith ; Vera, Patricia ; Brunser, Oscar ; Yáñez, Enrique ; Monckeberg, Fernando</creator><creatorcontrib>Ballester, Digna ; King, Judith ; Vera, Patricia ; Brunser, Oscar ; Yáñez, Enrique ; Monckeberg, Fernando</creatorcontrib><description>The toxic effect of different concentrations of “detoxified” rapeseed meal (DRSM) obtained by 2 h lixiviation was studied. This preparation contained 0.02 % oxazolidinethiones (VTO) and no detectable isothiocyanates (ITC). It was fed for 4 weeks to weanling rats in amounts that provided from 0 to 100% of total dietary protein. The control diet provided 20% protein from casein. Another control group was fed crude rapeseed meal (RSM) to the same protein level. Growth rates and protein efficiency ratio (PER) were similar in rats fed DRSM and casein diets. The substitution of casein by increasing levels of DRSM did not modify PER. The weight of the liver, thyroid, heart, spleen, adrenals and kidneys was normal. In animals fed DRSM no histological changes were detected in the liver. The thyroid exhibited changes similar to, but of lesser severity than in animals fed crude RSM. It is suggested that other toxic compound(s) may be present in rapeseed meal that are not extractable by lixiviation. The need of further investigations of the effect of this “detoxified” product including functional studies before its extensive inclusion in animal or human diets is emphasised.</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.2740280914</identifier><identifier>PMID: 904303</identifier><language>eng</language><publisher>London: John Wiley & Sons, Ltd</publisher><subject>Animals ; Body Weight ; Brassica - analysis ; Dietary Proteins - standards ; Female ; Liver - pathology ; Male ; Organ Size ; Plant Poisoning - pathology ; Plant Proteins - toxicity ; Rats ; Thyroid Gland - pathology</subject><ispartof>Journal of the science of food and agriculture, 1977-09, Vol.28 (9), p.855-862</ispartof><rights>Copyright © 1977 John Wiley & Sons, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4094-e28f9ae8ad55388a1e2edbe2a578231d1e2ea29569670e4a7e9a3198630e4fc73</citedby><cites>FETCH-LOGICAL-c4094-e28f9ae8ad55388a1e2edbe2a578231d1e2ea29569670e4a7e9a3198630e4fc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.2740280914$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.2740280914$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27867,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/904303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ballester, Digna</creatorcontrib><creatorcontrib>King, Judith</creatorcontrib><creatorcontrib>Vera, Patricia</creatorcontrib><creatorcontrib>Brunser, Oscar</creatorcontrib><creatorcontrib>Yáñez, Enrique</creatorcontrib><creatorcontrib>Monckeberg, Fernando</creatorcontrib><title>Toxicity of water extracted rapeseed meal in the rat</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>The toxic effect of different concentrations of “detoxified” rapeseed meal (DRSM) obtained by 2 h lixiviation was studied. This preparation contained 0.02 % oxazolidinethiones (VTO) and no detectable isothiocyanates (ITC). It was fed for 4 weeks to weanling rats in amounts that provided from 0 to 100% of total dietary protein. The control diet provided 20% protein from casein. Another control group was fed crude rapeseed meal (RSM) to the same protein level. Growth rates and protein efficiency ratio (PER) were similar in rats fed DRSM and casein diets. The substitution of casein by increasing levels of DRSM did not modify PER. The weight of the liver, thyroid, heart, spleen, adrenals and kidneys was normal. In animals fed DRSM no histological changes were detected in the liver. The thyroid exhibited changes similar to, but of lesser severity than in animals fed crude RSM. It is suggested that other toxic compound(s) may be present in rapeseed meal that are not extractable by lixiviation. The need of further investigations of the effect of this “detoxified” product including functional studies before its extensive inclusion in animal or human diets is emphasised.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Brassica - analysis</subject><subject>Dietary Proteins - standards</subject><subject>Female</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Organ Size</subject><subject>Plant Poisoning - pathology</subject><subject>Plant Proteins - toxicity</subject><subject>Rats</subject><subject>Thyroid Gland - pathology</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqFUE1PAjEQbYxfiJ69eNjE88K03d1u4wmJ4Fc0UVRuTdmdjYvAYlsC_HtLlmA8eZqv997MPELOKbQoAGuPbaFbTETAUpA02iMNClKEABT2ScMjWBjTiB2TE2vHACBlkhyRQwkRB94g0aBalVnp1kFVBEvt0AS4ckZnDvPA6Dla9MkU9SQoZ4H7RN90p-Sg0BOLZ9vYJG-9m0H3Nnx87t91O49hFoGMQmRpITWmOo9jnqaaIsN8hEzHImWc5ptaMxknMhGAkRYoNacyTbivikzwJrmsdeem-l6gdWpcLczMr1TUX08hof6NJmnXqMxU1hos1NyUU23WioLaeKQ2HqlfjzzjYqu7GE0x3-FrU_z4qh4vywmu_1NT96-9zh_xsGaX1uFqx9bmSyWCi1h9PPXV8GX40O3H7-qa_wCQoYD_</recordid><startdate>197709</startdate><enddate>197709</enddate><creator>Ballester, Digna</creator><creator>King, Judith</creator><creator>Vera, Patricia</creator><creator>Brunser, Oscar</creator><creator>Yáñez, Enrique</creator><creator>Monckeberg, Fernando</creator><general>John Wiley & Sons, Ltd</general><general>Published for the Society of Chemical Industry by Elsevier Applied Science</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HJHVS</scope><scope>IZSXY</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope></search><sort><creationdate>197709</creationdate><title>Toxicity of water extracted rapeseed meal in the rat</title><author>Ballester, Digna ; King, Judith ; Vera, Patricia ; Brunser, Oscar ; Yáñez, Enrique ; Monckeberg, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4094-e28f9ae8ad55388a1e2edbe2a578231d1e2ea29569670e4a7e9a3198630e4fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Brassica - analysis</topic><topic>Dietary Proteins - standards</topic><topic>Female</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Organ Size</topic><topic>Plant Poisoning - pathology</topic><topic>Plant Proteins - toxicity</topic><topic>Rats</topic><topic>Thyroid Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ballester, Digna</creatorcontrib><creatorcontrib>King, Judith</creatorcontrib><creatorcontrib>Vera, Patricia</creatorcontrib><creatorcontrib>Brunser, Oscar</creatorcontrib><creatorcontrib>Yáñez, Enrique</creatorcontrib><creatorcontrib>Monckeberg, Fernando</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 19</collection><collection>Periodicals Index Online Segment 30</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ballester, Digna</au><au>King, Judith</au><au>Vera, Patricia</au><au>Brunser, Oscar</au><au>Yáñez, Enrique</au><au>Monckeberg, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity of water extracted rapeseed meal in the rat</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>1977-09</date><risdate>1977</risdate><volume>28</volume><issue>9</issue><spage>855</spage><epage>862</epage><pages>855-862</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>The toxic effect of different concentrations of “detoxified” rapeseed meal (DRSM) obtained by 2 h lixiviation was studied. This preparation contained 0.02 % oxazolidinethiones (VTO) and no detectable isothiocyanates (ITC). It was fed for 4 weeks to weanling rats in amounts that provided from 0 to 100% of total dietary protein. The control diet provided 20% protein from casein. Another control group was fed crude rapeseed meal (RSM) to the same protein level. Growth rates and protein efficiency ratio (PER) were similar in rats fed DRSM and casein diets. The substitution of casein by increasing levels of DRSM did not modify PER. The weight of the liver, thyroid, heart, spleen, adrenals and kidneys was normal. In animals fed DRSM no histological changes were detected in the liver. The thyroid exhibited changes similar to, but of lesser severity than in animals fed crude RSM. It is suggested that other toxic compound(s) may be present in rapeseed meal that are not extractable by lixiviation. The need of further investigations of the effect of this “detoxified” product including functional studies before its extensive inclusion in animal or human diets is emphasised.</abstract><cop>London</cop><pub>John Wiley & Sons, Ltd</pub><pmid>904303</pmid><doi>10.1002/jsfa.2740280914</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5142 |
| ispartof | Journal of the science of food and agriculture, 1977-09, Vol.28 (9), p.855-862 |
| issn | 0022-5142 1097-0010 |
| language | eng |
| recordid | cdi_proquest_journals_1303106104 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Periodicals Index Online |
| subjects | Animals Body Weight Brassica - analysis Dietary Proteins - standards Female Liver - pathology Male Organ Size Plant Poisoning - pathology Plant Proteins - toxicity Rats Thyroid Gland - pathology |
| title | Toxicity of water extracted rapeseed meal in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T23%3A26%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toxicity%20of%20water%20extracted%20rapeseed%20meal%20in%20the%20rat&rft.jtitle=Journal%20of%20the%20science%20of%20food%20and%20agriculture&rft.au=Ballester,%20Digna&rft.date=1977-09&rft.volume=28&rft.issue=9&rft.spage=855&rft.epage=862&rft.pages=855-862&rft.issn=0022-5142&rft.eissn=1097-0010&rft_id=info:doi/10.1002/jsfa.2740280914&rft_dat=%3Cproquest_cross%3E1303106104%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1303106104&rft_id=info:pmid/904303&rfr_iscdi=true |