Photosensitivity from chlorophyll-derived pigments
The photosensitisation of young albino rats fed diets containing specially prepared lucerne leaf protein concentrates (LPC) or purified pigments has been investigated. Signs of intense photosensitivity including death occurred after a few hours of illumination in animals fed a diet containing 20% LP...
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| Veröffentlicht in: | Journal of the science of food and agriculture 1975-03, Vol.26 (3), p.277-284 |
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| container_end_page | 284 |
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| container_title | Journal of the science of food and agriculture |
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| creator | Tapper, Brian A. Lohrey, Evelyn Hove, Edwin L. Allison, Russell M. |
| description | The photosensitisation of young albino rats fed diets containing specially prepared lucerne leaf protein concentrates (LPC) or purified pigments has been investigated. Signs of intense photosensitivity including death occurred after a few hours of illumination in animals fed a diet containing 20% LPC prepared by holding lucerne juice at 70 °C for 55 min. However a sample prepared by briefly heating juice to 90 °C was not active. Mixed chlorophyllides and purified pheophorbide a were strongly photosensitising whereas pheophorbide b was much less active and pheophytin a was inactive. Where strong photosensitisation occurred pigments derived from chlorophyll could be extracted from blood plasma and livers. Examination of stomach and intestine contents showed that dietary chlorophyllides and chlorophylls were converted to pheophorbides and pheophytins in the gut. The photosensitising potential of a diet can be related principally to the combined content of pheophorbide a and chlorophyllide a. |
| doi_str_mv | 10.1002/jsfa.2740260307 |
| format | Article |
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Signs of intense photosensitivity including death occurred after a few hours of illumination in animals fed a diet containing 20% LPC prepared by holding lucerne juice at 70 °C for 55 min. However a sample prepared by briefly heating juice to 90 °C was not active. Mixed chlorophyllides and purified pheophorbide a were strongly photosensitising whereas pheophorbide b was much less active and pheophytin a was inactive. Where strong photosensitisation occurred pigments derived from chlorophyll could be extracted from blood plasma and livers. Examination of stomach and intestine contents showed that dietary chlorophyllides and chlorophylls were converted to pheophorbides and pheophytins in the gut. The photosensitising potential of a diet can be related principally to the combined content of pheophorbide a and chlorophyllide a.</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.2740260307</identifier><identifier>PMID: 1134066</identifier><language>eng</language><publisher>London: John Wiley & Sons, Ltd</publisher><subject>Animals ; Chlorophyll - adverse effects ; Chlorophyll - analysis ; Chlorophyllides - adverse effects ; Chlorophyllides - analysis ; Dietary Proteins - adverse effects ; Light ; Medicago sativa - analysis ; Pheophytins - adverse effects ; Pheophytins - analysis ; Photosensitivity Disorders - etiology ; Photosensitivity Disorders - mortality ; Pigments, Biological - metabolism ; Plant Proteins - adverse effects ; Rats</subject><ispartof>Journal of the science of food and agriculture, 1975-03, Vol.26 (3), p.277-284</ispartof><rights>Copyright © 1975 John Wiley & Sons, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4107-98be7c522d718223ff2c51556103ff2e0e1c738602504fcdee8b17564354a5583</citedby><cites>FETCH-LOGICAL-c4107-98be7c522d718223ff2c51556103ff2e0e1c738602504fcdee8b17564354a5583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.2740260307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.2740260307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27869,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1134066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tapper, Brian A.</creatorcontrib><creatorcontrib>Lohrey, Evelyn</creatorcontrib><creatorcontrib>Hove, Edwin L.</creatorcontrib><creatorcontrib>Allison, Russell M.</creatorcontrib><title>Photosensitivity from chlorophyll-derived pigments</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>The photosensitisation of young albino rats fed diets containing specially prepared lucerne leaf protein concentrates (LPC) or purified pigments has been investigated. Signs of intense photosensitivity including death occurred after a few hours of illumination in animals fed a diet containing 20% LPC prepared by holding lucerne juice at 70 °C for 55 min. However a sample prepared by briefly heating juice to 90 °C was not active. Mixed chlorophyllides and purified pheophorbide a were strongly photosensitising whereas pheophorbide b was much less active and pheophytin a was inactive. Where strong photosensitisation occurred pigments derived from chlorophyll could be extracted from blood plasma and livers. Examination of stomach and intestine contents showed that dietary chlorophyllides and chlorophylls were converted to pheophorbides and pheophytins in the gut. The photosensitising potential of a diet can be related principally to the combined content of pheophorbide a and chlorophyllide a.</description><subject>Animals</subject><subject>Chlorophyll - adverse effects</subject><subject>Chlorophyll - analysis</subject><subject>Chlorophyllides - adverse effects</subject><subject>Chlorophyllides - analysis</subject><subject>Dietary Proteins - adverse effects</subject><subject>Light</subject><subject>Medicago sativa - analysis</subject><subject>Pheophytins - adverse effects</subject><subject>Pheophytins - analysis</subject><subject>Photosensitivity Disorders - etiology</subject><subject>Photosensitivity Disorders - mortality</subject><subject>Pigments, Biological - metabolism</subject><subject>Plant Proteins - adverse effects</subject><subject>Rats</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqFkE1PwkAQhjdGg4iePZmQeC7M7HZ323hCIvhBlCjG46a0Wym2tO4WtP_ekhKJJ08zyTzvM8lLyDlCDwFof2njoEelC1QAA3lA2gi-dAAQDkm7JqjD0aXH5MTaJQD4vhAt0kJkLgjRJnS6yMvc6pVNymSTlFU3NnnWDRdpbvJiUaWpE2mTbHTULZL3TK9Ke0qO4iC1-mw3O-R1dDMb3jqTp_HdcDBxQhdBOr431zLklEYSPUpZHNOQI-cCYbtr0BhK5gmgHNw4jLT25ii5cBl3A8491iGXjbcw-eda21It87VZ1S8VMmAIHAFrqt9QocmtNTpWhUmywFQKQW0rUtuK1L6iOnGx867nmY72fNNJfb9q7l9Jqqv_dOr-ZTT4Y3eadGJL_f2bDsyHEpJJrt4exwofptPHZ36tZuwH8ouA0w</recordid><startdate>197503</startdate><enddate>197503</enddate><creator>Tapper, Brian A.</creator><creator>Lohrey, Evelyn</creator><creator>Hove, Edwin L.</creator><creator>Allison, Russell M.</creator><general>John Wiley & Sons, Ltd</general><general>Published for the Society of Chemical Industry by Elsevier Applied Science</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HJHVS</scope><scope>IZSXY</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope></search><sort><creationdate>197503</creationdate><title>Photosensitivity from chlorophyll-derived pigments</title><author>Tapper, Brian A. ; Lohrey, Evelyn ; Hove, Edwin L. ; Allison, Russell M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4107-98be7c522d718223ff2c51556103ff2e0e1c738602504fcdee8b17564354a5583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Chlorophyll - adverse effects</topic><topic>Chlorophyll - analysis</topic><topic>Chlorophyllides - adverse effects</topic><topic>Chlorophyllides - analysis</topic><topic>Dietary Proteins - adverse effects</topic><topic>Light</topic><topic>Medicago sativa - analysis</topic><topic>Pheophytins - adverse effects</topic><topic>Pheophytins - analysis</topic><topic>Photosensitivity Disorders - etiology</topic><topic>Photosensitivity Disorders - mortality</topic><topic>Pigments, Biological - metabolism</topic><topic>Plant Proteins - adverse effects</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tapper, Brian A.</creatorcontrib><creatorcontrib>Lohrey, Evelyn</creatorcontrib><creatorcontrib>Hove, Edwin L.</creatorcontrib><creatorcontrib>Allison, Russell M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 19</collection><collection>Periodicals Index Online Segment 30</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tapper, Brian A.</au><au>Lohrey, Evelyn</au><au>Hove, Edwin L.</au><au>Allison, Russell M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photosensitivity from chlorophyll-derived pigments</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. 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Examination of stomach and intestine contents showed that dietary chlorophyllides and chlorophylls were converted to pheophorbides and pheophytins in the gut. The photosensitising potential of a diet can be related principally to the combined content of pheophorbide a and chlorophyllide a.</abstract><cop>London</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1134066</pmid><doi>10.1002/jsfa.2740260307</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 1975-03, Vol.26 (3), p.277-284 |
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| source | MEDLINE; Periodicals Index Online; Wiley Online Library All Journals |
| subjects | Animals Chlorophyll - adverse effects Chlorophyll - analysis Chlorophyllides - adverse effects Chlorophyllides - analysis Dietary Proteins - adverse effects Light Medicago sativa - analysis Pheophytins - adverse effects Pheophytins - analysis Photosensitivity Disorders - etiology Photosensitivity Disorders - mortality Pigments, Biological - metabolism Plant Proteins - adverse effects Rats |
| title | Photosensitivity from chlorophyll-derived pigments |
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